A5073833206- Mangiferin and Mango Extracts
- Fatty Acid Research and Health
- Medicinal Plant Research
- Hormonal Regulation and Hypertension
- Cardiac Fibrosis and Remodeling
- Diet and metabolism studies
- Free Radicals and Antioxidants
- Nitric Oxide and Endothelin Effects
- Macrophage Migration Inhibitory Factor
- Cancer, Hypoxia, and Metabolism
- Medicinal Plants and Bioactive Compounds
- Cancer-related Molecular Pathways
- HIV-related health complications and treatments
- Natural Compound Pharmacology Studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Agricultural and Biological Research
- Cancer Research and Treatments
University of Indonesia
2015-2023
Osaka University
2020-2022
The resolution of inflammation is closely linked with tissue repair. Recent studies have revealed that macrophages suppress inflammatory reactions by producing lipid mediators, called specialized proresolving mediators (SPMs); however, the biological significance SPMs in repair remains to be fully elucidated heart. In this study, we focused on maresin-1 (MaR1) and examined reparative effects MaR1 cardiomyocytes. treatment increased cell size cultured neonatal rat Since expression fetal...
Abstract Tumor suppressor protein p53 plays crucial roles in the onset of heart failure. activation results cardiac dysfunction, at least partially by suppressing angiogenesis. Though has been reported to reduce VEGF production inhibiting hypoxia‐inducible factor, anti‐angiogenic property remains be fully elucidated cardiomyocytes. To explore molecular signals downstream that regulate vascular function, especially under normoxic conditions, DNA microarray was performed using...
Treatment of iron overload in thalassaemia is still a great burden for patients, their families and the health care system developing countries like Indonesia, because expensiveness unwanted side effects chemical iron-chelating therapeutics. This animal study investigates an extract from leaves Mangifera foedica L (EMF) its major active compound, mangiferin, chelating antioxidant treatment overload. Sixty rats were randomly divided into 10 groups: control, (IO), IO with mangiferin doses...
Introduction: Thalassemia is a hereditary anemia usually treated with regular blood transfusions, which can result in elevated levels of total iron the body. As soon as capacity iron-regulating proteins (e.g., ferritin, transferrin) are used up, free plasma increases generating reactive oxygen species (ROS), leading to oxidative stress. Hence, transfusions should be accompanied by iron-chelating therapy, e.g., deferiprone (DFP). The purpose this study was evaluate effect mangiferin (M) and...
Ethanolic extract of bacang mango leaves ( Mangifera foetida L.) decreased iron concentration in blood Sprague dawley rats that had been induced overload. The aimed this experiment was to determine acute toxicity (LD 50 ) value ethanolic M.foetida by weil method and its effect component. This study conducted employing a complete random design using 25 male female mice DDY strain which devided into 5 groups. first group until fourth were administered M .foetida with dose variation suspension...
Myocardial inflammation is a critical event for the onset and progression of heart failure. Maresin 1 (MaR1) was originally identified as macrophage lipid mediator that exhibits anti-inflammatory pro-resolving activities. Though it widely accepted macrophages positively negatively regulate myocardial through cytokines growth factors, biological functions mediators, such MaR1, in cardiomyocytes remain to be addressed. This study explored functional roles MaR1 cardiomyocytes. Neonatal rat...
Dragon fruit, known as Hylocereus undantus (HU), has traditionally been utilized in Banyuwangi, East Java, Indonesia, for addressing gout and rheumatism. Despite its empirical use, there is a lack of reported pharmacological research on this plant. This study aimed to explore the properties HU extract treating hyperuricemia, inflammation, pain. Adenine-potassium oxonate-induced mice were employed evaluate anti-hyperuricemia activity, measuring uric acid, blood urea nitrogen (BUN), creatinine...
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