About
Contact & Profiles
A5072895131
Research Areas
- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- RNA and protein synthesis mechanisms
- Crystallography and molecular interactions
- Crystallization and Solubility Studies
- Click Chemistry and Applications
- Synthesis and Biological Evaluation
- CRISPR and Genetic Engineering
- X-ray Diffraction in Crystallography
- Mitochondrial Function and Pathology
University of Montana
2015-2022
Center for Environmental Health
2018
The c-MYC oncogene mediates multiple tumor cell survival pathways and is dysregulated or overexpressed in the majority of human cancers. NHE III1 region promoter forms a DNA quadruplex. Stabilization this structure with small molecules has been shown to reduce expression c-MYC, targeting quadruplex become an emerging strategy for development antitumor compounds. Previous solution NMR studies have assigned major conformer topology important target, however, regions outside G-quartet core were...
10.1371/journal.pone.0205584
article
EN
cc-by
PLoS ONE
2018-10-12
10.1016/j.bmcl.2015.02.063
article
EN
Bioorganic & Medicinal Chemistry Letters
2015-03-03
10.1016/j.bmc.2020.115781
article
EN
Bioorganic & Medicinal Chemistry
2020-09-24
10.1016/j.bmc.2022.116911
article
EN
Bioorganic & Medicinal Chemistry
2022-07-01
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