A5027320354- Forensic Toxicology and Drug Analysis
- Poisoning and overdose treatments
- Opioid Use Disorder Treatment
- Sepsis Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Emergency and Acute Care Studies
- Renal function and acid-base balance
- Cannabis and Cannabinoid Research
- Trauma and Emergency Care Studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Hip and Femur Fractures
- Clinical Reasoning and Diagnostic Skills
- Mental Health and Patient Involvement
- Patient-Provider Communication in Healthcare
- Empathy and Medical Education
- Substance Abuse Treatment and Outcomes
- Methemoglobinemia and Tumor Lysis Syndrome
- Respiratory Support and Mechanisms
- Metabolomics and Mass Spectrometry Studies
- Psychedelics and Drug Studies
Harry Perkins Institute of Medical Research
2017-2025
The University of Western Australia
2017-2025
Royal Perth Hospital
2015-2025
Hospital Research Foundation
2022-2025
RPH Research Foundation
2022-2025
Austin Health
2023
North Metropolitan Health Service
2021-2023
East Metropolitan Health Service
2021-2023
Government of Western Australia Department of Health
2017
Armadale Health Service
2017
Abstract Aims This study aimed to describe clinical features and outcomes of patients presenting the emergency department with analytically confirmed methamphetamine intoxication, determine blood concentration test its association findings. Design The Western Australian Illicit Substance Evaluation (WISE) is a prospective observational cohort study. Setting Royal Perth Hospital Emergency Department, Perth, Australia, between 2016 2018. Participants Patients suspected be intoxicated...
Guidelines recommend an initial intravenous (IV) fluid bolus of 30 ml/kg isotonic crystalloid for patients with sepsis and hypotension. However, there is a lack evidence from clinical trials to support this. Accumulating observational data suggest harm associated the injudicious use fluids in sepsis. There currently equipoise regarding liberal or restricted fluid-volume resuscitation as first-line treatment sepsis-related A randomised trial comparing these two approaches is, therefore,...
The unprecedented rise in synthetic drugs, many containing unknown toxic agents, has made timely analytical diagnosis more difficult, and reduced the confidence of clinicians providing ED management to this population patients. This also impacted quality evidence informing harm reduction responses. Emerging Drugs Network Australia (EDNA) brings together emergency physicians, toxicologists forensic laboratories establish a standardised toxicosurveillance system Australia.Blood analysis...
Abstract Introduction Gamma‐hydroxybutyrate (GHB) use is associated with high risk of accidental overdose. This study examined the pre‐hospital circumstances, demographic characteristics and clinical outcomes analytically confirmed GHB emergency department (ED) presentations in Western Australia (WA). Methods case series was conducted across three WA EDs involved Emerging Drugs Network Australia, from April 2020 to July 2022. Patient demographics, drug exposure circumstances ED presentation...
Abstract Objective An ever‐increasing number of novel psychoactive substances are being detected worldwide. These emerging drugs have been demonstrated to cause toxicity in clusters, and deaths reported. We urgently need learn more about their effects. report the protocol for Western Australian Illicit Substance Evaluation (WISE) study, a research project investigating illicit drug use ED. Methods Patients can be enrolled if treating clinician strongly suspects they currently intoxicated...
Abstract Purpose To investigate the effect of IV fluid resuscitation on endothelial glycocalyx (EG) shedding and activation vascular endothelium inflammation. Materials methods A planned biomarker sub-study REFRESH trial in which emergency department (ED) patients) with suspected sepsis hypotension were randomised to a restricted fluid/early vasopressor regimen or later vasopressors if required (usual care). Blood samples collected at randomisation (T0) 3 h (T3), 6 (T6)- 24 (T24) for...
Presentations related to illicit drugs are a feature of emergency department practice. Clinicians may form belief that patient is intoxicated with based on self-report, clinical features presentation and the local prevalence drug use. But evidence accuracy this assessment lacking. The Western Australian Illicit Substance Evaluation (WISE) study enrolled patients believed by their treating clinician be drugs, analysis aims evaluate validity belief.A blood sample was taken arrival details...
Abstract Introduction The often unknown nature of acute drug intoxication, especially with illicit drugs and emerging novel psychoactive substances, can present a significant challenge for emergency clinicians. Less experienced clinicians are particularly vulnerable to the diagnostic dilemmas complex toxicology emergencies. We sought better understand confidence junior doctors in assessing managing toxicological emergencies across two departments Perth, Australia. Methods An online survey...
The burden of acute illicit drug use in Australia is largely unknown. Establishing a prospective surveillance system emergency departments using analytical confirmation may facilitate the early identification emerging drugs. We describe demographic data and toxicity patterns, stratified by drugs novel psychoactive substances, to Western Australia.Patients presenting with severe and/or unusual clinical features consistent recreational were identified across five Australian participating...
To determine the priorities for emergency medicine research of patients currently in an ED and to compare their with those ACEM researchers.A survey current EDs Royal Perth Hospital Armadale Health Service. Patients gave reason presentation, suggested three important ranked top 5 choices from a pre-specified list published by researchers. Results were analysed using qualitative quantitative methods.A total 430 completed survey, which 218 men (50.7%), median age 44 years (interquartile range...
Abstract Collaboration with consumers is an emerging focus for medical researchers worldwide. Public involvement increasingly encouraged, and in some cases stipulated by funding bodies, order to secure financial support. While consumer could be viewed as another hurdle the application process, it can add immense value research outcomes. However, given diverse transient nature of our group, how we develop meaningful public engagement emergency medicine research?