A5074712156- Vitamin C and Antioxidants Research
- Physiological and biochemical adaptations
- Aquaculture Nutrition and Growth
- Aldose Reductase and Taurine
- Reproductive biology and impacts on aquatic species
- Vitamin K Research Studies
- Genetics and Physical Performance
- Anesthesia and Neurotoxicity Research
- Cholinesterase and Neurodegenerative Diseases
- Selenium in Biological Systems
- Biochemical effects in animals
- Trace Elements in Health
- Cardiac electrophysiology and arrhythmias
- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- Ion channel regulation and function
- Nitric Oxide and Endothelin Effects
- Alzheimer's disease research and treatments
- Amino Acid Enzymes and Metabolism
- Antioxidant Activity and Oxidative Stress
- Genetics and Neurodevelopmental Disorders
- Coenzyme Q10 studies and effects
Western University
1990-2014
Abstract Stanniocalcin (STC) is a glycoprotein hormone first identified in bony fishes where it counteracts hypercalcemia by inhibiting gill calcium uptake and stimulating renal inorganic phosphate (Pi) reabsorption. Human STC (hSTC) has recently been cloned sequenced highly homologous to the fish at amino acid level. The objective of this study was examine possible effects hSTC on electrolyte homeostasis function rat. Recombinant expressed bacteria purified metal-ion affinity chromatography...
Stanniocalcin (STC) is a homodimeric glycoprotein hormone that was first discovered in fish, where it produced by unique endocrine glands known as the corpuscles of Stannius (CS). In freshwater salmon, STC plays an integral role Ca 2+ and phosphate homeostasis. High levels extracellular promote synthesis release STC, which on entering bloodstream reduces gill gut transport renal excretion to restore normocalcemia. this report, we have examined seawater salmon. We studied distribution protein...
Sodium-coupled, high-affinity choline transporters (CHTs) are inhibited by 3-morpholinosydnonimine (SIN-1) [peroxynitrite (ONOO − ) donor]; ONOO can be produced from nitric oxide and reactive oxygen species during neurodegeneration. SIN-1 rapidly increases CHT internalization the cell surface, this correlates with decreased uptake. This study addresses mechanisms which inhibits function in human neuronal SH-SY5Y cells. Thus, mutant L531A-CHT, does not constitutively internalize into cells a...
Abstract Ascorbate (reduced vitamin C) is required for bone formation. We have shown previously that both the osteoblast-like cell line ROS 17/2.8 and primary cultures of rat calvarial cells possess a saturable, Na+-dependent uptake system L-ascorbate (J Membr Biol 111:83–91, 1989). The purpose present study was to investigate specificity this transport organic anions its sensitivity inhibitors. Initial rates ascorbate were measured by incubating with [L-14C]ascorbate at 37°C. Uptake (5 μM)...