Previous reports on thelaziasis from the Republic of Korea focused parasite identification and zoonotic infections in humans. This retrospective study aimed to characterize clinical patterns pet dogs. To describe characteristics canine ocular small animal settings Korea. Medical records 35 dogs (44 eyes), diagnosed with at Dr. Park's Animal Eye Clinic between March 2022 February 2024, were retrospectively reviewed. Nine had bilateral infections, while 26 unilateral infections. Most cases...

Abstract Severe fever with thrombocytopenia syndrome (SFTS) virus is an emerging zoonotic in East Asia. However, SFTS (SFTSV) has not been reported to cause clinical infection companion dogs date. We report the case of a 4‐year‐old dog that presented fever, vomiting, leukocytopenia and at veterinary hospital Republic Korea. It was diagnosed SFTS, which confirmed using real‐time reverse transcription PCR, sequencing indirect immunofluorescence assay, recovered after supportive care. Further...

Diarrhea is one of the most common clinical symptoms in cats and can be caused by infectious pathogens investigation prevalence, co-infection seasonality enteropathogens are not well-established diarrheic cats.Fecal samples 1620 were collected detected using real-time PCR. We retrospectively investigated features, total/seasonal infection patterns enteropathogens. The positive rate was 82.59%. Bacterial, viral, protozoal infections accounted for 49.3, 37.57, 13.13% cases, respectively....

Background Mesenchymal stem/stromal cells (MSCs) are effective therapeutic agents that ameliorate inflammation through paracrine effect; in this regard, extracellular vesicles (EVs) have been frequently studied. To improve the secretion of anti-inflammatory factors from MSCs, preconditioning with hypoxia or hypoxia-mimetic has attempted and molecular changes preconditioned MSC-derived EVs explored. In study, we aimed to investigate increase hypoxia-inducible factor 1-alpha...

Limb-sparing surgery is one of the surgical options for dogs with distal radial osteosarcoma (OSA). This case report highlights novel application a three-dimensional (3D)-printed patient-specific polycaprolactone/β-tricalcium phosphate (PCL/β-TCP) scaffold in limb-sparing dog OSA. The outcomes evaluated included postoperative gait analysis, complications, local recurrence tumor, metastasis, and survival time. Post-operative evaluation showed significant improvement limb function, including...

Abstract Tumor-associated macrophages (TAMs) play an important role in the tumor microenvironment by producing cytokines and growth factors. Furthermore, TAMs multifunctional roles progression, immune regulation, metastasis, angiogenesis, chemoresistance. Hypoxia induces tumor-supporting transformation of TAMs, which enhances malignancy through developing anti-cancer resistance, for example. In this study, a hybrid spheroid model canine mammary gland (MGT) cell lines (CIPp CIPm) (DH82) was...

Salivary alpha-amylase (sAA) is a stress biomarker in human diseases, but there are no reports of sAA measurements diseased dogs. This study measured the and serum (AA) levels 16 healthy dogs 31 using kinetic enzyme assay to assess status. The AA were significantly higher than (p < 0.05), was correlation between 2 groups (r = 0.251, p 0.089). suggests that can be useful as

Abstract Background Tracheal collapse (TC), a common disease in dogs, is characterized by cough; however, little known about the serum biomarkers that can objectively evaluate severity of cough canine TC. Furthermore, studies elucidating relationship fluoroscopic characteristics with are lacking. Therefore, this study aimed to between and clinical characteristics, images, new Results Fifty-one client-owned dogs diagnosed TC based on signs were enrolled divided into three groups according...

Abstract Background Sodium‐glucose cotransporter‐2 (SGLT2) inhibitors are a novel class of anti‐hyperglycaemic agents. Objective This study aimed to evaluate the safety and adjuvant glycaemic control effect an SGLT2 inhibitor, DWP16001, in diabetic dogs receiving insulin treatment. Methods Nineteen treatment (NPH, porcine lente glargine insulin) were divided into two groups according dosing frequency: DWP TOD group ( n = 10) SID 9). In group, 0.025 mg/kg DWP16001 was administered once every...

Abstract Background Romiplostim, a thrombopoietin analog, is commonly used to treat immune‐mediated thrombocytopenia (ITP) in humans, but its use dogs remains limited. Objectives Evaluate the effects and adverse events of romiplostim administration with caused by various underlying diseases. Animals Forty‐two client‐owned naturally occurring at 2 referral animal hospitals. Methods Retrospective, multi‐institutional analysis evaluate outcomes treatment dogs. Results Among treated romiplostim,...

Objectives As bacterial infection can lead to sepsis and high mortality, early easy diagnosis of improve survival. In cats, the systemic is quite challenging, and, usually, non-specific markers for inflammation are employed. humans, procalcitonin, heparin-binding protein absolute neutrophil count biomarkers that studied in infections owing their sensitivity specificity. Methods A total 56 cats were categorised into 16 healthy 40 bacterially infected diagnosed by various examinations. all...

Abstract Background The use of salivary biomarkers has garnered attention because the composition saliva reflects body’s physiological state. Saliva contains a wide range components, including peptides, nucleic acids, electrolytes, enzymes, and hormones. It been reported that alpha-amylase cortisol are stress related biomarker in diseased dogs; however, evaluation pre- post- operation not studied yet. aim this study was to evaluate levels dogs before after they underwent surgery investigate...

Abstract Background As a co-receptor for fibroblast growth factor 23, klotho plays pivotal role in phosphate metabolism. The kidney is known to be the main source of soluble alpha-klotho and principal regulator its concentration. Previous studies human participants showed that concentration serum urine decreased chronic disease (CKD) patients. However, no previous study has assessed levels dogs. This aimed measure urinary CKD dogs identify their associations with International Renal Interest...

Background Preconditioning with lipopolysaccharide (LPS) is used to improve the secretion of anti-inflammatory agents in B cells. However, there are only a few studies on canine Objective This study aimed evaluate immune regulatory capacity peripheral blood mononuclear cell-derived cells pretreated LPS. Methods Canine were isolated from cells, which obtained three healthy donors. The preconditioned LPS, and then cell viability expression marker assessed. Finally, RNA extraction...

Diagnosis of acute pancreatitis in dogs remains a significant challenge despite the development advanced diagnostic methodologies.Visual inspection and pancreas biopsy using laparoscopy are generally considered to be procedures free complications when conducted on healthy animals.However, usefulness for diagnosing has not been assessed.In present study, efficacy was evaluated animals with experimentally induced pancreatitis.Gross appearance pancreatic area examined by survey presence edema,...

Abstract Background An accurate and easily accessible method for diagnosing malignancies in local veterinary clinics has not yet been established. Objectives To investigate the usefulness of serum thymidine kinase 1 (TK1) protein its autoantibody as tumor biomarkers dogs. Animals Serum samples from 1702 dogs were collected animal hospitals referral medical centers South Korea. Methods TK1 OD value ratio (TK1 OD/total IgG OD) classified into healthy controls, group with nontumor disease,...

6021 Background: To evaluate the effectiveness of topically applied human recombinant epidermal growth factor (rhEGF) in reduction oral mucositis induced by radiotherapy (or concurrent chemoradiotherapy) patients with head and neck cancer. Methods: Patients cancer receiving external (RT) to cavity or soft palate conventional fractionation (2 Gy/fraction, 5 fractions weekly, minimum 25 fractions) were entered into a study. assigned placebo group one three EGF-treatment groups (10 μg/ml, 50...

We performed this study to characterize the difference between inflammatory and non-inflammatory status in diseased dogs by measuring salivary C-reactive protein (CRP) levels. In addition, we assessed whether a correlation exists CRP levels saliva those serum. were measured 32 client-owned dogs, which then divided into inflammation non-inflammation groups based on serum level. The level was higher group than (p &lt; 0.05). Furthermore, there positive (R = 0.866, p 0.001). These data suggest...

Abstract Objective The aim of this report is to document the case a dog that developed pleural effusion as potential side‐effect administration high‐dose amlodipine. Case summary A Yorkshire terrier (13‐year‐old, castrated male, 4.5 kg) presented with severe systemic hypertension (&gt;200 mmHg), hyperkalaemia, and acute pancreatitis. had hyperadrenocorticism, chronic valvular heart disease, kidney cerebellar infarction underlying diseases. Additionally, laboured breathing tachypnoea during...

Abstract Background In humans, several safety evaluations have shown minimal adverse events with oral paclitaxel; however, its therapeutic efficacy and has not been well established in dogs various cancers. Objectives We aimed to retrospectively evaluate the of paclitaxel Methods Twenty‐one diagnosed cancers were administered doses three times a month (group 1) or six 2). Results The overall response rate was 6.25% (6.25%, complete response; 56.25%, stable disease; 37.5%, progressive...

Abstract Background Canine mammary gland cancer (CMGC) is a common neoplasm in intact bitches. However, the benefit of adjuvant chemotherapy unclear. The aim this study was to investigate anti-proliferative effects paclitaxel on CMGC in-vitro and in-vivo settings. Results Paclitaxel dose-dependently inhibited viability induced G2/M phase cell cycle arrest apoptosis both primary metastatic lines (CIPp CIPm). In animal experiments, average tumour volume decreased significantly proportion...