A5023759829- Axial and Atropisomeric Chirality Synthesis
- Alkaloids: synthesis and pharmacology
- Chemical synthesis and alkaloids
- Catalytic C–H Functionalization Methods
- Synthesis of Indole Derivatives
- Enzyme Catalysis and Immobilization
- Plant biochemistry and biosynthesis
- Chemical Synthesis and Reactions
- Natural product bioactivities and synthesis
- Chromatography in Natural Products
- Essential Oils and Antimicrobial Activity
- Microbial Natural Products and Biosynthesis
- Carbohydrate Chemistry and Synthesis
University of Michigan
2021-2022
Florida Gulf Coast University
2016-2017
The discovery of the (+)-α-thujone and (−)-β-thujone stereoisomers in essential oil sage (Salvia officinalis L.) dietary supplements is documented for first time. detection was accomplished using a chiral resolution protocol racemic α-/β-thujone on headspace solid-phase microextraction–gas chromatography–mass spectrometry. Because previously unreported stereoisomers, (−)-β-thujone, are not commercially available, three-step synthesis thujone from available starting materials developed....
Despite their varied purposes, many indispensable molecules in medicine, materials, and asymmetric catalysis share a biaryl core. The necessity of joining arene building blocks to access these valuable compounds has inspired multiple approaches for bond formation challenged chemists develop increasingly concise robust methods this task. Oxidative coupling two C–H bonds offers an efficient strategy the C–C bond, however, fundamental challenges remain controlling reactivity selectivity uniting...
Biocatalysis offers compelling advantages in synthesis, often becoming the method of choice based on sustainability, safety, and selectivity considerations. Despite these advantages, enzymes synthesis are typically dedicated to functional group interconversions linear synthetic sequences have not been broadly integrated into retrosynthetic logic for carbon skeleton assembly. In this article, we disclose a biocatalytic platform fragment coupling assemble target molecules convergently....
Despite their varied purposes, many indispensable molecules in medicine, materials, and asymmetric catalysis share a biaryl core. The necessity of joining arene building blocks to access these valuable compounds has inspired multiple approaches for bond formation challenged chemists develop increasingly concise robust methods this task. Oxidative coupling two C–H bonds offers an efficient strategy the C–C bond, however, fundamental challenges remain controlling reactivity selectivity uniting...
Biocatalysis offers compelling advantages in synthesis, often becoming the method of choice based on sustainability, safety, and selectivity considerations. Despite these advantages, enzymes synthesis are typically dedicated to functional group interconversions linear synthetic sequences have not been broadly integrated into retrosynthetic logic for carbon skeleton assembly. In this article, we disclose a biocatalytic platform fragment coupling assemble target molecules convergently....