A5073587951- Complex Systems and Time Series Analysis
- Advanced Mathematical Theories and Applications
- Biofield Effects and Biophysics
- Computational Drug Discovery Methods
- Statistical Mechanics and Entropy
- Fractal and DNA sequence analysis
- Surfactants and Colloidal Systems
- Heart Rate Variability and Autonomic Control
- Medical Imaging Techniques and Applications
- Quantum Mechanics and Applications
- Radiation Therapy and Dosimetry
- Cardiovascular Health and Disease Prevention
- Nanoparticle-Based Drug Delivery
- Computational Physics and Python Applications
- Gene Regulatory Network Analysis
- Field-Flow Fractionation Techniques
- Advanced Drug Delivery Systems
- Advanced Thermodynamics and Statistical Mechanics
- Adipose Tissue and Metabolism
- Drug Solubulity and Delivery Systems
- Analytical Chemistry and Chromatography
- Radiopharmaceutical Chemistry and Applications
- Protein purification and stability
- Theoretical and Computational Physics
- Thermoelastic and Magnetoelastic Phenomena
Grigore T. Popa University of Medicine and Pharmacy
2015-2025
Alexandru Ioan Cuza University
2015-2017
Hai phong University Of Medicine and Pharmacy
2016
The demand for tailored, disease-adapted, and easily accessible radiopharmaceuticals is one of the most persistent challenges in nuclear imaging precision medicine. In this study, two radiotracers were developed to bind SPECT PET radionuclides.
The high energy of α emitters, and the strong linear transfer that goes along with it, lead to very efficient cell killing through DNA damage. Moreover, degree oxygenation cycle state have no impact on these effects. Therefore, radioisotopes can offer a treatment choice individuals who are not responding β- or gamma-radiation therapy chemotherapy drugs. Only few α-particle emitters suitable for targeted alpha (TAT) clinical applications. majority available research involves 225Ac its...
Assimilating complex systems to multifractal-type objects reveals continuous and non-differentiable curve dynamics, aligning with the Multifractal Theory of Motion. Two scenarios, a Schrödinger-type Madelung-type multifractal scenario, are possible in this setting. If Madelung scenario employs maximized information entropy for distribution density, then Newtonian oscillator-type forces can be determined. In presence these matter background, we analyze two-body problem. The obtained results...
In our work, we use the multifractal motion theory to apply a state density conservation law polymer-drug release process. This is specific transition from nonmultifractal curves corresponding processes. A diffusion-type was obtained, which describes cyclic drug dynamics until polymer matrix fully degraded. The system reveals programmable nature due its complex part and scale resolution dependence.
Background: Rheumatoid arthritis is a chronic autoimmune disease that leads to severe disability and requires improved therapeutic strategies optimize anti-inflammatory treatment. This study aimed address this challenge by developing characterizing an extended-release polymer matrix tablet containing ketoprofen ketoprofen–β-cyclodextrin complex with enhanced properties. The objective was improve inflammation management outcomes using novel delivery system based on the inclusion of active...
Background/Objectives: The Tc-99m dimercaptosuccinic acid (DMSA) renal scan clearly images the cortex, highlighting functional tissue areas and indicating regions of scarring, infection, malformations, or other types damage. To enhance management paediatric cases involving malformations to reduce incidence chronic progressive kidney diseases in "future adults", our study aims identify categorise various anomalies. Methods: This has been achieved by analysing DMSA scans a large cohort 931...
In multicellular organisms, both health and disease are defined by means of communication patterns involving the component cells. Despite intricate networks soluble mediators, cells also programed to exchange complex messages pre-assembled as multimolecular cargo membranous structures known extracellular vesicles (EVs). Several biogenetic pathways produce EVs with different properties able orchestrate neighboring cell reactions or establish an environment ripe for spreading tumor Such effect...
Two formulations based on diclofenac sodium salt encapsulated into a chitosan hydrogel were designed and prepared, their drug release was investigated by combining in vitro results with mathematical modeling. To understand how the pattern of encapsulation impacted its release, supramolecularly morphologically characterized scanning electron microscopy polarized light microscopy, respectively. The mechanism assessed using model multifractal theory motion. Various drug-delivery mechanisms,...
A unitary model of drug release dynamics is proposed, assuming that the polymer–drug system can be assimilated into a multifractal mathematical object. Then, we made description implies, via Scale Relativity Theory, functionality continuous and undifferentiable curves (fractal or curves), possibly leading to holographic-like behaviors. At such conjuncture, Schrödinger Madelung scenarios become compatible: in scenario, various modes “mimicked” (via period doubling, damped oscillations,...
Background: This study explored the potential of MCM-48 mesoporous silica matrices as a drug delivery system for metformin hydrochloride, aimed at improving therapeutic management type 2 diabetes mellitus. The objectives included synthesis and characterization MCM-48, assessment its loading capacity, analysis release profiles under simulated physiological conditions, development multifractal dynamics-based theoretical framework to model interpret kinetics. Methods: was synthesized using...
The present study analyzes (theoretically and experimentally) a drug release process from nanoparticles (polymeric nanocapsules liposomes). This is functionalized on the surface with an aptamer. These types of processes can also be included in cream-type formulations. obtained cream ensures active targeting tumor epithelial cells, case skin cancer, because it easily administered to by spreading, thus avoiding side effects caused toxicity healthy increasing both patient compliance...
A 62 years old woman was diagnosed with multinodular toxic goiter and primary hyperparathyroidism/left parathyroid adenoma by hormonal assessment, ultrasound nuclear thyroid/parathyroid scans. Cervical illustrated a aspect of the thyroid solid nodules cystic-component nodules; larger one represented complex necrosis areas in left lobe, ACR TI-RADS score 4 (moderately suspicious). Functional imaging performed for accurate differential diagnosis between vs. localization, cold hot nodules,...
The physicochemical properties of "smart" or stimuli-sensitive amphiphilic copolymers can be modeled as a function their environment. In special, pH-sensitive have practical applications in the biomedical field drug delivery systems. Interactions between structural units any polymer-drug system imply mutual constraints at various scale resolutions and nonlinearity is accepted one most fundamental properties. release kinetics, pH, model active principle, i.e., Curcumin, from nanomicelles...
The classical treatment of the Kepler problem leaves room for description space region central body by a hyperbolic geometry. If correspondence between empty and filled with matter is taken to be harmonic mapping, then atomic nucleus, like one Sun planetary system proper, described skyrmions. This fact makes possible nuclear within framework general relativity. “hedgehog” solution skyrmions can classically interpreted in terms characterizations intra-nuclear forces.
Nonlinear dynamics is nowadays widely employed in the study of biological phenomena.In such context, taking into account that abnormal heart rhythms display chaotic behaviours, our opinion, specific attractor can constitute a method for evaluating various cardiac afflictions.By using mathematical procedures to nonlinear we devise new atrial fibrillations.Using data from ECG signals, construct strange attractors corresponding phase space, analyzed signals.We show their reflect rhythms.The...
By employing mathematical procedures specific to non-linear dynamics, we devised a method for analyzing all the stages of an epileptic crisis. It can be seen that attractor (reconstructed in states space by time delay method) associated with each stage brain dynamics: normal functioning and crisis (pre-crisis, seizure, post-crisis). Moreover, since Hurst coefficient determined, state seizure characterized either calculating coefficient, or its fractal dimension.
By assimilating any complex system into a multifractal, new approach for describing the dynamics of such systems is proposed by means Multifractal Theory Motion. In context, description these accomplished through continuous and non-differentiable curves (multifractal curves), giving rise to two scenarios. The first scenario Schrödinger-type multifractal scenario, situation in which motion laws can be related SL(2R) algebra invariant functions. second Madelung-type if differentiable...