A5084260587- Magnetic properties of thin films
- Plant Physiology and Cultivation Studies
- IL-33, ST2, and ILC Pathways
- Liver Disease Diagnosis and Treatment
- Hormonal Regulation and Hypertension
- Plant Reproductive Biology
- Cancer therapeutics and mechanisms
- Eosinophilic Esophagitis
- Blood Pressure and Hypertension Studies
- Phonocardiography and Auscultation Techniques
- Renin-Angiotensin System Studies
- Systemic Lupus Erythematosus Research
- Geology and Paleoclimatology Research
- Iron oxide chemistry and applications
- Horticultural and Viticultural Research
- Magnetic Properties and Synthesis of Ferrites
- Renal Diseases and Glomerulopathies
- Plant Pathogens and Fungal Diseases
- Cryptography and Data Security
- Internet Traffic Analysis and Secure E-voting
- Metabolism and Genetic Disorders
- DNA Repair Mechanisms
- Plant tissue culture and regeneration
- Cardiac Imaging and Diagnostics
- Privacy-Preserving Technologies in Data
Jichi Medical University
2008-2024
Institute of Fruit Tree and Tea Science
2013-2024
Yamasa Corporation (Japan)
2023-2024
National Agriculture and Food Research Organization
2007-2024
Yokohama Minami Kyosai Hospital
2023
Life Science Institute
2022
Fuji Oil (Japan)
2022
Shimizu (Japan)
2015-2021
National Institute of Information and Communications Technology
2014-2017
Shizuoka Prefectural Gotemba Minami High School
2017
Abstract The bcl-x gene, a bcl-2 family member, is highly regulated during lymphoid development, and its expression modulates apoptosis in other cell populations. Several forms of mRNAs with different biologic functions have been described rodents humans. In this study, we determined the organization promoter region mouse gene an effort to understand molecular basis for mRNA species identified tissues. We show that maps distal chromosome 2 at approximately 89 cM, exhibits three-exon...
Abstract The nucleotide-binding oligomerization domain–like receptor family pyrin domain containing 3 (NLRP3) inflammasome is a molecular platform that induces caspase-1 activation and subsequent IL-1β maturation, implicated in inflammatory diseases; however, little known about the negative regulation of NLRP3 activation. In this article, we identified an E3 ligase, Ariadne homolog 2 (ARIH2), as posttranslational regulator activity macrophages. ARIH2 interacted with via its NACHT (aa...
Most indigenous citrus varieties are assumed to be natural hybrids, but their parentage has so far been determined in only a few cases because of wide genetic diversity and the low transferability DNA markers. Here we infer using simple sequence repeat indel markers developed from various genome resources. Parentage tests with 122 known hybrids selected certify among those hybrids. Identity confirm that most variant strains mutants, find four types kunenbo (Citrus nobilis) three tachibana...
Abstract Background: Proliferating cell nuclear antigen (PCNA) is a ring‐shaped protein known as processivity factor of DNA polymerase δ. In addition to this role, PCNA interacts with number other proteins increase their local concentration at replicated sites. cytosine methyltransferase 1 (Dnmt1), which preserves epigenetic signals by completing the methylation hemimethylated after replication, has been indicated one these binding previous work. However, molecular mechanisms and functional...
Components of ORC (the origin recognition complex) are highly conserved among eukaryotes and thought to play an essential role in the initiation DNA replication. The level largest subunit human (ORC1) during cell cycle was studied several lines with a specific antibody. In all lines, ORC1 levels oscillate: starts accumulate mid-G1 phase, reaches peak at G1/S boundary, decreases basal S phase. contrast, other subunits (ORCs 2–5) remain constant throughout cycle. oscillation ORC1, or cycle,...
Somatic embryogenesis in nucellar tissues is widely recognized to induce polyembryony major citrus varieties such as sweet oranges, satsuma mandarins and lemons. This capability for apomixis attractive agricultural production systems using hybrid seeds, many studies have been performed elucidate the molecular mechanisms of various types apomixis. To identify gene responsible somatic citrus, a custom oligo-DNA microarray including predicted genes polyembryonic locus was used compare...
Abstract: Background: Recently, it has been reported that interleukin 4 (IL‐4) and 13 (IL‐13) directly activate fibroblasts promote fibrosis. In the process of hepatic fibrosis, effects these cytokines on stellate cells (HSCs) are not well known. Methods: We evaluated IL‐4 IL‐13 collagen production proliferation LI90, a cell line. also examined whether interferon (IFN) interferes with expression collagen, since IFN to clinically suppress Results: The receptor complex for was IL‐4Rα/IL‐13Rα1...
Proliferating cell nuclear antigen (PCNA), a eukaryotic DNA replication factor, functions not only as processivity factor for polymerase δ but also binding partner multiple other factors. To understand its broad significance, we have carried out systematic studies of PCNA-binding proteins by combination affinity chromatography and mass spectrometric analyses. We detected more than 20 specific protein bands various intensities in fractions bound to PCNA-fixed resin from human lysates...
Tributyltin chloride (TBT), an endocrine-disrupting chemical, has been used as a heat stabilizer, agricultural pesticide, and component of antifouling paints. In this study, we investigated the concentration dependence mechanisms tributyltin cytotoxicity in PC12 cells. Exposure cells to both 500 nM 2 microM increased number showing nuclear fragmentation, typical apoptotic feature, activated caspase-3. The peak Ca(2+) tributyltin-treated was higher than that intracellular increase induced by...
A new preparation process for sputtered γ-Fe <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> O xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> thin film disks has been developed. The is composed of Fe xmlns:xlink="http://www.w3.org/1999/xlink">4</inf> formation by reactive sputtering and oxidation to film. characteristic the that single phase formed directly an Fe-alloy target in Ar-O atmosphere. magnetic properties recording results...
Chronic myeloid leukemia (CML) is induced by the expression of fused tyrosine kinase BCR-ABL, which caused a chromosomal translocation. BCR-ABL inhibitors have been used to treat CML; however, acquisition resistance CML cells during treatment serious issue. We herein demonstrated that RNA helicase DDX5 in K562 derived from patients manner was dependent on its activity, resulted cell proliferation and survival. The knockout decreased BIRC5 (survivin) activated caspase 3, leading apoptosis...