A5081141288- RNA Research and Splicing
- Adipose Tissue and Metabolism
- Cardiovascular and exercise physiology
- Ubiquitin and proteasome pathways
- Protein Tyrosine Phosphatases
- Genomics and Chromatin Dynamics
- Muscle Physiology and Disorders
- Exercise and Physiological Responses
- Galectins and Cancer Biology
- Peroxisome Proliferator-Activated Receptors
University of Basel
2020-2022
Universität Ulm
2018
Noonan syndrome (NS), the most common RASopathy, is caused by mutations affecting signaling through RAS and MAPK cascade. Recently, genome scanning has discovered novel genes implicated in NS, whose function RAS-MAPK remains obscure, suggesting existence of unrecognized circuits contributing to signal modulation this pathway. Among these genes, leucine zipper-like transcriptional regulator 1 (LZTR1) encodes a functionally poorly characterized member BTB/POZ protein superfamily. Two classes...
Regular physical activity induces a variety of health benefits, preventing and counteracting diseases caused by sedentary lifestyle. However, the molecular underpinnings skeletal muscle plasticity in exercise remain poorly understood. We identified role Krüppel-Like Factor 5 (Klf5) this process, particular regulation lipid homeostasis. Surprisingly, gain- loss-of-function studies vivo revealed seemingly opposite functions Klf5 response to an acute bout chronic training, modulating oxidation...
Abstract Background Interventions to preserve functional capacities at advanced age are becoming increasingly important. So far, exercise provides the only means counteract age‐related decrements in physical performance and muscle function. Unfortunately, effectiveness of interventions elderly populations is hampered by reduced acceptance compliance as well disuse complications. We therefore studied whether application interleukin‐6 (IL‐6), a pleiotropic myokine that induced skeletal...
Significance The function of tissues is controlled by complex biological processes, in which transcriptional mechanisms play a fundamental role. coactivator PGC-1α prototypical regulator adaptive responses evoked environmental and internal cues (e.g. exercise-adaptation skeletal muscle). Here, we found that PGC-1α-RNA–binding central to assemble multiprotein complexes controlling gene transcription. Interestingly, also regulates chromatin recruitment transcriptionally active liquid-like...
Abstract The peroxisome-proliferator-activated receptor-γ coactivator-1α (PGC-1α) integrates environmental cues by controlling complex transcriptional networks in various metabolically active tissues. However, it is unclear how a coregulator coordinates dynamic biological programs response to multifaceted stimuli such as endurance training or fasting. Here, we discovered central function of the poorly understood C-terminal domain (CTD) PGC-1α bind RNAs and assemble multi-protein complexes....