A5024318680- Chronic Obstructive Pulmonary Disease (COPD) Research
- Heart Rate Variability and Autonomic Control
- Cardiovascular Syncope and Autonomic Disorders
- Asthma and respiratory diseases
- Cystic Fibrosis Research Advances
- Cardiovascular and exercise physiology
- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Hemodynamic Monitoring and Therapy
- Tracheal and airway disorders
- Neuroscience of respiration and sleep
- Congenital Heart Disease Studies
- Respiratory and Cough-Related Research
- Non-Invasive Vital Sign Monitoring
- Hemoglobinopathies and Related Disorders
- Respiratory viral infections research
- Inhalation and Respiratory Drug Delivery
- Delphi Technique in Research
- Obstructive Sleep Apnea Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Children's Physical and Motor Development
- Iron Metabolism and Disorders
- Sports Performance and Training
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiovascular Health and Disease Prevention
University of Minnesota
2018-2023
Twin Cities Orthopedics
2023
University of Minnesota Medical Center
2022
Mayo Clinic in Florida
2010-2019
University of Minnesota Rochester
2017-2019
Mayo Clinic
2007-2018
King's College Hospital NHS Foundation Trust
2017-2018
National Health Service
2018
WinnMed
2014-2017
Mayo Clinic in Arizona
2006-2016
Single measurements of peak oxygen uptake (VO2) have been shown to predict mortality in patients with cystic fibrosis (CF) although no longitudinal study serial has reported children. A was undertaken determine whether the initial, final, or rate fall forced expiratory volume 1 second (FEV1) VO2 a better predictor mortality.Twenty eight children aged 8-17 years CF performed annual pulmonary function and maximal exercise tests over 5 year period FEV1 VO2, magnitude their change time, survival...
Rationale. This study was designed to examine the relationships among weight, asthma severity, physical activity, and aerobic fitness in children with asthma. Subjects Methods. Sixty-four asthmatic 8 12 years old (53% female) were assessed while attending a summer camp. Measures included height spirometry, histamine bronchial provocation challenge, maximal power, questionnaires quantify habitual perceived activity limitations due asthma, competence attitudes toward activity. Asthma severity...
Bronchiolitis is the most common disease of lower respiratory tract in first year life. Treatment controversial, with studies giving conflicting views on benefits bronchodilators and steroids. The objectives this study were 1) to characterize management bronchiolitis pediatric emergency departments (PEDs) Canada, 2) determine patient outcomes following department (ED) visits, 3) provide descriptive data regarding symptoms family/personal medical history these patients.A prospective...
Postural tachycardia syndrome (POTS) is a heterogeneous condition. We stratified patients previously evaluated for POTS on the basis of supine resting cardiac output (CO) or with complaint platypnea "shortness breath" during orthostasis. hypothesize that postural hyperventilation one cause and hyperventilation-associated occurs when initial reduction in CO sufficiently large. also propose circulatory abnormalities normalize restoration
Variability of airway function is a feature asthma, spanning timescales from months to seconds. Short-term variation in resistance (R(rs)) elevated asthma and thought be due increased the contractile activation smooth muscle. If true, then R(rs) should decrease response bronchodilators, but this has not been investigated. Using forced oscillation technique, 4-34 Hz were measured 39 children with well-controlled mild-to-moderate 31 healthy controls (7-13 yrs) before after an inhaled...
Abstract Cross‐sectional data do not truly convey the manner in which declining lung function affects peak oxygen uptake (peak $\dot VO_2$ ) within a given patient with cystic fibrosis. We hypothesized that there would be concomitant decline FEV 1 over time. Twenty‐eight children aged 8–17 years fibrosis performed annual ergometer tests 5‐year period to determine and within‐patient predictors of change . Analysis was done using mixed‐effects model. During study period, averaged 2.7%...
Patients with sickle cell disease usually have mild hypoxaemia and their oxyhaemoglobin dissociation curve is shifted to the right. It follows that oxygen saturation in should be lower than normal. Most subjects this clinic had normal by pulse oximetry, however. To improve understanding of paradox, arterialised capillary tension (PO2) were compared simultaneously measured oximeter 20 children disease. In addition, PO2 at 50% haemoglobin (P50) was oximetry all patients. found was, on whole,...
Bronchiolitis is the most common cause of lower respiratory tract illness in infancy, and hospital admission rates appear to be increasing Canada United States. Inhaled beta agonists offer only modest short-term improvement. Trials racemic epinephrine have shown conflicting results. We sought determine if administration during stay for bronchiolitis improved distress, was safe, shortened length stay.The study a randomized, double-blind controlled trial aerosolized compared salbutamol every...
Background Congenital diaphragmatic hernia (CDH) is associated with lung hypoplasia. CDH survivors may have pulmonary morbidity that can decrease cardiopulmonary exercise. We aimed to examine whether exercise testing (CPET) results differ in versus healthy age-matched controls and CPET among according self-reported daily activity. Methods In one medical center Croatia, survivors—patients surgically corrected who were alive at age 5 years—were invited participate spirometry CPET. Values...
Definition Hemoptysis is defined as coughing up of blood or the presence in sputum. It not a common symptom children and although usually life-threatening, it can become so. Massive hemoptysis bleeding that exceeds 8 mL/kg per 24 hours. Because younger than 6 years age tend to swallow their sputum, they rarely present with hemoptysis, unless substantial. Epidemiology Etiology Causes are listed Table 1. Acute lower respiratory tract infection single most cause, accounting for approximately...
Previous studies comparing cardiac output (Q) and stroke volume (SV) between cystic fibrosis (CF) patients control subjects have shown conflicting results: some found lower SV in CF with severe airflow limitation, others showed no difference subjects. Methodologic problems could explain these discrepant findings. The aim of this study was to better characterize Q exercise mild as well obstruction. Subjects included 18 FEV1 ranging from 28 80% predicted without pulmonary hypertension, 16...
This descriptive population study of 307 public high school students, ages 15 to 17 years, was performed establish reference ranges for orthostatic changes in heart rate and blood pressure adolescents, identify influential variables. Noninvasive measurements were obtained. Reference change this at 2 minutes –2 +41 beats per minute 5 –1 +48 minute. Orthostatic within the adult range 98% adolescents tested. One-third participants experienced symptoms during testing. In conclusion, shows that...