A5067217396- Advanced Electron Microscopy Techniques and Applications
- Microbial Metabolism and Applications
- RNA Research and Splicing
- Protein Kinase Regulation and GTPase Signaling
- Heat shock proteins research
- RNA and protein synthesis mechanisms
- Endoplasmic Reticulum Stress and Disease
- Lipid metabolism and biosynthesis
- Cancer Research and Treatments
University of Michigan
2025
University of California, San Diego
2021
Phospholipids are the most abundant component in lipid membranes and essential for structural functional integrity of cell. In eukaryotic cells, phospholipids primarily synthesized de novo through Kennedy pathway that involves multiple enzymatic processes. The terminal reaction is mediated by a group cytidine-5′-diphosphate (CDP)-choline /CDP-ethanolamine-phosphotransferases (CPT/EPT) use 1,2-diacylglycerol (DAG) CDP-choline or CDP-ethanolamine to produce phosphatidylcholine (PC)...
Synthetic nano- and microparticles have become essential tools in biotechnology. Protein-based compartments offer distinct advantages over synthetic particles, such as biodegradability biocompatibility, but their development is still its infancy. Bacterial microcompartments (BMCs) are protein-based organelles consisting of a protein shell encapsulating an enzymatic core. BMCs self-assembling, selectively permeable, modular, making them ideal candidates for the Indeed, several groups...
Abstract Phase separation is emerging as a universal principle for how cells use dynamic subcompartmentalization to organize biochemical reactions in time and space 1,2 . Yet, whether the emergent physical properties of these biomolecular condensates are important their biological function remains unclear. The intrinsically disordered protein PopZ forms membraneless at poles bacterium Caulobacter crescentus selectively sequesters kinase-signaling cascades regulate asymmetric cell division...