A5052714123- Breast Lesions and Carcinomas
- Breast Cancer Treatment Studies
- MRI in cancer diagnosis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pulmonary Hypertension Research and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Skin Diseases and Diabetes
- Liver Disease Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Cancer and Skin Lesions
- Systemic Sclerosis and Related Diseases
- Effects and risks of endocrine disrupting chemicals
- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Uterine Myomas and Treatments
- Cancer Treatment and Pharmacology
- Salivary Gland Tumors Diagnosis and Treatment
- Carbohydrate Chemistry and Synthesis
- Liver Disease and Transplantation
- Glycosylation and Glycoproteins Research
- Carcinogens and Genotoxicity Assessment
- Pluripotent Stem Cells Research
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Risks and Factors
- Animal testing and alternatives
Chungbuk National University Hospital
2024
Samsung Medical Center
2024
Asan Medical Center
2024
Seoul National University Bundang Hospital
2024
Yonsei University
2024
National Cancer Institute
2024
Janssen (Switzerland)
2024
Cliniques Universitaires Saint-Luc
2007-2023
UCLouvain
2000-2022
Johnson & Johnson (United States)
2021
Endothelin-1 is a potent vasoconstrictor and smooth-muscle mitogen. In preliminary study, the orally administered dual endothelin-receptor antagonist bosentan improved exercise capacity cardiopulmonary hemodynamics in patients with pulmonary arterial hypertension. The present trial investigated effect of on larger number compared two doses.
A previous trial of bosentan in idiopathic pulmonary fibrosis (IPF) showed a trend to delayed IPF worsening or death. Also, improvements some measures dyspnea and health-related quality life were observed.To demonstrate that delays death.Prospective, randomized (2:1), double-blind, placebo-controlled, event-driven, parallel-group, morbidity-mortality adults with less than 3 years' duration, confirmed by surgical lung biopsy, without extensive honeycombing on high-resolution computed...
Rationale: Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal lung disease lacking effective treatment.Objectives: To determine the effects of bosentan on exercise capacity and time to progression in patients with IPF.Methods: In double-blind, multicenter trial, IPF were randomized receive oral 62.5 mg twice daily for 4 weeks, increased 125 thereafter, or placebo, 12 months longer. The primary efficacy endpoint was change from baseline up Month capacity, as measured by modified...
BackgroundAmivantamab plus lazertinib (amivantamab–lazertinib) has shown clinically meaningful and durable antitumor activity in patients with previously untreated or osimertinib-pretreated EGFR (epidermal growth factor receptor)–mutated advanced non–small-cell lung cancer (NSCLC).MethodsIn a phase 3, international, randomized trial, we assigned, 2:2:1 ratio, EGFR-mutated (exon 19 deletion L858R), locally metastatic NSCLC to receive amivantamab–lazertinib (in an open-label fashion),...
Hepatic Perfusion Parameters in Chronic Liver DiseaseDynamic CT Measurements Correlated with Disease SeverityBernard E. Van Beers1, Isabelle Leconte1, Roland Materne1, Anne M. Smith1, Jacques Jamart2 and Yves Horsmans3Audio Available | Share
OBJECTIVE. Our purpose was to determine the contribution of mammography followed by sonography for detection nonpalpable breast cancers in Breast Imaging Reporting and Data System (BI-RADS) density grades 1–4 breasts, 1 2 3 4 breasts.
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with poor prognosis, which characterised by destruction of normal architecture and excessive deposition extracellular matrix. The heterogeneity progression in patients IPF poses significant obstacles to patient care prevents efficient development novel therapeutic interventions. Blood biomarkers, reflecting pathobiological processes the lung, could provide objective evidence underlying disease. Longitudinally...
To determine whether computed tomography (CT) can depict liver hemodynamic changes caused by occult hepatic micrometastases in rat.Liver (mean diameter, 500 micrometer +/- 300) were produced seven BD IX rats injecting 10(7) DHDK12 PROb colorectal carcinoma cells into the spleen. Macrometastases 7 mm 3) four other rats. Five normal studied as controls. CT images obtained every 300 msec for 30 seconds during injection of 1 mL per kilogram body weight contrast medium. The time-attenuation...
To assess the performance of a predictive model non-response to neoadjuvant chemotherapy (NAC) in patients with breast cancer based on texture, kinetic, and BI-RADS parameters measured from dynamic MRI.Sixty-nine invasive ductal carcinoma who underwent pre-treatment MRI were studied. Morphological biological markers measured. Pathological complete response was defined as absence situ nodes. non-responders, partial responders identified. Dynamic imaging performed at 1.5 T 3D axial T1W GRE...
8516 Background: Afatinib is the only EGFR tyrosine kinase inhibitor (TKI) approved to treat patients (pts) with EGFR-mutated advanced NSCLC harboring atypical mutations (eg, S768I, L861Q, G719X), excluding exon 20 insertion (Ex20ins). In a retrospective analysis of 38 TKI-naïve pts, 27 had response afatinib, median duration (mDoR) 11.1 months (mo) and progression-free survival (mPFS) 10.7 mo (Yang Lancet Oncol 2015;16(7):830-8). Amivantamab (ami) an EGFR- MET bispecific antibody immune-cell...
Various liver diseases lead to significant alterations of the hepatic microcirculation. Therefore, quantification perfusion has potential improve assessment and management diseases. Most methods used quantify are invasive or controversial. This paper describes validates a non-invasive method for using computed tomography (CT). Dynamic single-section CT was performed after intravenous bolus administration low-molecular-mass iodinated contrast agent. Hepatic, aortic portal-venous time—density...
Idiopathic pulmonary fibrosis (IPF) is a fatal disease for which no effective treatment exists. In the present study, 12 IPF patients underwent analysis of gas exchange properties using multiple inert elimination technique on day 1 before and after administration 125 mg bosentan, dual endothelin antagonist. Following this, received chronic weeks (62.5 b.i.d. in week 1, thereafter). The primary objective was to determine effect bosentan (day 1) oxygen saturation minute ventilation (week 2)....
Insulin receptor (IR) is a glycoprotein possessing N-linked oligosaccharide side chains on both alpha and beta subunits. The present study focuses for the first time potential contribution of oligosaccharides subunit in processing, structure, function insulin receptor. To investigate this point, mutant (IR N1234) was obtained by stable transfection into Chinese hamster ovary cells an IR cDNA modified site-directed mutagenesis four N-glycosylation sites (Asn-X-Ser/Thr) subunit. mutated...
Predicting embryotoxicity of pharmaceutical compounds or industrial chemicals is crucial for public safety. Conventional studies which monitor embryo–fetal development in rats and rabbits are costly time consuming. Alternative assays simpler less being pursued. The purpose this research was to assess the capacity zebrafish assay predict mammalian plasma levels that embryotoxic. Previously published data on rat associated with were used guide concentration ranges each 25 dissolved media...
Purpose: The purpose of this work was to assess the natural course biopsy-proven focal nodular hyperplasia (FNH). Method: Eighteen FNHs in 14 patients (12 women and 2 men) who were followed for at least 6 months with CT and/or MRI included study. volume lesions calculated twice by two observers using summation areas method. Intra-and interobserver variability assessed intraclass correlation coefficients. Longitudinal data analysis performed generalized estimating equations. Results: FNH...
No therapy is known to improve health-related quality of life (HRQoL) or dyspnoea in patients with idiopathic pulmonary fibrosis. The present study investigated longitudinal changes HRQoL and explored the effects bosentan on these end-points during Bosentan Use Interstitial Lung Disease (BUILD)-1 trial. In total, 154 subjects received oral (n = 71) placebo 83). Changes from baseline month (M) 6 up M12 were measured using St George’s Respiratory Questionnaire (SGRQ), 36-item short-form health...
Expression of both basic fibroblast growth factor (bFGF) and FGF receptors (FGFR) by vascular smooth muscle cells suggests that autocrine signaling mechanisms may have important functions. Inhibition cell bFGF expression provokes apoptosis, suggesting endogenous generates an anti-apoptotic signal. The purpose this study was to determine whether the survival function requires through FGFR. A recombinant adenovirus encoding a truncated murine FGFR-1 lacking kinase domain (DN-FGFR) efficiently...
The functional role of the oligosaccharide chains linked to insulin receptor (IR) beta subunit was investigated by site-directed mutagenesis each 4 acceptor asparagines (N1 N4 from amino carboxyl terminus) and stable expression receptors in CHO cells. All mutant are expressed normally at cell surface, bind with similar affinity, but have a smaller molecular mass, defect ligand-induced internalization as compared wild type receptor. In terms activation signal transduction, N1 N2 mutants...