A5061467273- Chemical Synthesis and Analysis
- Supramolecular Chemistry and Complexes
- Molecular Sensors and Ion Detection
- Photoreceptor and optogenetics research
- Supramolecular Self-Assembly in Materials
- Computational Drug Discovery Methods
- Photochromic and Fluorescence Chemistry
- Microbial Natural Products and Biosynthesis
- Synthesis and Catalytic Reactions
- Click Chemistry and Applications
University of Groningen
2013-2017
Centre for Structural Systems Biology
2014
Dialyse Centrum Groningen
2014
A family of self-replicating macrocycles was developed using dynamic combinatorial chemistry. Replication is driven by self-assembly the replicators into fibrils and relies critically on mechanically induced fibril fragmentation. Analysis separate libraries made from one six peptide-functionalized building blocks different hydrophobicity revealed two selection criteria that govern emergence these systems. First, need to have a critical macrocycle size endows them with sufficient multivalency...
Abstract In biology enzyme concentrations are continuously regulated, yet for synthetic catalytic systems such regulatory mechanisms underdeveloped. We now report how a substrate of chemical reaction induces the formation its own catalyst from dynamic molecular network. After complete conversion substrate, network disassembles catalyst. These results open up new opportunities controlling catalysis in systems.
Photoisomerization provides a clean and efficient way of reversibly altering physical properties chemical systems injecting energy into them. These effects have been applied in development such as photoresponsive materials, molecular motors, photoactivated drugs. Typically, switching from more to less stable isomer(s) is performed by irradiation with UV or visible light, while the reverse process proceeds thermally using another wavelength. In this work we developed method rapid tunable Z→E...
Abstract Fragment‐based drug design (FBDD) affords active compounds for biological targets. While there are numerous reports on FBDD by fragment growing/optimization, linking has rarely been reported. Dynamic combinatorial chemistry (DCC) become a powerful hit‐identification strategy We report the synergistic combination of and DCC to identify inhibitors aspartic protease endothiapepsin. Based X‐ray crystal structures endothiapepsin in complex with fragments, we designed library...
A series of dynamic combinatorial [2] and [3]catenanes have been prepared. Formation the occurs with positive or negative cooperativity, depending on cyclodextrin homologue. Systems level analysis allows cooperativity to be quantified MD simulations reveal that derives from extents which hydrophobic surface area is exposed aqueous surroundings.
Abstract In biology enzyme concentrations are continuously regulated, yet for synthetic catalytic systems such regulatory mechanisms underdeveloped. We now report how a substrate of chemical reaction induces the formation its own catalyst from dynamic molecular network. After complete conversion substrate, network disassembles catalyst. These results open up new opportunities controlling catalysis in systems.
Abstract Fragmentbasiertes Wirkstoffdesign (FBWD) führt zu pharmakologisch aktiven Substanzen für biologische Targets. Obschon es zahlreiche Beispiele FBWD anhand von Fragmentwachstum und ‐optimierung gibt, wird die Verknüpfung Fragmenten nur selten verwendet. Dynamische kombinatorische Chemie (DKC) ist einer erfolgreichen Strategie Identifizierung Hits Targets herangewachsen. Wir berichten hier über synergistische Kombination Fragmentverknüpfung DKC, um Inhibitoren der Aspartylprotease...