A5040794808- Ubiquitin and proteasome pathways
- Fungal and yeast genetics research
- Endoplasmic Reticulum Stress and Disease
- Prion Diseases and Protein Misfolding
- Neurological diseases and metabolism
- Neurobiology and Insect Physiology Research
- Autophagy in Disease and Therapy
- Pentecostalism and Christianity Studies
- Christian Theology and Mission
- Receptor Mechanisms and Signaling
- Cellular transport and secretion
- Evaluation and Performance Assessment
- Insect and Arachnid Ecology and Behavior
- Religion, Society, and Development
- Protein Degradation and Inhibitors
- RNA Research and Splicing
- Plant and animal studies
Columbia University
2019-2021
Rockefeller University
2018-2019
New York Psychoanalytic Society and Institute
2019
New York State Psychiatric Institute
2019
Whitehead Institute for Biomedical Research
2012-2016
The University of Texas Southwestern Medical Center
2012
Abstract Protein degradation by the ubiquitin-proteasome system (UPS) is critical for neuronal development, plasticity and function. Neurons utilize microtubule-dependent molecular motors to allocate proteasomes synapses, but how are coupled motor proteins this transport regulated meet changing demand protein breakdown remains largely unknown. We show that conserved proteasome-binding PI31 serves as an adaptor directly couple with dynein light chain (DYNLL1/2). Inactivation of inhibits...
Ruth shut down the computer and stepped away from her editor’s desk. One part of day had come to an end, but another lay before her. On way home, she stopped at local hospital visit,...
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