A5019078193- Microbial Community Ecology and Physiology
- Bacterial biofilms and quorum sensing
- Vibrio bacteria research studies
- Methane Hydrates and Related Phenomena
- Genomics and Phylogenetic Studies
- Aquaculture disease management and microbiota
- Bacterial Genetics and Biotechnology
- Cell Image Analysis Techniques
University of Basel
2021-2023
Max Planck Institute for Terrestrial Microbiology
2021-2023
Philipps University of Marburg
2021-2023
Abstract Bacteria often grow into matrix‐encased three‐dimensional (3D) biofilm communities, which can be imaged at cellular resolution using confocal microscopy. From these 3D images, measurements of single‐cell properties with high spatiotemporal are required to investigate heterogeneity and dynamical processes inside biofilms. However, the rely on automated segmentation bacterial cells in is a technical challenge. To improve accuracy biofilms, we first evaluated recent classical deep...
This work demonstrates that the Vibrio cholerae type six secretion system (T6SS) can actively kill prey strains within interior of biofilm populations with substantial impact on population dynamics. We additionally show response regulator VxrB contributes to both T6SS killing and protection from biofilms.
Bacterial biofilms are among the most abundant multicellular structures on Earth and play essential roles in a wide range of ecological, medical, industrial processes. However, general principles that govern emergence biofilm architecture across different species remain unknown. Here, we combine experiments, simulations, statistical analysis to identify shared biophysical mechanisms determine early development at single-cell level, for Vibrio cholerae, Escherichia coli, Salmonella enterica,...
Abstract Bacterial biofilms are among the most abundant multicellular structures on Earth and play essential roles in a wide range of ecological, medical, industrial processes. However, general principles that govern emergence biofilm architecture across different species remain unknown. Here, we combine experiments, simulations statistical analysis to identify shared biophysical mechanisms determine development at single-cell level, for Vibrio cholerae, Escherichia coli, Salmonella enterica...
Abstract The extracellular matrix is a defining feature of bacterial biofilms and provides structural stability to the community by binding cells surface each other. Transitions between biofilm initiation, growth, dispersion require different regulatory programs, all which result in modifications composition, abundance, or functionality. However, mechanisms individual disengage from enable their departure during dispersal are unclear. Here, we investigated active Vibrio cholerae nutrient...