A5101821292- Cancer Treatment and Pharmacology
- Advanced Breast Cancer Therapies
- HER2/EGFR in Cancer Research
- Breast Cancer Treatment Studies
- Sarcoma Diagnosis and Treatment
- Cardiac tumors and thrombi
- Colorectal Cancer Treatments and Studies
- Prostate Cancer Treatment and Research
- BRCA gene mutations in cancer
- Cancer Genomics and Diagnostics
- Peptidase Inhibition and Analysis
- Cell Adhesion Molecules Research
- PI3K/AKT/mTOR signaling in cancer
- Protein Degradation and Inhibitors
- Chemotherapy-induced cardiotoxicity and mitigation
- Estrogen and related hormone effects
- Multiple Myeloma Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Hip disorders and treatments
- Chronic Lymphocytic Leukemia Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Treatments and Mutations
- Cancer Diagnosis and Treatment
- Angiogenesis and VEGF in Cancer
- Renal cell carcinoma treatment
Azienda Ospedaliera Universitaria Pisana
2015-2024
Ospedale Santa Chiara
2012-2024
University of Pisa
2010-2023
Casa Sollievo della Sofferenza
2017-2020
Fondazione Lanza
2015-2019
Clinique de Genolier
2016
Central European Cooperative Oncology Group
2016
Azienda Usl Toscana Centro
2016
Tumour Institute of Tuscany
2013
IRCCS Istituto Auxologico Italiano
2012
Purpose Regulation of epidermal growth factor receptor (EGFR) signaling pathways may play a relevant role in determining the activity cetuximab therapy patients with metastatic colorectal cancer (MCRC). We investigated possible associations between genetic variants and clinical outcomes MCRC treated cetuximab-irinotecan salvage therapy. Patients Methods who underwent after disease progression during or first-line bolus/infusional fluorouracil, leucovorin, oxaliplatin chemotherapy second-line...
•Baseline PN was associated with longer on-study and a lower resolution rate in both study arms.•Prior platinum more grade 3-4 thrombocytopenia T-DM1, but not ≥3 hemorrhage.•IDFS benefit T-DM1 versus trastuzumab similar irrespective of neoadjuvant therapy containing anthracyclines.•T-DM1 an increased overall risk CNS recurrence.•The IDFS maintained high-risk tumors defined by operable status, nodal involvement, HR status. BackgroundIn the KATHERINE (NCT01772472), patients residual invasive...
The repair of chondral lesions associated with femoroacetabular impingement requires specific treatment in addition to that the impingement. In this single-centre retrospective analysis a consecutive series patients we compared microfracture (MFx) technique enhanced autologous matrix-induced chondrogenesis (AMIC). Acetabular grade III and IV measuring between 2 cm 8 147 were treated by MFx 77 AMIC 70. outcome was assessed using modified Harris hip score at six months one, two, three, four...
Bone metastasis represents an increasing clinical problem in advanced renal cell carcinoma (RCC) as disease-related survival improves. There are few data on the natural history of bone disease RCC.Data clinicopathology, survival, skeletal-related events (SREs), and bone-directed therapies for 398 deceased RCC patients (286 male, 112 female) with evidence were statistically analyzed.Median time to was 25 months without at diagnosis. Median diagnosis by MSKCC risk 24 good, 5 intermediate, 0...
Aim of this study was to investigate for the presence existing prognostic factors in patients with bone metastases (BMs) from RCC since represents an unfavorable site metastasis renal cell carcinoma (mRCC). Data BMs were retrospectively collected. Age, sex, ECOG-Performance Status (PS), MSKCC group, tumor histology, concomitant other sites, time nephrectomy (TTBM, classified into three groups: <1 year, between 1 and 5 years >5 years) skeletal-related event (SRE) included Cox analysis their...
Proton-pump-inhibitors (PPIs) are frequently prescribed for the management of anticancer drug-related gastrointestinal symptoms. Palbociclib is a weak base with pH-dependent solubility and potential drug-drug interaction at absorption level may affect clinical pharmacokinetics. The current study was aimed investigating effect co-administration PPIs palbociclib on progression-free survival (PFS) in metastatic breast cancer (mBC) patients.Patients affected by estrogen receptor-positive, human...
Abstract Purpose: The aims of the present study were to evaluate clinical activity and pharmacodynamic profile novel schedule a single i.v. standard dose cyclophosphamide (CTX) immediately followed by an oral metronomic CTX regimen with celecoxib (CXB) dexamethasone (DEX) in advanced hormone-refractory prostate cancer patients. Experimental Design: Twenty-eight patients (68% docetaxel-resistant) received 500 mg/m2 bolus on day 1 and, from 2, 50 mg/day p.o. plus 200 mg/twice CXB DEX until...
Microfracture is the standard of care for treatment small cartilage defects in hip. Autologous matrix-induced chondrogenesis (AMIC) a novel, 1-step approach that combines microfracture with type I/III collagen matrix (Chondro-Gide; Geistlich Pharma AG, Wolhusen, Switzerland) to cover microfractured defect area. The AMIC procedure has been successfully established treating knee and talus, we report, first time, its application More importantly, at our center, have developed fully arthroscopic...
To evaluate UFT and cyclophosphamide (CTX) based metronomic chemotherapy plus celecoxib (CXB) for the treatment of patients with heavily pre-treated advanced gastrointestinal malignancies.Thirty-eight received 500 mg/mq(2) CTX i.v bolus on day 1 and, from 2, 50 mg/day p.o. 100 mg/twice a 200 CXB Tegafur, 5-FU, 5-FUH(2), GHB uracil pharmacokinetics were assessed. Plasma vascular endothelial growth factor (VEGF), soluble VE-cadherin (sVE-C) thrombospondin-1 (TSP-1) levels detected by ELISA...
Hormone receptor expression is a known positive prognostic and predictive factor in breast cancer; however, limited evidence exists on its impact prognosis of young patients harboring pathogenic variant (PV) the BRCA1 and/or BRCA2 genes.
The anaphylatoxin C5a has been implicated in the pathogenesis of bacterial meningitis as a potent mediator inflammation subarachnoid space. We investigated expression receptor for (C5aR) brains mice with experimental Listeria monocytogenes (LM) meningoencephalitis. In course disease, infiltrating cells meninges and ventricles were found to express C5aR mRNA protein. brain parenchyma, very low constitutive was seen on pyramidal neurons Purkinje cells. However, LM-infected mice, dramatic...
This study aimed to define the maximum-tolerated dose (MTD) of fixed rate (FDR) gemcitabine (2′-2′-difluorodeoxycitidine) infusion with circulating haemopoietic progenitor support and evaluate activity treatment. Secondary end points were pharmacokinetic difluorodeoxyuridina (dFdU) measured at first course andexpression profile cytidine deaminase (CdA) on mononuclear cells. Patients advanced pancreatic carcinoma received escalating 10 mg m−2 min−1 every 2 weeks support. First level was 3000...
Chloroplast group IIA introns derive from bacterial ribozymes. Their splicing likely requires Maturase K (MatK), which has been largely inaccessible to functional analyses being itself a chloroplast intron-encoded protein. Here we show that MatK physically interacts with conserved, essential plastid-localized homolog of starch-branching enzymes (BEs), dubbed MATURASE INTERACTING PROTEIN1 (MKIP1). We demonstrate MKIP1 proteins have lost BE activity and acquired an insertion enabling direct...
BACKGROUND Docetaxel plus prednisone is currently the standard first‐line treatment in metastatic castration‐resistant prostate cancer (mCRPC). The aim of this study was to assess clinical activity and pharmacodynamic/pharmacogenetic profile docetaxel combination with metronomic cyclophosphamide mCRPC patients. METHODS Forty‐one chemotherapy‐naive patients received (60 mg/m 2 intravenously every 3 weeks up 12 cycles) and, from day 2, 10 mg/day, celecoxib 400 50 continuously. Plasma VEGF bFGF...