A5046939425- Corneal surgery and disorders
- Traumatic Ocular and Foreign Body Injuries
- Glaucoma and retinal disorders
- Connexins and lens biology
- Traumatic Brain Injury and Neurovascular Disturbances
- Intraocular Surgery and Lenses
- Ophthalmology and Visual Impairment Studies
- Optical measurement and interference techniques
- Ocular Surface and Contact Lens
- Disaster Response and Management
- Retinal and Optic Conditions
- Tribology and Lubrication Engineering
- Corneal Surgery and Treatments
- Retinal Development and Disorders
- Automotive and Human Injury Biomechanics
- Proteoglycans and glycosaminoglycans research
- Retinal Imaging and Analysis
- Retinal and Macular Surgery
- Facial Trauma and Fracture Management
- Heat shock proteins research
- Ocular and Laser Science Research
- Ophthalmology and Eye Disorders
- Connective tissue disorders research
- Spaceflight effects on biology
- Hippo pathway signaling and YAP/TAZ
The Ohio State University
2016-2025
Wright State University
2024
University of York
2023
The Ohio State University Wexner Medical Center
2020-2022
Weill Cornell Medicine
2021-2022
Cornell University
2021-2022
Visual Sciences (United States)
2019
Northeastern University
2017
The University of Texas at San Antonio
2012-2016
Washington University in St. Louis
2006-2012
To describe the effect of varying scleral stiffness on biomechanical deformation response cornea under air-puff loading via a finite-element (FE) model.
Traumatic optic neuropathy (TON) is a common cause of irreversible blindness following head injury. TON characterized by axon damage in the nerve followed retinal ganglion cell death days and weeks At present, no therapeutic or surgical approach has been found to offer any benefit beyond observation alone. This due part lack translational animal models suitable for understanding mechanisms evaluating candidate treatments. In this study, we developed rat model which eye rapidly rotated,...
An injectable, in situ physically and chemically crosslinkable gellan hydrogel is synthesized via thiolation. The thiolation does not alter the gellan's unique 3-D conformation, but leads to a lower phase transition temperature under physiological conditions stable chemical crosslinking. synthesis hydrogels are characterized by (1)H NMR, FT-IR, CD, or rheology measurements. injectability tissue culture cell viability also tested. thiolated exhibits merits, such as ease for injection, quick...
Refined data analysis was performed to assess binocular visual field conservation in patients with bilateral glaucomatous damage determine whether unilateral loss is random, anatomically symmetric, or nonrandom relation the fellow eye.This a case-control study of 47 consecutive bilaterally severe glaucoma; each right eye locus paired randomly selected coisopteric left loci, 760,000 (10,000 complete sets 76 loci) such iterations per subject. The potential role anatomic symmetry also assessed...
Latent-transforming growth factor beta-binding protein 2 (LTBP-2) is a major component of arterial and lung tissue the ciliary zonule, system extracellular fibers that centers suspends lens in eye. LTBP-2 has been implicated previously development microfibrils, although its exact role remains unclear. Here, we analyzed three-dimensional structure zonule wild type mice used knockout model to test contribution mechanical properties. In types, zonular had diameters 0.5–1.0 micrometers, with an...
Abstract Many disease pathologies, particularly in the eye, are induced by oxidative stress. In particular, injury to optic nerve (ON), or neuropathy, is one of most common causes vision loss. Traumatic neuropathy (TON) occurs when ON damaged following blunt penetrating trauma either head eye. Currently, there no effective treatment for TON, only management options, namely systematic delivery corticosteroids and surgical decompression nerve. Unfortunately, neither option alleviates...
The continuous growth of the lens throughout life may contribute to onset age-related conditions in (i.e., presbyopia and cataract). Volumetric is result proliferation epithelial cells (LECs). driving factors controlling LEC are not well understood. This study tested hypothesis that mechanical stretching modulates proliferation.Biomechanical regulation was investigated by culturing whole porcine lenses connective tissues ex vivo under varying physiologically relevant using a bespoke device....
The lifesaving chemotherapy and radiation treatments that allow patients to survive cancer can also result in a lifetime of side-effects, including male infertility. Infertility survivors is thought primarily from killing the spermatogonial stem cells (SSCs) responsible for producing spermatozoa since SSCs turn over slowly are thereby sensitive antineoplastic therapies. We previously demonstrated cytokine granulocyte colony-stimulating factor (G-CSF) preserve spermatogenesis after alkylating...
Connexins and aquaporins play essential roles in maintaining lens homeostasis transparency there is a close physical functional relationship between these two proteins. Aquaporin 0 (AQP0), addition to its role water transport the lens, acts as cell-cell adhesion molecule. Recently, we showed new of connexin (Cx) 50 mediating adhesion. However, cooperative proteins vivo have not been reported.We generated an AQP0/Cx50 double knockout (dKO) mouse model. Light, fluorescence, transmission thin...
Purpose.: We qualitatively describe the anatomic features of primary blast ocular injury observed using a postmortem porcine eye model. Porcine eyes were exposed to various levels energy determine optimal conditions for future testing. Methods.: studied 53 enucleated eyes: 13 controls and 40 range levels. Eyes preassessed with B-scan ultrasound biomicroscopy (UBM) ultrasonography, photographed, mounted in gelatin within acrylic orbits, monitored high-speed videography during blast-tube...
Purpose The biomechanical properties of the vitreous humor and replication these to develop substitutes for have rapidly become topics interest over last two decades. In particular, behavior as a viscoelastic tissue has been investigated identify its role in variety processes related biotransport, aging, age-related pathologies vitreoretinal interface.Methods A thorough search review peer-reviewed publications discussing both human animal specimens was conducted. Findings on effects...
Debate regarding the mechanisms of how eye changes focus (accommodation) and why this ability is lost with age (presbyopia) has recently been rejoined due to advent surgical procedures for correction presbyopia. Due inherent confounding factors in both vivo vitro measurement techniques, mechanical modeling behavior ocular lens accommodation attempted settle debate. However, a paucity reliable property measurements proven problematic development successful model accommodation. Instrumented...
A computational model of the porcine eye was developed to simulate primary blast exposure. This facilitates understanding blast-induced injury mechanisms.A used effects loading for comparison with experimental findings from shock tube experiments. The exposed overpressure-time histories measured during physical Deformations and mechanical stresses within various ocular tissues were then examined correlation pathological in experiments.Stresses strains experienced a event increase as severity...
The objective of this study was to determine whether clinically significant ocular trauma can be induced by a survivable isolated primary blast using live animal model. Both eyes 18 Dutch Belted rabbits were exposed various low-level overpressures in large-scale shock tube simulating similar an improvised explosive device. Eyes the blast-exposed (as well as five control rabbits) thoroughly examined before and after detect changes. Clinically changes corneal thickness arose immediately...