A5075287050- Mosquito-borne diseases and control
- Insect Pest Control Strategies
- Pain Mechanisms and Treatments
- Malaria Research and Control
- SARS-CoV-2 and COVID-19 Research
- Computational Drug Discovery Methods
- Neuroscience and Neuropharmacology Research
- Insect and Pesticide Research
- Allelopathy and phytotoxic interactions
- Neuroinflammation and Neurodegeneration Mechanisms
- Cholinesterase and Neurodegenerative Diseases
- Viral gastroenteritis research and epidemiology
- Apelin-related biomedical research
- Chemical synthesis and alkaloids
- Bacteriophages and microbial interactions
- Histone Deacetylase Inhibitors Research
- Insect Resistance and Genetics
- interferon and immune responses
- Sphingolipid Metabolism and Signaling
- Nuclear Receptors and Signaling
- Ion channel regulation and function
- Acupuncture Treatment Research Studies
- Nanofluid Flow and Heat Transfer
- Weed Control and Herbicide Applications
- Plant Toxicity and Pharmacological Properties
University of Lucknow
2017-2025
Nirma University
2024-2025
Dr. Hari Singh Gour University
2025
Centers for Disease Control and Prevention
2025
Interfaith Medical Center
2024
Brookdale University Hospital and Medical Center
2024
Syracuse University
2024
Rutgers, The State University of New Jersey
2021-2024
Defence Research and Development Establishment
2013-2021
Georgia College & State University
2014-2018
Excessive activation of glutamate receptors in spinal dorsal horn neurons is a key mechanism leading to abnormal neuronal pathological pain conditions. Previous studies have shown that the enhanced by impaired glial transporter functions and proinflammatory cytokines including interleukin‐1 beta (IL‐1β). In this study, we for first time revealed activities neuropathic animals are attenuated endogenous IL‐1β. Specifically, demonstrated nerve injury results an increased expression IL‐1β PKC as...
Abstract Patients receiving paclitaxel for cancer treatment often develop an acute pain syndrome (paclitaxel‐associated syndrome, P‐APS), which occurs immediately after treatment. Mechanisms underlying P‐APS remain largely unknown. We recently reported that rodents and activation of spinal microglial toll like receptor 4 (TLR4) by penetrating into the cord is a critical event in genesis P‐APS. Our current study dissected cellular molecular mechanisms demonstrated bath‐perfusion paclitaxel,...
A novel strategy in medicinal chemistry to increase the therapeutic efficacy and reduce side effects of separate medications is creation mutual prodrugs. The production pharmacological assessment a prodrug including broad-spectrum antibiotic class fluoroquinolones nonsteroidal anti-inflammatory drug (NSAID) mefenamic acid are main topics this paper. justification for combination its ability gastrointestinal other systemic that frequently linked NSAIDs fluoroquinolones, while also potentially...
<title>Abstract</title> Type 2 diabetes mellitus (T2DM) is a chronic condition caused by decreased insulin production and increased resistance, its prevalence has 49% since 1990. Current treatments for T2DM include pharmacological agents lifestyle modifications, but they are limited their side effects cost. Herbal remedies natural products have become popular alternative as associated with fewer effects. Momordica charantia Linn. (bitter melon) member of the Cucurbitaceae family been used...
In Zambia, the true extent of SARS-CoV-2 infections is unknown because initial surveillance focused on patients with symptoms or severe disease. Antenatal sentinel had not been used to assess infection trends. The ANC COVID-19 study sought determine seroprevalence and vaccine uptake among pregnant women. We provide insight into implementation, challenges encountered, best practices, lessons learned. A repeated cross-sectional survey was implemented at 39 health facilities in four districts...
Herein, we developed a simple, efficient, cost-effective, recyclable and green approach for synthesizing imidazo[2,1-b]thiazol-5-yl)-2,4-dihydropyrano[2,3-c]pyrazole derivatives. The reaction protocol involves "HPA-Montmorillonite-KSF” as reusable heterogeneous catalyst proceeds via multicomponent (MCR). Various substituted derivatives were prepared in good to excellent isolated yields. This methodology is compatible with the gram-scale synthesis provides an efficient much improved...
Paclitaxel, a powerful anti-neoplastic drug, often causes pathological pain, which significantly reduces the quality of life in patients. Paclitaxel-induced pain includes that occurs immediately after paclitaxel treatment (paclitaxel-associated acute syndrome, P-APS) and persists for weeks to years cessation (paclitaxel induced chronic neuropathic pain). Mechanisms underlying P-APS remain unknown. In this study, we found rodents dose-dependent manner. The paclitaxel-induced within 2 hrs...
SARS-CoV-2, a human coronavirus, is the causative agent of COVID-19 pandemic. Its genome translated into two large polyproteins subsequently cleaved by viral papain-like protease and main (Mpro). Polyprotein processing essential yet incompletely understood. We studied Mpro-mediated nsp7-11 polyprotein, whose mature products include cofactors replicase, identified order cleavages. Integrative modeling based on mass spectrometry (including hydrogen-deuterium exchange cross-linking) x-ray...
Alzheimer's disease (AD) comes under progressive neurodegenerative disorders which is the leading cause of dementia affecting aged population. The available drugs for AD treatment are just palliative and not curative, further these have severe side effects. Therefore, there a significant demand novel, potent, safe molecules as anti-Alzheimer's agents with diverse mechanisms action. Benzofuran derivatives one versatile ubiquitous scaffolds being developed potential candidates against AD....
Abstract Paclitaxel is a chemotherapeutic agent widely used for treating carcinomas. Patients receiving paclitaxel often develop neuropathic pain and have reduced quality of life which hinders the use this life‐saving drug. In study, we determined role GABA transporters in genesis paclitaxel‐induced using behavioral tests, electrophysiology, biochemical techniques. We found that tonic receptor activities spinal dorsal horn were rats with induced by paclitaxel. normal controls, mainly...
Neuroinflammation and dysfunctional glial glutamate transporters (GTs) in the spinal dorsal horn are implicated genesis of neuropathic pain. The authors determined whether adenosine monophosphate-activated protein kinase (AMPK) regulates these processes rodents with pain.Hind paw withdrawal responses to radiant heat mechanical stimuli were used assess nociceptive behaviors. Spinal markers related neuroinflammation GTs by Western blotting. AMPK activities manipulated pharmacologically...
RGS10 has emerged as a key regulator of proinflammatory cytokine production in microglia, functioning an important neuroprotective factor. Although is normally expressed microglia at high levels, expression silenced vitro following activation TLR4 receptor. Given the ability to regulate inflammatory signaling, dynamic regulation levels may be mechanism tune responses. The goals current study were confirm that suppressed vivo model microglial and determine for activation-dependent silencing...
Coronavirus (CoV) nonstructural proteins (nsps) assemble to form the replication-transcription complex (RTC) responsible for viral RNA synthesis. nsp7 and nsp8 are important cofactors of RTC, as they interact regulate activity RNA-dependent polymerase other nsps. To date, no structure full-length SARS-CoV-2 nsp7:nsp8 has been published. The current understanding this is based on structures from truncated constructs, with missing electron densities, or related CoV species where share upward...
Screening of crude extracts plants facilitates the establishment highly effective extract for mosquito control. This practice should be preferred before in depth study plant rather than spending much efforts and energy detailed examinations practically ineffective extracts. In this study, leaf powders four weed were used quick screening as larvicide against III instar larvae Aedes albopictus Skuse. At same time, effect different seasons on larvicidal efficacy selection proper solvents...
Abstract Background Pregnant women are an easily accessible population for HIV and malaria surveillance. The ANC COVID-19 Surveillance study sought to determine SARS-CoV-2 seroprevalence among pregnant in Zambia. We provide insight into the challenges, good practices, successes, lessons learned from surveillance study. Methods Between September 2021 2022, 39 health facilities four districts enrolled up 20 per month aged 15–49 years attending their first antenatal care visit. Consenting...
Aedes albopictus, aegypti, Anopheles stephensi and Culex quinquefasciatus mosquitoes are recognized as medically important vectors, responsible for various disease transmissions such Dengue, Chikungunya, malaria Japanese encephalitis.These mosquito species vastly abundant in artificial containers strongly adapted to urban environment.Forest clearing, irrigation development human resettlement results large-scale increase of containers, provides types habitat breeding (1,2) .Aigbodion Uyi...