A5067484246- Metastasis and carcinoma case studies
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Colorectal Cancer Surgical Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lipid metabolism and biosynthesis
- Colorectal and Anal Carcinomas
- Photosynthetic Processes and Mechanisms
- Breast Cancer Treatment Studies
- Neuroendocrine Tumor Research Advances
- Retinoids in leukemia and cellular processes
- Luminescence and Fluorescent Materials
- Radiomics and Machine Learning in Medical Imaging
- Anorectal Disease Treatments and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastrointestinal Tumor Research and Treatment
- Diverticular Disease and Complications
- Metal complexes synthesis and properties
- Metabolomics and Mass Spectrometry Studies
- Lung Cancer Research Studies
- Cancer therapeutics and mechanisms
- Congenital Anomalies and Fetal Surgery
- Gastrointestinal disorders and treatments
- Cancer and Skin Lesions
- Helicobacter pylori-related gastroenterology studies
Nagoya University
2020-2022
Sasebo City General Hospital
1989-2016
Kitakyushu City Hospital Organization
1998
Harvard University
1997
Massachusetts Eye and Ear Infirmary
1997
City Hospital
1994
Nagasaki University
1983-1991
University of Wisconsin–Madison
1977
Hiratsuka City Hospital
1974
It has been widely suggested that histones, the basic proteins of nucleus, are integral units mammalian chromosomes and they assist in regulation genetic expression.'-3 If so, metabolism these might be expected to show a specific temporal relationship replication chromosomal DNA. In present study, synchronized cultures HeLa cells have used look for such relationship. For this purpose three types experiments were carried out: (1) Direct labeling studies, which activities isolated nuclear...
Abstract Metabolic distribution of fatty acid to organelles is an essential biological process for energy homeostasis as well the maintenance membrane integrity, and metabolic pathways are strictly regulated in response environmental stimuli. Herein, we report a fluorescent probe, which bears azapyrene dye that changes its absorption emission features depending on microenvironment polarity organelle into it transported. Owing sensitivity this dye, metabolically incorporated probe non-polar...
Super-resolution imaging techniques have become increasingly important tools to visualize suborganelle structures and dynamic processes in living cells on the nanoscale. However, utility of these is currently limited by availability advanced fluorescent probes that enable specific labeling organelle interest provide absorption/emission properties required for super-resolution techniques. Herein, LysoPB Yellow presented as a new small-molecule probe can selectivity stain lysosomal membrane....
Lipid droplets (LDs) are essential organelles in most eukaryotes, and tracking intracellular LD dynamics using synthetic small molecules is crucial for biological studies. However, only a limited number of fluorescent markers that satisfy all requirements, such as the selective staining LDs, high photostability, sufficient biocompatibility, have been developed. Herein, we report series donor-π-acceptor dyes based on thiophene-containing fused polycyclic scaffold...
Adipocyte-rich omentum offers "good soil" for disseminating ovarian cancer (OvCa), contributing to therapeutic difficulty. However, little is understood about the association between adipocytes and tumor growth at peritoneal dissemination site. Herein, we report induction of adipocyte dedifferentiation by OvCa cells pro-tumorigenic effects resulted adipocyte-derived fibroblasts. We confirmed that malignant ascites promoted primary human obtained from surgical omental specimen into fibroblast...
A series of phosphine oxide-bridged rhodamines (P-rhodamines) bearing various acyclic and cyclic amine moieties, including dimethyl- diethylamine, azetidine, pyrrolidine 7-azabicyclo[2,2,1]heptane (7ABH), have been synthesized. The photophysical properties as well chemical photostability these dyes studied in detail. Among dyes, the 7ABH-substituted dye shows stronger fluorescence near-infrared (NIR) region, relative to other P-rhodamines. This could be applied live-cell imaging, wherein...
We studied obstructing colorectal cancer by comparing with those without obstruction to elucidate the long-term prognosis. Subject were 357 patients including 79 (21.1%) who manifested ileus symptoms initially (obstructed group) and another 278 (79.9%) (not obstructed group). In this study, we designated as developed abdominal pain, vomiting, distention, had air-fluid level formation in an simple X-ray film on standing position, needed some decompression treatment. The group was comprized of...
大腸癌の発育過程を知る目的で, 手術摘出標本にmicroangiographyを行い, 大腸ポリープと癌の血管構築像を形態別に分類して検討した.大腸ポリープの血管構築は基本的に樹枝状, 扇状, 柵状, 混合型に分類され, 腫瘍の異型性に準じた改築がみられた.有茎性ポリープは樹枝状, 扇状を呈し, 柵状型はIIa, IIa+IIc, 混合型はIIa集籏型であった.癌化率は対全病変20%で, 腫瘍径に比例して高くなる傾向がみられた.腫瘤型pm癌はポリープの樹枝状, 扇状型に類似し, stalk invasionの像がみられた. ss (a1) 以深では血管系の改築に伴う微小循環樟害性病変がみられ, 潰瘍型の頻度が高い.潰瘍型進行癌は柵状型からの水平方向進展と樹枝状, 扇状型からの垂直方向進展が推察され, 後者は約65%にみられた.大腸ポリープの血管構築の特性とその改築様式は腫瘍の増殖に対応して大腸癌の発育, 進展に大きく関与することを強調した.
Lipid droplets (LDs) are essential organelle in most eukaryotes, and tracking intracellular LDs dynamics using synthetic small molecules is crucial for biological studies. However, only a limited number of fluorescent markers that satisfy all requirements, such as the selective staining LDs, high photostability, sufficient biocompatibility, have been developed. Herein, we report series donor-p-acceptor dyes based on thiophene-containing fused polycyclic scaffold [1]benzothieno[3,2- b...
症例は66歳の女性で，突然の上腹部痛，嘔気を主訴として受診した．初診時腹部単純CTで胃拡張症と診断し，内科入院で保存的加療を行った．症状の改善乏しく，CT再検して脾臓が胃の背側へ遊走して，胃前庭部が左上腹部に捻転して押し上げられていた．上部消化管造影検査でも幽門部が高位に存在しており，遊走脾に伴う胃軸捻転症の診断となった．内視鏡的整復を試みたが困難であり，手術目的に当科紹介となった．胃短軸捻転症で胃体部後壁に壊死による穿孔を認め，胃軸捻転解除術，胃腹壁固定術，大網被覆術を施行した．術後経過は良好で胃潰瘍もほぼ改善し，第13病日で退院した．胃軸捻転症はまれな疾患であるが，胃拡張を呈した急性腹症の診断の際には念頭に置くべき疾患であると考えられた．
34例の同時性大腸多発癌について臨床病理学的検討を行い, さらにnow cytometerを用いて核DNA量を測定し以下の結果を得た.多発癌の占居部位では34例中15例 (44%) で同一領域内に発生しており, 特にS状結腸に多発していた.多発癌の第2癌は第1癌に比べ肉眼型で0型, 壁深達度で粘膜癌, 粘膜下層癌, 組織型で高分化腺癌が多かった.予後は単発癌の5年生存率が68%に対し, 多発癌では75%であった.核DNA量を測定した14症例37病変中, DNA diploidyは27例, aneuploidyは10例であったが, ploidypatternと肉眼型, 組織型, 壁深達度の間には有意差を認めなかった.各症例におけるDNA ploidypattemの組合せは, diploidyどうしが7例, diploidyとDNA aneuploidyが4例, DNAaneuploidyどうしが3例であり, aneuploidyどうしの組み合せでは, そのDI値は異なっており, 同時性大腸多発癌の各病変が独立した起源であることが示唆された.
Thirteen cases of breast phyllodes tumor have been experienced and 3 them had local recurrence. Seventeen surgical samples obtained from these 13 including recurred ones were studied in terms correlations between recurrence histologic appearance or DNA ploidy, to determine if this analysis would help predict the clinical behavior.As appearance, all occurred after treatment with excisional procedure histologically benign tumors. For that reason, when evaluation was limited disease treated...
Lipid droplets (LDs) are essential organelle in most eukaryotes, and tracking intracellular LDs dynamics using synthetic small molecules is crucial for biological studies. However, only a limited number of fluorescent markers that satisfy all requirements, such as the selective staining LDs, high photostability, sufficient biocompatibility, have been developed. Herein, we report series donor-p-acceptor dyes based on thiophene-containing fused polycyclic scaffold...