A5053027227- Protein Structure and Dynamics
- DNA and Nucleic Acid Chemistry
- Advanced NMR Techniques and Applications
- Enzyme Structure and Function
- Molecular spectroscopy and chirality
- RNA and protein synthesis mechanisms
- NMR spectroscopy and applications
- Electron Spin Resonance Studies
- Spectroscopy and Quantum Chemical Studies
- Photochemistry and Electron Transfer Studies
- Bacterial Genetics and Biotechnology
- Photoreceptor and optogenetics research
- Mass Spectrometry Techniques and Applications
- Glycosylation and Glycoproteins Research
- Estrogen and related hormone effects
- Solid-state spectroscopy and crystallography
- Photosynthetic Processes and Mechanisms
- Advanced Chemical Physics Studies
- Photochromic and Fluorescence Chemistry
- Metabolomics and Mass Spectrometry Studies
- Analytical Chemistry and Chromatography
- Bacteriophages and microbial interactions
- Genomics and Chromatin Dynamics
- Lipid Membrane Structure and Behavior
- Chemical Reaction Mechanisms
Utrecht University
2009-2023
Novosibirsk State University
2012-2013
International Tomography Center
2012-2013
University of Amsterdam
1979-2007
Universidade de São Paulo
2006
University of the Western Cape
2006
University of Wisconsin–Madison
2004
Rutgers, The State University of New Jersey
1990-2004
Rutgers Sexual and Reproductive Health and Rights
1996-2004
Ludwig-Maximilians-Universität München
1993-2003
The three-dimensional structure of the DNA-binding domain (DBD) glucocorticoid receptor has been determined by nuclear magnetic resonance spectroscopy and distance geometry. a 71-residue protein fragment containing two "zinc finger" domains is based on large set proton-proton distances derived from Overhauser enhancement spectra, hydrogen bonds in previously identified secondary elements, coordination zinc atoms conserved cysteine residues. DBD found to consist globular body which finger...
Interaction of regulatory DNA binding proteins with their target sites is usually preceded by to nonspecific DNA. This speeds up the search for site several orders magnitude. We report solution structure and dynamics complex a dimeric lac repressor domain The same set residues can switch roles from purely electrostatic interaction backbone in highly specific mode base pairs cognate operator sequence. protein-DNA interface flexible on biologically relevant time scales that may assist rapid...
Abstract
R. Kaptein, J. Chem. Soc. D, 1971, 732 DOI: 10.1039/C29710000732
Abstract State‐of‐the‐art methods based on CNS and CYANA were used to recalculate the nuclear magnetic resonance (NMR) solution structures of 500+ proteins for which coordinates NMR restraints are available from Protein Data Bank. Curated obtained BioMagResBank FRED database. Although original determined by various methods, they all recalculated refined subsequently restrained molecular dynamics (CNS) in a hydrated environment. We present an extensive analysis results, terms quality...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSequential resonance assignments in proton NMR spectra of oligonucleotides by two-dimensional spectroscopyR. M. Scheek, R. Boelens, N. Russo, J. H. Van Boom, and KapteinCite this: Biochemistry 1984, 23, 7, 1371–1376Publication Date (Print):March 27, 1984Publication History Published online1 May 2002Published inissue 27 March 1984https://pubs.acs.org/doi/10.1021/bi00302a006https://doi.org/10.1021/bi00302a006research-articleACS PublicationsRequest...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemically induced dynamic nuclear polarization. VIII. Spin dynamics and diffusion of radical pairsR. KapteinCite this: J. Am. Chem. Soc. 1972, 94, 18, 6251–6262Publication Date (Print):September 1, 1972Publication History Published online1 May 2002Published inissue 1 September 1972https://pubs.acs.org/doi/10.1021/ja00773a001https://doi.org/10.1021/ja00773a001research-articleACS PublicationsRequest reuse permissionsArticle...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSequential resonance assignments in DNA proton NMR spectra by two-dimensional NOE spectroscopyR. M. Scheek, N. Russo, R. Boelens, Kaptein, and J. H. Van BoomCite this: Am. Chem. Soc. 1983, 105, 9, 2914–2916Publication Date (Print):May 1, 1983Publication History Published online1 May 2002Published inissue 1 1983https://pubs.acs.org/doi/10.1021/ja00347a075https://doi.org/10.1021/ja00347a075research-articleACS PublicationsRequest reuse...
An analysis is given of the field dependence CIDNP generated in reactions flexible polymethylene biradicals. Nuclear polarization calculated by a stochastic Liouville method, which dynamics chains incorporated. Two dynamical models have been considered: RIS (rotational isomeric state) model can only be used for with up to seven segments, and RD (restricted diffusion) developed larger chains. The describes relative motion biradical ends as diffusion-like motion, related end-to-end distance...
Various hyperpolarization methods are able to enhance the sensitivity of nuclear magnetic resonance (NMR) spectroscopy and imaging (MRI) by several orders magnitude. Among these para-hydrogen-induced polarization (PHIP) signal amplification reversible exchange (SABRE), which exploit strong alignment para-hydrogen. Several SABRE experiments have been reported but, so far, it has not possible account for experimentally observed sign magnetic-field dependence substrate polarization. Herein, we...
The recommendations presented here are designed to support easier communication of NMR data and structures proteins nucleic acids through unified nomenclature reporting standards. Much this document pertains the in journal articles; however, interest future development structural biology, it is desirable that bulk reported information be stored computer‐accessible form freely accessible scientific community standardized formats for exchange. These stem from an IUPAC‐IUBMB‐IUPAB inter‐union...