A5100666275- Neuroscience and Neural Engineering
- EEG and Brain-Computer Interfaces
- Muscle activation and electromyography studies
- Transcranial Magnetic Stimulation Studies
- Optical Imaging and Spectroscopy Techniques
- Neural dynamics and brain function
- Neurological disorders and treatments
- Advanced Memory and Neural Computing
- Stroke Rehabilitation and Recovery
- RNA modifications and cancer
- Phytochemicals and Medicinal Plants
- Spinal Cord Injury Research
- Neurogenetic and Muscular Disorders Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Functional Brain Connectivity Studies
- Clinical Laboratory Practices and Quality Control
- Hemoglobinopathies and Related Disorders
- Photoacoustic and Ultrasonic Imaging
- Vagus Nerve Stimulation Research
- Medicinal Plants and Bioactive Compounds
- Energy Efficient Wireless Sensor Networks
- Neural and Behavioral Psychology Studies
- Nerve Injury and Rehabilitation
- Drug-Induced Hepatotoxicity and Protection
- Fuel Cells and Related Materials
Sawai ManSingh Medical College and Hospital
2024
United States Air Force Research Laboratory
2021-2023
Battelle
2015-2022
Nanyang Technological University
2022
Henry Ford Hospital
2014-2021
National Institute of Ayurveda
2021
Birla Institute of Technology, Mesra
2021
Indian Institute of Technology Mandi
2018-2020
The Ohio State University
2016-2019
The Ohio State University Wexner Medical Center
2016
Neuroprosthetics that combine a brain computer interface (BCI) with functional electrical stimulation (FES) can restore voluntary control of patients' own paralyzed limbs. To date, human studies have demonstrated an "all-or-none" type for fixed number pre-determined states, like hand-open and hand-closed. be practical everyday use, BCI-FES system should enable smooth limb movements through continuum states generate situationally appropriate, graded muscle contractions. Crucially, this...
To demonstrate naturalistic motor control speed, coordinated grasp, and carryover from trained to novel objects by an individual with tetraplegia using a brain-computer interface (BCI)-controlled neuroprosthetic.Phase I trial for intracortical BCI integrated forearm functional electrical stimulation (FES). Data reported span postimplant days 137 1478.Tertiary care outpatient rehabilitation center.A 27-year-old man C5 class A (on the American Spinal Injury Association Impairment Scale)...
Abstract Neuroprosthetic technology has been used to restore cortical control of discrete (non-rhythmic) hand movements in a paralyzed person. However, rhythmic which originate the brain but are coordinated by Central Pattern Generator (CPG) neural networks spinal cord not demonstrated previously. Here we show demonstration an artificial bypass that decodes activity and emulates CPG function allowing volitional movement. The uses combination signals recorded from brain, machine-learning...
Individuals with tetraplegia identify restoration of hand function as a critical, unmet need to regain their independence and improve quality life. Brain-Computer Interface (BCI)-controlled Functional Electrical Stimulation (FES) technology addresses this by reconnecting the brain paralyzed limbs restore function. In study, we quantified performance an intuitive, cortically-controlled, transcutaneous FES system on standardized object manipulation tasks from Grasp Release Test (GRT). We found...
Introducing neural sensing and decoding to open-loop neurostimulation technologies has the potential significantly improve diagnosis treatment of a wide variety diseases treated through bioelectronic medicine. Chronically implanted multi-electrode arrays (MEA) can be used for such are critical obtaining data high spatial temporal resolution provide accurate decoding. Signals recorded from these include local field potentials (LFP), multiunit (MU) single-unit (SU) activity. LFP offer signal...
Laboratory demonstrations of brain-computer interface (BCI) systems show promise for reducing disability associated with paralysis by directly linking neural activity to the control assistive devices. Surveys potential users have revealed several key BCI performance criteria clinical translation such a system. Of these criteria, high accuracy, short response latencies, and multi-functionality are three characteristics impacted decoding component system, algorithm that translates into...
Objective: Paralysis resulting from spinal cord injury (SCI) can have a devastating effect on multiple arm and hand motor functions. Rotary movements, such as supination pronation, are commonly impaired by upper extremity paralysis, essential for many activities of daily living. In this proof-of-concept study, we utilize neural bypass system (NBS) to decode intention cortex control combinatorial rotary movements elicited through stimulation the muscles, effectively bypassing SCI study...
Monogenic diseases are well-suited paradigms for the causal analysis of disease-driving molecular patterns. Spinal muscular atrophy (SMA) is one such monogenic model, caused by mutation or deletion survival motor neuron 1 (SMN1) gene. Although several functions SMN protein have been studied, single and pathways alone do not allow identification crucial molecules. Here, we analysed systemic characteristics SMA, using proteomics, phosphoproteomics, translatomics interactomics, from two mouse...
Understanding the long-term behavior of intracortically-recorded signals is essential for improving performance Brain Computer Interfaces. However, few studies have systematically investigated chronic neural recordings from an implanted microelectrode array in human brain.In this study, we show applicability wavelet decomposition method to extract and demonstrate utility stable features obtained a motor cortex with tetraplegia. Wavelet was applied raw voltage data generate mean power (MWP)...
Recent advances in Brain Computer Interfaces (BCIs) have created hope that one day paralyzed patients will be able to regain control of their limbs. As part an ongoing clinical study, we implanted a 96-electrode Utah array the motor cortex human. The generates almost 3 million data points from brain every second. This presents several big challenges towards developing algorithms should not only process real-time (for BCI responsive) but are also robust temporal variations and...
Abstract Background The sense of touch is a key component motor function. Severe spinal cord injury (SCI) should essentially eliminate sensory information transmission to the brain, that originates from skin innervated below lesion. We assessed hypothesis that, following SCI, residual hand transmitted can be decoded amongst competing sensorimotor signals, and used enhance via an intracortically controlled closed-loop brain-computer interface (BCI) system. Methods Experiments were performed...
The current work aims to provide conventional and high definition (HD) transcranial direct stimulation (tDCS) for the rehabilitation of patients, suffering from cerebrovascular accident or impaired hemodynamic conditions. paper presents a computational model study electric field distribution on targeted brain cortex. proposed is used find out due tDCS HD-tDCS electrode configuration. main objective this focality in terms affected surface area region In present work, different sizes (4 × 4, 3...
Abstract This paper deals with the design of universal intelligent sensor interface. Incorporating UISI makes system highly flexible because it gives freedom either attaching or detchaing various types sensor. The front end can be configured as per connected help TEDS information and firmware. There are two 10pin connector provided for analog digital sensors. also uses interfaces such I2C, SPI RS232. detail about type interface is stored in
The present article aims to fabricate spiking electrodes for EEG signal sensing and stimulating at interested region of the brain, using two different materials such as Au/AgCl Pt/AgCl, which are synthesized by simple single step precipitation method. These can also play a significant role in maintaining high focality definition transcranial direct current stimulation (HD-tDCS) brain. morphology fabricated studied field emission scanning electron microscopy (FESEM), its crystalline...
The paper presents the development of 4X1 high-definition transcranial direct current stimulation (tDCS). High-Definition Transcranial Direct Current Stimulation (HD-tDCS) has been proposed as a focal, noninvasive brain technique. In this technique, cerebral micro vessel and primary motor cortex are targeted with weak intensity (approximately 2 mA) through small array electrodes placed on scalp. mechanism technique is based polarity-dependent shift neuronal membrane potentials. These shifts...
Peripheral nerve sheath tumors in the pelvis are a severe back and buttock region pain condition. It ischaracterized by dull aching, throbbing-like, recurrent pain, often triggered movementor continuous sitting. Surgical excision is used to treat large symptomatic lesions like neurofibromas,although this procedure carries risks. Other treatment options for includemedical, peripheral blocks, interventional procedures but C-arm guided caudal epiduralblock with steroid minimally invasive...