Smart surfaces presenting both antifouling molecules with a charged functional group at their distal end, and that are terminated by RGD peptides for cell adhesion, were fabricated characterized (see picture). By applying potentials of +300 or -300 mV, the could be dynamically switched to make peptide accessible inaccessible cells.

In this letter, we report results of a hydrosilylation carried out on bifunctional molecules by using two different approaches, namely through thermal treatment and photochemical UV irradiation. Previously, our group also demonstrated that in mixed alkyne/alcohol solution, surface coupling is biased towards the formation Si–O–C linkages instead Si–C linkages, thus indirectly supporting kinetic model hydrogen abstraction from Si–H (Khung, Y. L. et al. Chem. – Eur. J. 2014, 20, 15151–15158)....

The application of layer-by-layer (LbL) approach on nanoparticle surface coating improves the colon-specific drug delivery insoluble drugs. Here, we aimed to formulate a self-assembled cysteamine-based disulphide cross-linked sodium alginate with LbL self-assembly improve paclitaxel (PCX) colonic cancer cells. Cysteamine was conjugated backbone oxidized SA form core nanospheres. P3DL selected for PCX loading and fabricated poly(allylamine hydrochloride) (PAH) poly(4-styrenesulfonic...

Abstract BACKGROUND Drumstick ( Moringa oleifera) leaves have been used as a folk herbal medicine across many cultures since ancient times. This is most probably due to presence of phytochemicals possessing antioxidant properties, which could retard oxidative stress, and their degenerative effect. The current study deals with nanoencapsulation oleifera (MO) leaf ethanolic extract within fish sourced gelatine matrix using electrospinning technique. RESULTS total phenolic flavonoid content,...

Abstract In a stringent and near oxygen‐free environment, SiH surfaces were introduced to trifluoroalkyne, an alcohol‐derivatized alkyne, as well equal mixture of both alkynes at temperature 130 °C. Contact angle measurements, high‐resolution X‐ray photoelectron spectroscopy (XPS), angle‐resolved XPS performed examine the system. found have strong preference towards formation SiOC rather than SiC bonds when alcohol alkyne reactivities compared.

Using two different hydrosilylation methods, low temperature thermal and UV initiation, silicon (111) hydrogenated surfaces were functionalized in presence of an OH-terminated alkyne, a CF3-terminated alkyne mixed equimolar ratio the alkynes. XPS studies revealed that absence premeditated surface radical through hydrosilylation, grafting proceeded to form Si-O-C linkage via nucleophilic reaction OH group alkyne. This led small increase roughness as well hydrophobicity this effect was...

Myocardial infarction remains the number one killer disease worldwide. Cellular therapy using cardiac c-kit cells (CCs) are capable of regenerating injured heart. Previous studies showed mesenchymal stem cell-derived (MSC) extracellular matrices can provide structural support and regulating cell functions differentiation. This study aimed to evaluate effects human MSC-derived for CC growth Human Wharton's Jelly-derived MSCs were cultured in ascorbic acid supplemented medium 14 days prior...

Intelligente Oberflächen wurden hergestellt und charakterisiert, die zwei Arten von Molekülen tragen: anwuchsverhindernde Moleküle mit endständigen geladenen funktionellen Gruppen sowie Moleküle, RGD-Peptiden für Zelladhäsion terminiert sind (siehe Bild). Durch Anlegen Spannungen +300 oder −300 mV konnten zwischen zelladhäsiv zellabweisend dynamisch geschaltet werden.

Two types of memristor sensor were fabricated using two different TiO2 deposition methods sputtering and sol-gel spin coating. The surface morphology the sensors behaviour analysed by scanning electron microscopy with energy dispersive x-ray system I-V characterisation respectively. applied liquid hydroxyl group to check capability this in sensing concentration ion inside liquid. For that purpose, d-glucose four concentrations 10 mM, 20 30 mM 40 chosen. liquids dispensed onto act as...

Cell migration contributes to cancer metastasis and involves cell adhesion the extracellular matrix (ECM), force generation through cell's cytoskeletal, finally detachment. Both adhesive cues from ECM soluble neighbouring cells tissue trigger intracellular signalling pathways that are essential for migration. While machinery of many is relatively well understood, how hierarchies different conflicting signals established a new area cellular research. We examine recent advances in...

Topography and surface chemistry have a profound effect on the way in which cells interact with an implant, turn impacts clinical use performance. In this paper we examine electrochemical polishing approach H2SO4/methanol that can be applied to widely used orthopaedic/dentistry implant material, Ti6Al4V, produce structured surfaces. The roughness, as characterized by Ra, was found dependent time of electropolishing but not voltage parameters here. chemistry, however, potential. It chemical...

Simple structure of fluidic based memristor sensor with high R <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">off</inf> /R xmlns:xlink="http://www.w3.org/1999/xlink">on</inf> ratio 117,118 is reported. This used as a new sensing mechanism to detect different D-Glucose concentrations, this was first time implemented in bio-sensing applications. fabricated nano thickness well using sol gel spin coating technique titanium dioxide the material. The...

Discovery and use of biocompatible polymers offers great promise in the pharmaceutical field, particularly drug delivery systems. Disulphide bonds, which commonly occur peptides proteins have been used as drug-glutathione conjugates, are reductively cleaved colon. The intrinsic stability a disulphide relative to thiol groups is determined by redox potential environment. objective this study was synthesise trimesic acid-based cross-linked polymer that could potentially be for targeted monomer...

This paper reports a new design of TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> thin film memristor sensor with nano-well implementation. Three nano-wells diameters 0.5, 1 and 2 mm fabricated using lift-off techniques. 30 nm deposited RF sputtering process. The behavior the was being observed through ROFF/RON ratios to represent hysteresis loop area sensor. ratio in two conditions; free liquid liquid. For liquid, exposed air while...

The study outlined a standardized double emulsion method for simple poly(ethylene glycol)-block-poly(lactic-co-glycolic acid) (PEG-b-PLGA) nanoparticle (NP) synthesis. PEG-b-PLGA NP was also used entrapment of geraniin as model system phytochemical delivery. NPs were prepared using the method. yields and particle sizes obtained with without encapsulation 57.6% 134.20 ± 1.45 nm 66.7% 102.70 12.36 nm, respectively. High-performance liquid chromatography that extracted from Phyllanthus watsonii...

In this paper, the implementation of fluidic-based memristor sensor in bio-sensing application is presented. The was fabricated using sol-gel spin coating technique and chemically-modified with antidengue virus NS1 glycoprotein monoclonal antibody before being presented its ligand, glycoprotein. Four different concentrations (52 nM, 104 208 nM 416 nM) were tested on modified sensor. Each has nine wells, which function to increase binding area for trapping more viral proteins. To test whether...

Cells can sense and migrate towards higher concentrations of adhesive cues such as the glycoproteins extracellular matrix soluble growth factors. Here, we outline a method to create opposing gradients in microfluidic chamber, which is compatible with live cell imaging. A copolymer poly-L-lysine polyethylene glycol (PLL-PEG) employed passivate glass coverslips prevent non-specific adsorption biomolecules cells. Next, microcontact printing or dip pen lithography are used tracks streptavidin on...

Cardiac c-kit cells show promise in regenerating an injured heart. While heart disease commonly affects elderly patients, it is unclear if autologous cardiac are functionally competent and applicable to these patients. This study characterised (CCs) from aged mice studied the effects of human Wharton’s Jelly-derived mesenchymal stem (MSCs) on growth kinetics differentiation CCs vitro. were isolated 4-week- 18-month-old C57/BL6N directly co-cultured with MSCs or separated by transwell insert....

Cells can sense and migrate towards higher concentrations of adhesive cues such as the glycoproteins extracellular matrix soluble growth factors. Here, we outline a method to create opposing gradients in microfluidic chamber, which is compatible with live cell imaging. A copolymer poly-L-lysine polyethylene glycol (PLL-PEG) employed passivate glass coverslips prevent non-specific adsorption biomolecules cells. Next, microcontact printing or dip pen lithography are used tracks streptavidin on...

Non-structural protein 1 (NS1 protein) is becoming a commonplace biomarker for the diagnostic of early detection dengue. In this study, we sought to use label-free approach detecting NS1 by harnessing fluidic-based memristor sensor. The sensor was fabricated using sol-gel spin coating technique, which TiO2 thin film coated on surface Indium tin oxide (ITO) and glass substrate. then functionalized with glycidoxypropyl-trimethoxysilane (GPTS), acting as antibody NS1. addition target formed an...

Introduction: Nanoparticles exhibit unique features and currently at the forefront of cutting-edge research. Silver nanoparticles (AgNPs) are among most promising widely commercialised nanoproducts in various fields. The interaction these AgNPs with cells remain unclear to connect its toxicological endpoints. aim this study was investigate cellular uptake C. roseus-AgNPs hepatocellular carcinoma HepG2. Methods: HepG2 were treated mean IC50 value which 4.95±0.26 µg/mL for 24, 48 72 hours....