A5092043193- Neuroscience of respiration and sleep
- Obstructive Sleep Apnea Research
- Neuropeptides and Animal Physiology
- Cardiovascular and Diving-Related Complications
- Photoreceptor and optogenetics research
- S100 Proteins and Annexins
- Traumatic Brain Injury and Neurovascular Disturbances
- Atherosclerosis and Cardiovascular Diseases
- Sleep and Wakefulness Research
- Mitochondrial Function and Pathology
- Adipokines, Inflammation, and Metabolic Diseases
- Pain Mechanisms and Treatments
- Cell Adhesion Molecules Research
Third Affiliated Hospital of Sun Yat-sen University
2025
Sun Yat-sen University
2025
University of Central Florida
2023-2024
MBF Bioscience (United States)
2023
University of Auckland
2023
Purpose: Inflammatory activation of immune cells plays a pivotal role in the development coronary artery diseases (CAD). This study aims to investigate responses peripheral blood mononuclear (PBMCs) CAD and identify novel signature genes biomarkers using machine learning algorithms. Methods: The GSE113079 dataset was analyzed differentially expressed (DEGs) were identified between normal samples. intersection DEGs with inflammation-related used (DIRGs). Then, receiver operating...
Abstract Chronic intermittent hypoxia (CIH, a model for sleep apnoea) is major risk factor several cardiovascular diseases. Autonomic imbalance (sympathetic overactivity and parasympathetic withdrawal) has emerged as causal contributor of CIH‐induced disease. Previously, we showed that CIH remodels the pathway. However, whether induces remodelling cardiac sympathetic innervation remains unknown. Mice (male, C57BL/6J, 2–3 months) were exposed to either room air (RA, 21% O 2 ) or (alternating...
Chronic intermittent hypoxia (CIH) is a widely employed model for sleep apnea. The imbalance of autonomic control may contribute to CIH-induced cardiovascular diseases. Previously, we demonstrated that CIH increases sympathetic innervation the atria. In this study, determined whether remodels peripheral cardiac tyrosine hydroxylase (TH, marker efferent axons) in whole ventricles. two challenges here were: 1) labeling entire TH-IR axon full thickness (~500 μm) flat-mount 2) Quantifying...
It is important to understand the topographical distribution of nociceptive axons in heart treat cardiac pain. While previous studies have detected sectioned heart, their full has not been fully explored, particular, pattern differences male and female mice determined. In this study, we performed a mapping afferent flat-mounts whole (C57BL/6J, & female, 3-5 months, n=6 for each gender) using calcitonin gene-related peptide (CGRP) as marker. Then, used confocal microscope Zeiss M2 Imager...
Chronic intermittent hypoxia (CIH, a model for sleep apnea) is major risk factor several cardiovascular diseases (CVD). Autonomic imbalance (sympathetic overactivity and parasympathetic withdrawal) has emerged as causal contributor of CIH-induced CVD. Previously, we showed that CIH remodels the pathway. However, whether induces remodeling cardiac sympathetic innervation remains unknown. Mice (male, C57BL/6J, 2-3 months) were exposed to either room air (RA, 21% O2) or (alternating 5.7% O2,...