The optimal duration of postsurgical antibiotic therapy for adult native joint bacterial arthritis remains unknown.We conducted a prospective, unblinded, randomised, non-inferiority study comparing either 2 or 4 weeks after surgical drainage in adults. Excluded were implant-related infections, episodes without lavage and with follow-up less than months.We enrolled 154 cases: 77 the 4-week arm 2-week arm. Median length intravenous treatment was 1 days, respectively. median number lavages both...

Objective: In countries where parasitic infections are endemic, autoimmune disease is relatively rare, leading to the hypothesis that parasite-derived immunomodulators may protect against its development. Consistent with this, we have previously demonstrated ES-62, a 62 kDa phosphorylcholine (PC)-containing glycoprotein secreted by filarial nematodes, can exert anti-inflammatory action in murine collagen-induced arthritis (CIA) model and human rheumatoid arthritis-derived synovial tissue...

Osteoarthritis (OA) is a degenerative joint disease with high prevalence among older people. To date, the pathogenesis of and link between muscle function OA not entirely understood. As there no known cure for OA, current research focuses on prevention symptomatic treatment disorder. Recent has indicated that weakness precedes onset symptoms. Furthermore, several studies show beneficial effect land-based aerobic strengthening exercises pain relief function. Therefore, possibility to employ...

We previously demonstrated inhibition of ovalbumin-induced allergic airway hyper-responsiveness in the mouse using ES-62, a phosphorylcholine-containing glycoprotein secreted by filarial nematode, Acanthocheilonema viteae. This correlated with ES-62-induced mast cell desensitisation, although degree to which this reflected direct targeting cells remained unclear as suppression Th2 phenotype inflammatory response, measured eosinophilia and IL-4 levels lungs, was also observed. now show that...

Fibrous dysplasia (FD) is a benign medullary fibro-osseous anomaly that compromises the mechanical strength of bones, especially long bones bear strong stresses. It can lead to an inability remodel immature bone into mature lamellar bone, resulting in inappropriate alignment response This case study describes rare polyostotic FD presenting with epiphyseal lesion proximal femoral head its weight-bearing zone, accompanied by unconventional malrotation. The present leads us recommend clinicians...

To the Editors: Over past 20 years, thanks to widespread use of nucleic acid amplification assays, number reported cases osteoarticular infection (OAI) due Kingella kingae (K. kingae) has increased markedly. Concepts about etiology OAIs have been reviewed and improved.1 These now highlight that K. must be considered one main pathogens responsible for hematogenous bones, joints intervertebral discs, especially among children between 6 48 months old.2–5 Rarer manifestations, such as...

Aims We aimed to describe the epidemiological, biological, and bacteriological characteristics of osteoarticular infections (OAIs) caused by Kingella kingae. Methods The medical charts all children presenting with OAIs our institution over a 13-year period (January 2007 December 2019) were reviewed. Among these patients, we extracted those which presented an OAI K. kingae their epidemiological data, biological results, aetiologies assessed. Results was main reported microorganism in...

Pediatric septic arthritis of the hip (SAH) in children is a severe pathology, requiring prompt diagnosis and treatment to avoid destructive sequelae joint. Its can be challenging, however, due its spectrum manifestations differential diagnosis. Last century, multiple research teams studied curves systemic inflammation markers aid Kocher showed that history fever >38.5 °C, non-weight bearing, an erythrocyte sedimentation rate >40 mm/h, serum white blood cells >12,000/mm3 were highly...

Human rhinoviruses (HRVs) are composed of 60 identical subunits, each comprising one copy the viral capsid proteins VP1, 2, 3, and 4. Consequently, symmetry-related epitopes available for binding antibodies or receptors. The minor receptor group HRVs uses members low-density lipoprotein family cell entry. ligand domains these receptors various numbers repeats, several modules within a single molecule believed to attach simultaneously star-shaped dome at 5-fold symmetry axis virus. Using...

Abstract We have previously shown that ES-62, a phosphorylcholine (PC)-containing glycoprotein secreted by the parasitic filarial nematode Acanthocheilonema viteae targets dendritic cell (DC) responses, specifically suppressing TLR4 signalling to inhibit Th1/Th17-driven inflammation. now investigated molecular mechanisms underpinning such immunomodulation and show here ES-62-mediated downregulation of protein kinase C-δ (PKC-δ), TLR4-associated mediator required for full activation...

Transphyseal hematogenous osteomyelitis (THO) is a serious condition that can affect the growing physis, yet it insufficiently recognized in children. The aim of this study was to explore prevalence and epidemiology pediatric THO, discuss underlying pathophysiology. All consecutive cases acute subacute admitted our institution over 17 years were retrospectively studied. Medical records examined for patient characteristics, bacteriological etiology, medical surgical management. Magnetic...

Introduction: Osteoarticular infections (OAIs) constitute serious paediatric conditions that may cause severe complications. Identifying the causative organism is one of mainstays care process, since its detection will confirm diagnosis, enable adjustments to antibiotic therapy and thus optimize outcomes. Two bacteria account for majority OAIs before 16 years age: Staphylococcus aureus known affecting older child, whereas Kingella kingae affects infants children younger than 4 old. We aimed...

BACKGROUND Femoral fracture is a significant major trauma in children and adolescents, sometimes resulting serious complications. This study aimed to determine the epidemiology of femoral fractures define associated injuries mortality incidence pediatric population below 16 years old. METHODS The medical records all patients with treated our hospital from 1997–2016 were reviewed retrospectively. Age, gender, mechanism trauma, month season occurrence, type, injuries, data collected. Patients...

Prevention of rotatory impairment and radial head dislocation in the forearm is an important aspect when treating children with osteochondromas. Various studies tried to determine best treatment, describing different surgical techniques. No consensus has been reached yet. This retrospective study compares treatment outcome patients osteochondroma radius ulna after or conservative treatment. Seventeen forearms treated over a period 20 years were analysed. Outcome parameters prospectively...

Intramedullary lengthening nails are an accepted alternative to external fixators but limited by anatomical preconditions. Therefore, date the use of is sometimes inevitable. We report on a new technique for correction combined limb length discrepancies and complex axis deformities using solely internal devices - nail locking plate.Between October 2008 November 2011 five patients (two femora, three tibias) with mean leg discrepancy 36 mm (25 50) angular deformity were treated fully...

Pyogenic tenosynovitis is an uncommon condition in children, and there are few published case reports. We present a series of 11 cases who were treated the Geneva Children Hospital last 10 years. Kingella kingae was main pathogen, characteristics infection (inflammatory indices, clinical findings severity) similar to other osteoarticular K. infections infants.

Ankle fracture is one of the most frequent pediatric lower-limb fractures and may result in serious complications.This study aimed to determine epidemiology ankle fractures, defining types, treatments, complications a population below 16 years old.Medical records all patients treated our hospital during 2004-2020 were retrospectively reviewed. Data regarding age, sex, mechanism injury, type, treatment modalities, collected.We examined involving 328 children with 331 ratio 1:2 male per...

Pediatric osteoarticular infections (OAIs) are serious conditions that can lead to severe septic complications, prolonged morbidity with long-term impaired function, and perturbed subsequent bone development. Kingella kingae (K. kingae) is currently accepted as the predominant pathogen in pediatric OAIs, especially among 6-48 month olds. The present study aimed identify clinical biological markers would refine detection of patients an OAI due K. kingae. We retrospectively studied every...