The aim of this study was to investigate the cellular/biochemical mechanisms by which cisplatin (CIS) causes testicular toxicity. We evaluated role inducible nitric oxide synthase (iNOS) expression, mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-kB) activation in pathogenesis damage induced CIS, investigated effects curcumin (CMN) against CIS-induced injury rats.Rats were divided into five equal groups: (1) control, (2) (3) CMN, (4) CIS + CMN (5) corn oil. After...

Background and aims. Gentamicin (GM) is still considered to be an important antibiotic against life-threatening, gram-negative bacterial infections despite its known nephrotoxic effects. We aimed evaluate the potential protective effect of atorvastatin (ATO) GM-induced nephrotoxicity in rats. Materials methods. The rats were randomly divided into five groups six animals each: control, GM (100 mg/kg/day), ATO (10 + ATO, Vehicle. Kidney function tests, tissue oxidative stress parameters,...

Purpose: To investigate whether melatonin (MLT) treatment has any protective effect on unilateral ureteral obstruction (UUO)–induced kidney injury in rats. Materials and Methods: Six animals were included each of the following five groups: group 1, sham operation but no treatment; 2, ligation 3, + MLT; 4, 5, +5% ethanol (the vehicle MLT). The injected dose MLT was 1 mg/kg/day (intraperitoneal). daily, beginning 5 days before or until 10 after it. At UUO, all rats sacrificed with high-dose...

Spontaneous closure of rectourethral fistulas (RUF), often seen after radical prostatectomy (RP), is rare, and most cases require surgical repair. In recent years, the perineal approach has become preferred technique. This study aimed to retrospectively present functional results transperineal buccal mucosal graft repair RUFs developed RP. Twenty-four patients who RUF secondary RP between January 2016 May 2023 were included in study. Our excluded had previous unsuccessful fistula treatment...

We evaluated the genotypes of serotonin transporter gene (5-HTT) in patients with premature ejaculation (PE) to determine role genetic factors etiopathogenesis PE and possibly identify patient subgroups.A total 70 controls were included this study.All men heterosexual, had no other disorders either married or a stable relationship.PE was defined as that occurred within 1 min vaginal intromission.Genomic DNA from analyzed using polymerase chain reaction, allelic variations promoter region...

Objective: The purpose of our study was to compare Vacuum-assisted closure (VAC) and conventional dressings in the wound therapy Fournier’s gangrene (FG). Materials methods: evaluated 54 patients, retrospectively. Following initial removal necrotic devitalized tissue, Group I patients wounds were covered with antiseptic continued be treated dressings. In II VAC initiated. collected data compared between groups. Results: difference two groups statistically significant terms number daily...

KLOTHO, a type-1 transmembrane protein with glucurodinase activity, is expressed in tissues responsible for calcium homeostasis such as the kidney, parathyroid gland and epithelium of choroid plexus brain. Given emerging evidence indicating novel regulatory function KLOTHO renal phosphate homeostasis, present study aims to investigate association between genetic polymorphisms kidney stone (KS).KLOTHO gene G395A promoter region, F252V exon 2, C1818T 4 were investigated 108 patients formation...

To evaluate the role of inducible nitric oxide synthase (iNOS), selective nuclear factor-kB (NF-kB), and p38-mitogene-activated protein kinase (p38-MAPK) on hyperoxaluria-induced oxidative stress stone formation in rat kidneys. The rats were divided into five groups: group 1, control group; 2: ethylene glycol (EG) 3: EG + pomegranate juice (PJ)-low 4: PJ-middle 5: PJ-high group. Rats sacrificed 7, 15, 45 days. iNOS expression, p65-NF-kB p38-MAPK activity, markers evaluated kidney. Crystal...

We aimed to evaluate the effectiveness of paroxetine and tadalafil combination in treatment premature ejaculation (PE). A total 150 primary (lifelong)PE patients were randomly distributed into three groups 50 each. Group 1 received 20 mg every day for month, 2 on demand h before intercourse, 3 intercourse. Intravaginal ejaculatory latency times (IELT) scores evaluated at baseline, end first month therapy after discontinuation treatment, while International Index Erectile Function (IIEF)...

The objective of this study was to evaluate inducible nitric oxide synthase (iNOS) and nuclear factor-kappaB inhibitor (NF-kappaB) expression the potential chemoprotective effects an NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), against cisplatin-induced testicular damage in rats. Rats were divided into 4 equal groups: group 1, control; 2, injected with cisplatin (CIS) for 5 days (7 mg/kg/day intraperitoneally [IP]); 3, PDTC alone; 4, CIS plus (100 mg/kg IP). Body weights, plasma...

To compare the outcomes of flexible ureterorenoscopy (F-URS) and mini-percutaneous nephrolithotomy (mini-PNL) in treatment lower calyceal stones smaller than 2 cm. Patients who underwent F-URS mini-PNL for cm between March 2009 December 2014 were retrospectively evaluated. Ninety-four patients divided into two groups by modality: (Group 1: 63 patients) 2: 31 patients). All preoperatively diagnosed with intravenous pyelography or computed tomography. Success rates at postoperative first month...

OBJECTIVE To explore the association between promoter polymorphism (that influences transcriptional level) of matrix metalloproteinase‐1 (MMP‐1, associated with tumour cell invasion and metastasis) bladder cancer in a Turkish population. PATIENTS, SUBJECTS AND METHODS The MMP‐1 was assessed 102 transitional carcinomas (50 Ta, 52 T2–4) 94 age‐, smoking‐ gender‐matched healthy volunteers. polymerase chain reaction (PCR) assay used to determine genotypes. Genomic DNA for extracted from...

Dapoxetine hydrochloride is a selective serotonin reuptake inhibitor and the first drug approved for on-demand treatment of premature ejaculation (PE). Our objective in this study was to characterize efficacy dapoxetine (30 60 mg) daily paroxetine (20 usage treating PE. We conducted 1 month involving total 150 patients. Patients were divided into three groups 50. Group treated with mg), 2 (60 3 mg). outcome measurement increased from baseline intravaginal ejaculatory latency time (IELT)...

Minimally invasive techniques are increasingly evolving and preferred to reduce surgical induced morbidity mortality minimize the challenges of techniques. Especially radical perineal prostatectomy (RPP) includes some like working in a deep narrow space challenging ergonomics for surgeons. Because these issues open RPP is still performed experienced centers. In order difficulties, robot- assisted (r-RPP) developed. this study, we report our first clinical results r-RPP.Between November 2016...

We compared the outcomes of robotic-assisted radical perineal prostatectomy (r-PRP) versus transperitoneal laparoscopic (RARP).Between November 2016 and September 2017 in our center, 40 patients underwent r-PRP, RARP. All also multiparametric magnetic resonance imaging (mpMRI) to exclude cases with locally advanced disease. Patients localized prostate cancer (C-T2N0M0) were included study. The exclusion criteria contraindications for undergoing robotic prostatectomy; Gleason score ≥4+3;...