A5039107721- Mosquito-borne diseases and control
- Heat shock proteins research
- Vector-borne infectious diseases
- Musculoskeletal pain and rehabilitation
- Immune Response and Inflammation
- Ruminant Nutrition and Digestive Physiology
- Pain Management and Placebo Effect
- Immune Cell Function and Interaction
- Trypanosoma species research and implications
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Viral Infections and Vectors
- Toxin Mechanisms and Immunotoxins
- Virology and Viral Diseases
- Plant Virus Research Studies
- Vector-Borne Animal Diseases
- Cancer Genomics and Diagnostics
- Animal Disease Management and Epidemiology
- Genetic and phenotypic traits in livestock
- Tuberculosis Research and Epidemiology
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Research on Leishmaniasis Studies
- DNA and Nucleic Acid Chemistry
- Prenatal Screening and Diagnostics
- Herpesvirus Infections and Treatments
- Hepatitis B Virus Studies
Yale University
2021
JBS Science (United States)
2021
Centers for Disease Control and Prevention
1988-2013
Emory University
2008
Grady Health System
2008
Grady Memorial Hospital
2008
Kansas State University
1992-2007
QIMR Berghofer Medical Research Institute
2003
The University of Melbourne
2003
National Center for Infectious Diseases
2001
Erythematous rashes that are suggestive of early Lyme disease have been associated with the bite Amblyomma americanum ticks, particularly in southern United States. However, Borrelia burgdorferi causative agent disease, has not cultured from skin biopsy specimens these patients, and diagnostic serum antibodies usually found. lonestari sp nov, an uncultured spirochete, detected A. ticks by DNA amplification techniques, but its role human illness is unknown. We observed erythema migrans a...
Heat shock protein 10 (Hsp10) and heat 60 (Hsp60) were originally described as essential mitochondrial proteins involved in folding. However, both have also been shown to a number of extracellular immunomodulatory activities. Here we show that purified recombinant human Hsp10 incubated with cells vitro reduced lipopolysaccharide (LPS)-induced nuclear factor-κB activation secretion several inflammatory mediators from RAW264.7 cells, murine macrophages, peripheral blood mononuclear cells....
Abstract Purpose: PD-1/PD-L1 inhibitors are approved for multiple tumor types. However, resistance poses substantial clinical challenges. Patients and Methods: We conducted a phase I trial of CD40 agonist APX005M (sotigalimab) CSF1R inhibitor cabiralizumab with or without nivolumab using 3+3 dose-escalation design (NCT03502330). were enrolled from June 2018 to April 2019. Eligibility included patients biopsy-proven advanced melanoma, non–small cell lung cancer (NSCLC), renal carcinoma (RCC)...
Influenza virus infection activates cytolytic T lymphocytes (CTL) that contribute to viral clearance by releasing perforin and granzymes from cytoplasmic granules. Virus-specific, perforin-dependent CD8 + CTL were detected in freshly isolated cells the mouse lung parenchyma but not mediastinal lymph nodes (MLN), where they are primed, or spleen during primary influenza infection. To determine whether this difference was due low frequency incomplete maturation of effector MLN, we measured...
The first step in poliovirus replication is binding of virus to a cellular receptor. Mouse L cells, which are resistant infection because they do not bear receptor, were transformed with HeLa cell (human) DNA sensitivity at frequency approximately 1 50,000 transformants. Monoclonal antibody directed against the receptor site was used rosette assays identify poliovirus-sensitive L-cell transformants background tk+ A cloned line, CM-1, isolated that displayed surface component recognized by...
This study examined whether relationships between anger management style (anger suppression; expression) and adjustment variables for patients with chronic pain depend on patient hostility, and/or a patient's gender. A ‘spouse response model’ was also evaluated to test expression of hostile is linked infrequent positive frequent negative responses from spouses, hence poor adjustment. The sample 127 married assessed prior entry into multidisciplinary treatment program. Hierarchical multiple...
Here we show that the genes for perforin, three major T cell granzymes (A-C) and IFN-gamma are differentially expressed during primary activation of naive CD8(+) cells, kinetically at single-cell level. When CD44(low)CD62L(high)CD8(+) lymph node cells were activated with IL-2 immobilized antibodies to CD3, CD8 CD11a, expression granzyme B mRNAs was induced by day 2, increased in parallel perforin-dependent cytolytic activity. Granzyme C A transcripts not detected until 1 3 days later...
Cognitive-behavioral and physical therapies are incorporated into multidisciplinary chronic pain programs because changes in cognitions capacity may represent therapeutic processes that facilitate favorable outcome. Decreases depression, however, explain treatment responses more parsimoniously. Measures of helplessness, lifting capacity, walking endurance, severity, activity level were collected from 94 patients at pre- posttreatment 3- to 6-month follow-up evaluations. helplessness linked...
Abstract BACKGROUND. Compared with white women, African‐American (AA) women who are diagnosed breast cancer experience an excess in mortality. To improve outcomes, the authors implemented community education and outreach initiatives their center, at affiliated primary care sites, surrounding communities. They then assessed effectiveness of these internal patient navigation on stage diagnosis. METHODS. This cross‐sectional study was analysis all were and/or treated years from 2001 through...
Viruses in the family Bunyaviridae infect a wide range of plant, insect, and animal hosts. Tick-borne bunyaviruses Phlebovirus genus, including Severe Fever with Thrombocytopenia Syndrome virus (SFTSV) China, Heartland (HRTV) United States, Bhanja Eurasia Africa have been associated acute febrile illness humans. Here we sought to characterize growth characteristics genome Lone Star (LSV), an unclassified bunyavirus originally isolated from lone star tick Amblyomma americanum. LSV was able...
Human immunodeficiency virus (HIV) was detected in bedbugs (Cimex hemipterus) up to 8 d after oral exposure highly concentrated blood meals, but no replication observed. HIV did not replicate either intraabdominally inoculated or intrathoracically mosquitoes (Toxorhynchites amboinensis). The bedbug feces. Mechanical transmission of by could be demonstrated an vitro model. persistence insect on its mouthparts is one many factors necessary for mechanical nature. risk appears extremely low nonexistent.