A5025398873- Hormonal and reproductive studies
- Pharmacological Effects and Assays
- Muscle metabolism and nutrition
- Analytical Chemistry and Chromatography
- Pharmacogenetics and Drug Metabolism
- Mass Spectrometry Techniques and Applications
- Estrogen and related hormone effects
- Forensic Toxicology and Drug Analysis
- Metabolomics and Mass Spectrometry Studies
- Pharmacology and Obesity Treatment
- Pesticide Residue Analysis and Safety
- Hormonal Regulation and Hypertension
- Erythrocyte Function and Pathophysiology
- Neurobiology and Insect Physiology Research
- Sexual Differentiation and Disorders
- Thyroid Disorders and Treatments
- Steroid Chemistry and Biochemistry
- Blood groups and transfusion
- Blood transfusion and management
- Antioxidant Activity and Oxidative Stress
- High Altitude and Hypoxia
- Effects and risks of endocrine disrupting chemicals
- Analytical Methods in Pharmaceuticals
- Alcohol Consumption and Health Effects
- Phytoestrogen effects and research
Federazione Medico Sportiva Italiana
2016-2025
Medica (Italy)
2016
King's College London
2010
Municipal Institute for Medical Research
1995-2004
Universitat Pompeu Fabra
2001-2004
Universitat Autònoma de Barcelona
1996-2002
A method for the toxicological screening of new designer drug methylenedioxypyrovalerone (MDPV) is described; with an emphasis on its application anti-doping analysis. The metabolism MDPV was evaluated in vitro using human liver microsomes and S9 cellular fractions CYP450 phase I uridine 5'-diphosphoglucuronosyltransferase (UGT) sulfotransferase (SULT) II studies. resulting metabolites were subsequently liquid/liquid extracted analyzed gas chromatography/mass spectrometry (GC/MS) as...
Abstract Sildenafil (SDF), vardenafil (VDF) and tadalafil (TDF) are phosphodiesterase type 5 enzyme inhibitors (PDE5Is), used in the treatment of erectile disorders to improve breathing efficiency pulmonary hypertension. The increasing incidence their use among young athletes has drawn attention anti‐doping authorities possible abuse PDE5Is by due pharmacological activities. This paper describes a method for determination urine metabolites gas chromatography/mass spectrometry (GC/MS) after...
We performed genotyping analysis of human biallelic polymorphisms (single nucleotide polymorphisms) for the detection homologous blood transfusion in sports doping. DNA was extracted from dried spots and quantified real-time fast PCR. The method proven to allow transfusions up a donor percentage 1%, with significant improvement terms sensitivity respect both reference cytofluorimetric previously proposed strategy based on STR-based strategy.
A fast and sensitive method for the comprehensive screening of anabolic agents other banned doping substances using gas chromatography/tandem mass spectrometry (GC/MS/MS) with an external ionization ion trap spectrometer is presented. The takes advantage resolving power MS/MS to eliminate background interferences, thus speeding up chromatographic analysis. For each compound, different fragmentation reactions were studied their collision energies optimized obtain best sensitivity in terms...
Rationale High‐resolution mass spectrometry (HRMS) has been demonstrated to be an alternative platform for quantitative analyses, identifying unknown compounds and gathering information the elucidation of chemical structures. This work describes a method detect 13 esters testosterone (T) 5 biomarkers in 0.1 mL human serum using gas chromatography (GC) coupled HRMS. Methods Analytes were extracted from after deproteinization liquid–liquid extraction. The trimethylsilyl derivatives analyzed...
Abstract Supercritical fluid chromatography‐mass spectrometry (SFC‐MS) has proved to be a beneficial tool for sample analysis wide variety of compounds and, as such, recently gained the attention anti‐doping community. We have tested applicability SFC‐MS routine doping control analysing approximately 3 × 1000 identical samples utilising instruments from three different vendors: Agilent Technologies, Waters Corporation and Shimadzu Corporation. A ‘dilute inject’ approach either without or...
Abstract This paper aims to study the metabolism of thyroid hormones (TH) in urine by liquid chromatography–tandem mass spectrometry (LC‐MS/MS). The method was applied samples collected before and after administration sodium triiodothyronine (T3) levothyroxine (T4) a euthyroid volunteer athletes declaring not supplementation. Samples were analyzed LC‐MS/MS enzymatic hydrolysis, liquid–liquid, solid‐phase extractions. Ratios between T3/thyronine T4/3,3′‐T2 may be used for detection exogenous...