A5051645303- Pharmaceutical Quality and Counterfeiting
- Pharmaceutical Economics and Policy
- Antibiotic Use and Resistance
- HIV/AIDS drug development and treatment
- Analytical Methods in Pharmaceuticals
- Global Maternal and Child Health
- Pesticide Residue Analysis and Safety
- Pneumonia and Respiratory Infections
- Reproductive Health and Contraception
- Malaria Research and Control
- Biosimilars and Bioanalytical Methods
- Phenothiazines and Benzothiazines Synthesis and Activities
- Pharmaceutical Practices and Patient Outcomes
- Hormonal and reproductive studies
- Quality and Safety in Healthcare
- Urinary Tract Infections Management
- Antibiotic Resistance in Bacteria
- HIV/AIDS Research and Interventions
- Analytical Chemistry and Chromatography
- Identification and Quantification in Food
- Sexual function and dysfunction studies
- HIV Research and Treatment
- Adolescent Sexual and Reproductive Health
- Health Systems, Economic Evaluations, Quality of Life
- Intellectual Property and Patents
Muhimbili University of Health and Allied Sciences
2024
Pharmaceuticals and Medical Devices Agency
2020
Tanzania Food and Nutrition Center
2018
University of Würzburg
2015-2018
Antimicrobial use (AMU) is one of the major drivers emerging antimicrobial resistance (AMR). The surveillance AMU, which a pillar AMR stewardship (AMS), helps devise strategies to mitigate AMR. This descriptive, longitudinal retrospective study quantified trends in human antibiotics utilization between 2010 and 2016 using data on all imported for systemic into Tanzania's mainland. Regression time series analyses were used establish use. A total 12,073 records retrieved, totaling 154.51...
Abstract Background Antimicrobial resistance (AMR) is a growing public health concern globally, and misuse of antibiotics major contributor. Objective This study investigated antibiotic utilization patterns before during the COVID-19 pandemic in Tanzania using data from Medicines Medical Devices Authority (TMDA). Methods retrospective longitudinal analysed secondary data. The compared consumption defined daily doses per 1000 inhabitants day (DID) two distinct eras: 2018–2019 as pre-COVID-19...
The quality of amoxicillin capsules, ceftriaxone for injection, and ciprofloxacin tablets was evaluated to determine whether there is any difference in when comparing the country origin. This undertaken because it has been claimed that antibiotics manufactured Europe are superior those originating from Africa or Asia.
Synopsis Background Antimicrobial resistance (AMR) is a growing public health concern globally, and misuse of antibiotics major contributor. Objective This study investigated antibiotic utilisation patterns before after the COVID-19 pandemic in Tanzania using data from Medicines Medical Devices Authority (TMDA). Methods retrospective longitudinal analysed secondary data. The compared consumption defined daily doses (DDD) per 1000 inhabitants day (DID) two distinct eras: 2018-2019 as...
Abstract Background Antiretroviral drugs (ARVs) have significantly reduced morbidity, mortality and improved the quality of life people living with HIV infection. Poor ARVs may result in harmful consequences such as adverse drug reactions, treatment failure development resistant strains sometimes death, which turn undermine healthcare delivery system. To ensure optimal outcomes, medicines control must be undertaken regularly. This study was aimed at evaluating circulating on Tanzania...
Veterinary medicines have been widely used for the prevention and treatment of animal diseases. Globally, veterinary medicine industry is growing. However, there a significant increase concern on quality in various developing countries' legal markets. Poor-quality are associated with failure, development drug resistance, increased healthcare cost, death. These reasons warrant need monitoring circulating Tanzania Mainland.This was survey study samples were collected from 9 out 26 regions...
Abstract Tanzania adopted a Dolutegravir (DTG)-based regimen as first-line treatment in 2019 following the World Health Organization recommendation. Data on DTG safety profile from sub-Saharan Africa including are limited. We investigated incidence of DTG-related adverse events (AEs) and associated factors among people living with HIV (PLHIV) initiated regimen. A prospective cohort study was conducted 25 Care Treatment Clinics mainland Tanzania. PLHIV aged 12 years above who were DTG-based...
Introduction Emergency contraceptives (ECs) are a critical method for preventing unwanted pregnancies following unprotected sexual intercourse. However, Tanzania is experiencing an alarming surge in the misuse of ECs among reproductive-aged females, particularly younger girls and women. Reports their use as regular rising concern. Deviations from intended emergencies may not only increase risk contraceptive failure but also adverse health events. This study aims to delineate evaluate...
Sustainable access to high-quality antimalarial medicines is pivotal achieving universal and effective malaria control. Poor-quality are prevalent in sub-Saharan Africa, impeding control initiatives claiming the lives of many children. Regular monitoring quality crucial ensure service community. A cross-sectional study using a postmarket surveillance (PMS) approach was conducted from 2019 2023. Samples were collected port entry, local manufacturers, various distribution outlets 15 regions...
Improving medicines regulation can lead to better population health, but how this process works in low- and middle-income countries remains underexplored. Tanzania's pharmaceutical sector is often cited as a successful example of well-functioning regulatory system developing country, attributed the work Tanzania Food Drugs Authority (TFDA), now Medicines Medical Devices (TMDA). This raises question: was capacity developed, what lessons other learn from experience? paper analyzes changes over...
Introduction Erectile dysfunction (ED) profoundly affects millions of people globally, including interfering with mental health and quality life. Phosphodiesterase type-5 inhibitors (PDE5Is) such as sildenafil are pivotal in ED treatment. This study aimed to examine the utilization patterns PDE5Is Tanzania. Materials methods In this retrospective longitudinal study, data on other similar imported between 2019 2023 were sourced from Tanzania Medicines Medical Devices Authority (TMDA)....
Good Manufacturing Practices (GMP) is the bedrock of quality assurance in pharmaceutical industry that ensures products are consistently produced and controlled according to standards. This study compared GMP conformance facilities across two fiscal years, 2018/2019 2019/2020, using East African Compendium on Practices, 2014, as a benchmark. We analyzed proportion foreign industries standards reported aggregated data over two-year period. Inspected had notable non-conformances, most commonly...
The global impact of antimicrobial resistance (AMR) includes increased morbidity and mortality rates healthcare costs, particularly in low- middle-income countries (LMICs), it has dire economic security implications. This study assessed the clinical isolates responsible for urinary tract infections (UTI) to antibacterial agents treating UTIs selected facilities Tanzania. A total 151 <i>E. coli</i> <i>S. aureus </i>isolated from urine...
<h3>Background</h3> The Covid-19 pandemic and other emerging diseases increased the need to conduct clinical trials (CTs) investigate appropriate treatments or prevention measures. One of main barriers for conducting CTs in Africa is delays regulatory ethics reviews. Furthermore, existence inadequate inspections evaluate integrity data submitted health authorities, protect patient safety, assess adequacy site/sponsor quality systems achieve same. To this end, ASCEND project assessed level...
Abstract Background Human Immunodeficiency Virus and Acquired Immune Deficiency Syndrome (HIV/AIDS) is still health problem worldwide, particularly in sub-Saharan African countries, such as Tanzania. Anti-retroviral medicines (ARVs) have significantly reduced morbidity, mortality improved the quality of life people living with HIV infection. Thus, good ARVs amongst key factors which guarantee successful therapeutic outcomes prevention development drug resistant strains. This study was aimed...
Abstract Background: Antiretroviral drugs (ARVs) have significantly reduced morbidity, mortality and improved the quality of life people living with HIV infection. Poor ARVs may result in harmful consequences such as adverse drug reactions, treatment failure, prolonged illness, development resistant strains sometimes death, which turn undermine healthcare delivery system. Thus, to ensure optimal outcomes, medicines control must be undertaken regularly. This study was aimed at evaluating...
Background: The use of substandard and falsified (SF) anti-tuberculosis (ant-TB) medicines may lead to treatment failure development drug resistance. SF medicinal products are claimed be more prevalent in developing countries with high burden tuberculosis disease. National Regulatory Authorities therefore, should ensure that the quality these life-saving is systematically monitored. We conducted a post marketing surveillance study determine the circulating on market Tanzania...