A5052531334- Cellular Mechanics and Interactions
- Lignin and Wood Chemistry
- Nuclear Structure and Function
- Effects and risks of endocrine disrupting chemicals
- Microtubule and mitosis dynamics
- Microfluidic and Bio-sensing Technologies
- Mesenchymal stem cell research
- 3D Printing in Biomedical Research
- Enzyme-mediated dye degradation
- Mitochondrial Function and Pathology
- Dyeing and Modifying Textile Fibers
- Erythrocyte Function and Pathophysiology
- Hippo pathway signaling and YAP/TAZ
- Cancer, Hypoxia, and Metabolism
- Biochemical and biochemical processes
Johns Hopkins University
2022-2025
University of Delaware
2021-2022
Newark Hospital
2021
Human mesenchymal stem cells (hMSCs) respond to mechanical stimuli, including stiffness and viscoelasticity. To date, it is unknown how extracellular fluid viscosity affects hMSC function on substrates of different While hMSCs assume an adipogenic phenotype gels low prescribed stress relaxation times, elevated sufficient bias toward osteogenic phenotype. Elevated induces Arp2/3-dependent actin remodeling, enhances NHE1 activity, promotes spreading via up-regulation integrin-linked kinase....
Chemocatalytic lignin valorization strategies are critical for a sustainable bioeconomy, as lignin, especially technical is one of the most available and underutilized aromatic feedstocks. Here, we provide first report an intensified reactive distillation–reductive catalytic deconstruction (RD-RCD) process to concurrently deconstruct lignins from diverse sources purify products at ambient pressure. We demonstrate utility RD-RCD bio-oils in high-performance additive manufacturing via...
Cells migrate in vivo through channel-like tracks. While polydimethylsiloxane devices emulate such tracks vitro, their channel walls are impermeable and have supraphysiological stiffness. Existing hydrogel-based platforms address these issues but cannot provide high-throughput analysis of cell motility independently controllable stiffness confinement. We herein develop polyacrylamide (PA)-based microchannels physiological prescribed dimensions for migration identify a biphasic dependence...
Mammalian cells sense and respond to environmental changes using a complex intelligent system that integrates chemical mechanical signals. The transduction of cues into modulates cell physiology, allowing adapt its microenvironment. Understanding how the regulatory modules interact is crucial for elucidating mechanisms mechanosensation cellular homeostasis. In this study, we find exhibit non-monotonic in volume intracellular pH when subjected physical stimuli varying degrees actomyosin...
This article explores lignin-derivable bisphenols as alternatives to bisphenol A – a suspected endocrine disruptor by investigating their structure-activity relationships with respect estrogen receptor alpha <italic>via</italic> molecular docking.
Abstract Cells migrating in confinement experience mechanical challenges whose consequences on cell migration machinery remain only partially understood. Here, we demonstrate that a pool of the cytokinesis regulatory protein anillin is retained during interphase cytoplasm different types. Confinement induces recruitment cytoplasmic to plasma membrane at poles cells, which further enhanced upon nuclear envelope (NE) rupture(s). Rupture events also enable egress predominantly RhoGEF Ect2....