A5042202591- Renal cell carcinoma treatment
- Cancer Genomics and Diagnostics
- Renal and related cancers
- Cutaneous Melanoma Detection and Management
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Melanoma and MAPK Pathways
- Immune Cell Function and Interaction
- Cervical Cancer and HPV Research
- Immunotherapy and Immune Responses
- Breast Cancer Treatment Studies
- Microbial Inactivation Methods
- Lymphatic System and Diseases
- Viral-associated cancers and disorders
- Parvovirus B19 Infection Studies
- Cell death mechanisms and regulation
- Glutathione Transferases and Polymorphisms
- Cancer Research and Treatments
- Angiogenesis and VEGF in Cancer
- Cancer Cells and Metastasis
- Systemic Lupus Erythematosus Research
- Bladder and Urothelial Cancer Treatments
- Leprosy Research and Treatment
- T-cell and B-cell Immunology
- MicroRNA in disease regulation
Universitas Gadjah Mada
2012-2024
Rumah Sakit Umum Pusat Dr. Sardjito
2024
University Medical Center Groningen
2017-2022
University of Groningen
2017-2022
The Keap1/Nrf2 pathway is a master regulator of the cellular redox state through induction several antioxidant defence genes implicated in chemotherapeutic drugs resistance tumor cells. An increasing body evidence supports key role for kidney diseases and renal cell carcinoma (RCC), but data concerning molecular basis clinical effect its deregulation remain incomplete.Here we present profiling KEAP1 NFE2L2 five different Renal Cell Carcinoma histotypes by analysing 89 tumor/normal paired...
Introduction: Prostate cancer in Indonesia is the <TEX>$3^{rd}$</TEX> ranking among males and <TEX>$5^{th}$</TEX> rank for their mortality. Prognostic markers that can identify aggressive prostate early stages help select appropriate therapy to finally reduce mortality are therefore urgently needed. It has been suggested stem cells gland have a role initiation, progression, metastasis of cancer, although controversy continues exist. Maintenance normal cell or reserve populations several...
While intratumour genetic heterogeneity of primary clear cell renal carcinoma (ccRCC) is well characterized, the genomic profiles metastatic ccRCCs are seldom studied. We profiled genomes and transcriptomes a tumour matched metastases to better understand evolutionary processes that lead metastasis. In one ccRCC patient, four regions tumour, region thrombus in inferior vena cava, lung (including taken after pegylated (PEG)-interferon therapy) were analysed separately. Each sample was for...
Background: Lymphangiogenesis, assessed as lymphovascular density (LVD), is the initial step of generalized tumor invasion (LVI). It also involves VEGF-C most important protein family. Lymphangiogenesis among breast cancer cases correlations with several clinicopathological factors are to determine prognosis and treatment strategies, but results have been controversial require clarification. Aim: To define between expression, LVD LVI parameters from Indonesian patients. Materials Methods:...
Basal cell carcinoma (BCC) is the most common skin malignancy worldwide. Current evidence suggests tumour-infiltrating lymphocytes (TILs) may influence clinical outcomes of patients with BCC. The present study aimed to profile infiltrative characteristics stromal TILs and regulatory T cells (Treg cells) in tumour centre (TC), periphery (TP), normal adjacent tissue (NAT) A total 111 samples from 43 cutaneous BCC cases were examined for TIL (CD3+) Treg (FOXP3+/CD3+) expression using...
Only a limited number of studies have explored the possible associations between tumour grade and mutated genes in clear cell renal carcinoma (ccRCC), we set out to investigate this further using multiple sampling next generation sequencing (NGS) approach series ccRCCs. Multiple regions were sampled from formalin-fixated paraffin-embedded ccRCC blocks seven patients. In 27 samples six patients, performed targeted NGS custom 42-gene panel based on most frequently reported public databases....
Langerhans Cell Histiocytosis (LCH) is a rare disease characterized by the clonal proliferation of cells, which are immunoreactive to S-100 and CD-1a/ CD207 (Langerin). Cutaneous involvement most common presentation LCH in children. It suggested that patients with single-system limited skin have better prognosis than those systemic involvement. Three histologic reactions cutaneous been reported associated clinical types LCH. These histological include: proliferative, granulomatous,...
Abstract: Although historically known as a genetic disorder, epidermodysplasia verruciformis (EV) might be acquired in patients with noninherited defective cell-mediated immunity. This article reports case of EV patient systemic lupus erythematosus and history 3 years immunosuppressive methylprednisolone treatment. The microscopic features the skin biopsy showed morphologic changes keratinocytes characteristic human papilloma virus (HPV) infections immunoreactivity to p16. HPV genotyping...
Abstract In this study, we investigate the influence of seven genes ( VHL, PBRM1, SETD2, BAP1, KDM5C, MTOR and TP53 ) most frequently mutated in clear cell renal cancer (ccRCC) on cancer-specific survival (CSS) prospective Netherlands Cohort Study diet cancer. DNA isolated from routinely archived formalin-fixed paraffin-embedded tumour blocks 252 incident ccRCC cases was available for targeted next generation sequencing. Based sequencing quality completeness information clinical...
Abstract The Keap1/Nrf2 pathway is a master regulator of the cellular redox state through induction several antioxidant defense genes implicated in chemotherapeutic drugs resistance tumor cells. An increasing body evidence supports key role for kidney diseases and renal cell carcinoma, but data concerning molecular basis clinical effect its deregulation remain incomplete. Here we performed comprehensive genetic epigenetic analysis KEAP1 gene 37 tumor/normal paired tissues clear Renal...
Nasopharyngeal carcinoma (NPC) is a common type of cancer in Southeast Asia. This usually spreads locally and to nearby lymph nodes. One unique feature NPC its many immune cells called tumor-infiltrating lymphocytes (TILs). Recent studies have suggested that TILs types can indicate better prognosis. However, the role still matter debate. Further research necessary determine whether be used as prognostic factor NPC's outcome.
Targeted therapies have shown promise in improving survival rates for lung adenocarcinoma, a common and deadly malignancy. EGFR-targeting tyrosine kinase inhibitors (TKIs) are particularly effective among these cases with EGFR mutations. Detecting mutations before TKI treatment is essential. Various radiological features been linked to However, the relationship between tumor location mutation types Indonesian adenocarcinoma patients remains unexplored. This study aimed identify frequency of...
Melanomas are rare yet the most aggressive skin cancer among Asians. Clinical presentation, risk factors, and underlying molecular mechanisms strikingly different from cutaneous melanoma in Caucasians.
Lupus panniculitis is included in the chronic cutaneous lupus erythematosus group. An 18-year-old female patient came with complaint of lumps on her face. When she was 16 years old, started to complain about right lower arm. Lumps were observed left cheek and chin during ongoing treatment. Histopathology results showed lymphocyte infiltration between lobular adipocyte fibrotic fat necrosis subcutis. lesions this found both face arms, which are not considered common predilection sites...
Melanoma is a lethal skin malignancy with high risk of metastasis, which prompts need for research on treatment targets and prognostic factors. Recent studies show that the presence neuroblastoma RAS viral oncogene homolog (NRAS) mutation can influence cell growth in melanomas. The NRAS mutation, stimulates mitogen-activated protein kinase (MAPK) signaling pathway, associated lower survival rate. However, evidence from Indonesia population still very rare. Further understanding role...