Pigeon pea (Cajanus cajan) seeds are widely consumed as a staple food in numerous countries, with leaves recognized for various medicinal values, particularly flavonoid production. Therefore, this study aimed to investigate leaf production pigeon peas through recurrent harvesting at different heights and the application of cow manure rate. The experiment was carried out Split Plot Design, main plot consisting three levels 0, 15, 30 tons/ha, while subplots comprised no pruning, 100 125 cm...

Abstract Diabetes mellitus is a metabolic condition marked by heightened levels of blood glucose, also known as hyperglycemia. Hyperglycemia leads to oxidative stress, which promotes some complications, both microangiopathy and macroangiopathy impairments. This study assesses the antidiabetic activity Z. officinale (ginger) C. cajan (pigeon pea) leaf extracts in alloxan-diabetic rats. used 25 male Rats were allocated into five groups: negative control group (C), diabetes (DM), DM treated...

This investigation is aimed at evaluating the polyphenol profile, antioxidant, α-glucosidase and α-amylase inhibitory hypoglycemic activities of Acalypha hispida leaf extract in vivo. Powdered leaves were macerated with 70 96 % ethanol decocted distilled water. The filtrates evaporated to obtain dry extracts. extracts found have a profile (ultraperformance liquid chromatography quadrupole time-of-flight) exhibit antioxidant activity (2,2-diphenyl-1-picrylhydrazyl) inhibition...

Safety evaluation of polyherbal Unani formulation -Deedan in Wistar ratsKhalid Ghazanfar, Showkat A. Dar, Tazeen Nazir, Irfat Ara, Akbar Masood, Seema

Acalypha hispida Burm.f. is commonly used as an ornamental plant known for pharmacological effects. The nanoscale extract increases bioavailability and bioactivity. This research aimed to produce characterize nanopowder of A. leaves. Powdered leaves were macerated in 96% ethanol, then was evaporated the spry dryer. Nanopowder produced using planetary ball milling at 5000 rpm different times, namely 5 minutes (nanopowder A), 10 B), 40 C). extracts evaluated a particle size analyzer, scanning...

This research aims to evaluate the safety of ethanolic extract Acalypha hispida (A. hispida) leaves with acute toxicity test using 15 female rats strain Sprague-Dawley. A single dose different doses (2, 4, 8, and 16 g/kg body weight) was administrated orally, theobservation conducted for 14 days. The results revealed that A. relatively harmless (LD50 BW), did not affect weight, show clinical signs during observation periods. parameters blood serumbiochemistry all extract-treated groups...

Objective: This study aimed to characterize Dumb cane extract nanoemulsion for injection preparation and test its activity as an inflammation-inducing agent in rat intraplantar with IL-6 TNF-alpha parameters blood serum well the swelling response paw. Methods: Nanoemulsion was made from emulsion base of olive oil, coconut tween 80 propylene glycol, water injection, varying concentrations (1%, 2%, 4%) using vortex mixing sonication methods. The characterization included particle size, zeta...

The global prevalence of diabetes mellitus was 537 million in 2021 and is projected to increase 783 by 2045. Diabetes progression also associated with histone modifications. Previous studies have reported that Acalypha hispida leaves are rich flavonoids phenolic acids, which antihyperglycemic activity. Recently, we produced a nanoextract A . leaf contains bioactive compounds antidiabetic effects. However, there were no the efficacy A. extract nanoextract. Hence, aimed evaluate effects on...

Nanotechnology has rapidly grown in various research fields to treat oxidative stress diabetes, including medicine and phytomedicine. Previous showed that Acalypha hispida strong antioxidant activity vitro anti-hyperglycemic vivo. However, the size reduction crude extract should be applied decrease doses increase efficacy. The objective was evaluate nano-extract of A. leaves on Cu,Zn-SOD content pancreas diabetic rats. analysis carried out using immunohistochemistry. rats (DMC) significantly...

The combination of Cajanus cajan leaf and Zingiber oficinale rhizome extract resulted in a greater hypoglycemic effect than the single both extracts. However, no research reported toxic So, this study assessed toxicity C. leaves Z. officinale male female Sprague-Dawley rats. Thirty thirty rats were used study. randomly assigned to six groups ten per group (five males five females): control treatment three-dose treated for 28 days-treatment periods. satellite extended 14 daysrecovery doses...

Evaluation of phytoconstituents, nephro-protective and antioxidant activities Clitoria ternateaK.Sarumathy, M.S.Dhana Rajan, T.Vijay, J.Jayakanthi

Getah kemenyan dengan genus Boswellia telah lama digunakan secara tradisional pada beberapa penyakit. Kandungan salah satunya adalah asam boswellic. Asam boswellic memiliki aktivitas neuroprotektif dan antiinflamasi. Beberapa jenis yang paling banyak diteliti mengenai efek farmakologi 11-keto-β-boswelik (KBA), asetil-11-keto-β-boswellik (AKBA), β-boswelik (βBA). βBA efektivitas permeabel terhadap Blood Brain Barrier (BBB) dibandingkan lainnya. Oleh karena itu, potensi lebih besar dalam...