A5087196083- Peroxisome Proliferator-Activated Receptors
- Cancer, Lipids, and Metabolism
- Inflammatory mediators and NSAID effects
- Metabolism, Diabetes, and Cancer
- Melanoma and MAPK Pathways
- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Nuclear Receptors and Signaling
- Extracellular vesicles in disease
- Redox biology and oxidative stress
- Neuroinflammation and Neurodegeneration Mechanisms
- Food Allergy and Anaphylaxis Research
- RNA and protein synthesis mechanisms
- NF-κB Signaling Pathways
- Molecular Biology Techniques and Applications
- Genomics and Phylogenetic Studies
- Asthma and respiratory diseases
- Pain Mechanisms and Treatments
- Cell Adhesion Molecules Research
University of Lausanne
2013-2021
SIB Swiss Institute of Bioinformatics
2019
University Hospital of Lausanne
2017
Abstract The Eukaryotic Promoter Database (EPD), available online at https://epd.epfl.ch, provides accurate transcription start site (TSS) information for promoters of 15 model organisms plus corresponding functional genomics data that can be viewed in a genome browser, queried or analyzed via web interfaces, exported standard formats (FASTA, BED, CSV) subsequent analysis with other tools. Recent work has focused on the improvement EPD promoter viewers, which use UCSC Genome Browser as...
Glutamate transport through astrocytic excitatory amino-acid transporters (EAAT)-1 and EAAT-2 is paramount for neural homeostasis. EAAT-1 has been reported in secreted extracellular microvesicles (eMV, such as exosomes) because the Protein Kinase C (PKC) family controls sub-cellular distribution of EAATs, we have explored whether PKCs drive EAATs into eMV. Using rat primary astrocytes, confocal immunofluorescence ultracentrifugation on sucrose gradient here report that PKC activation by...
Abstract In addition to improving insulin sensitivity in type 2 diabetes, the thiazolidinedione family of compounds and pharmacologic activation their best-characterized target PPARγ have been proposed as a therapeutic option for cancer treatment. this study, we reveal new mode action rosiglitazone that can contribute tumorigenesis. Rosiglitazone activated tumorigenic paracrine communication program subset human melanoma cells involves secretion cytokines, chemokines, angiogenic factors....
Abstract The thioredoxin system plays key roles in regulating cancer cell malignancy. Here we identify the Thioredoxin-interacting protein ( TXNIP ) as a gene, which expression is regulated by PPARγ melanoma cells. We show that high levels associate with benign melanocytic lesions, tumor regression patients on MAP kinase targeted therapy, decreased proliferation patients’ biopsies, and cycle arrest human lines. In contrast, reduced associates advanced disease progression patients. depletion...
<p>Four supplementary figures showing - PPARg activation regulates pro-inflammatory cytokine expression in A375 melanoma cells Impact of RGZ exposure on the PPARg-target genes and cytokines a variety cancer cell lines direct to or T0070907 interleukin receptor expression, proliferation, cycle, apoptosis senescence cells, human fibroblasts, endothelial monocytes RGZ-conditioned media collected from different murine fibroblasts cells</p>
<p>Supplementary Materials and methods</p>
<div>Abstract<p>In addition to improving insulin sensitivity in type 2 diabetes, the thiazolidinedione family of compounds and pharmacologic activation their best-characterized target PPARγ have been proposed as a therapeutic option for cancer treatment. In this study, we reveal new mode action rosiglitazone that can contribute tumorigenesis. Rosiglitazone activated tumorigenic paracrine communication program subset human melanoma cells involves secretion cytokines, chemokines,...
<p>Four supplementary figures showing - PPARg activation regulates pro-inflammatory cytokine expression in A375 melanoma cells Impact of RGZ exposure on the PPARg-target genes and cytokines a variety cancer cell lines direct to or T0070907 interleukin receptor expression, proliferation, cycle, apoptosis senescence cells, human fibroblasts, endothelial monocytes RGZ-conditioned media collected from different murine fibroblasts cells</p>
<div>Abstract<p>In addition to improving insulin sensitivity in type 2 diabetes, the thiazolidinedione family of compounds and pharmacologic activation their best-characterized target PPARγ have been proposed as a therapeutic option for cancer treatment. In this study, we reveal new mode action rosiglitazone that can contribute tumorigenesis. Rosiglitazone activated tumorigenic paracrine communication program subset human melanoma cells involves secretion cytokines, chemokines,...
<p>Supplementary Materials and methods</p>