A5003664180- MicroRNA in disease regulation
- Chemotherapy-induced organ toxicity mitigation
- RNA Research and Splicing
- Extracellular vesicles in disease
- Cancer Mechanisms and Therapy
- Cell death mechanisms and regulation
- Circular RNAs in diseases
Instituto Politécnico Nacional
2020
Centro de Investigación en Materiales Avanzados
2018
Background: Aberrant miRNA expression is associated with the development of several diseases including cervical cancer. Dysregulation miR-125a-5p present in a plethora tumors, but its role cancer not well understood. Objective: The aim was to analyze profile tumor and immortal cell lines further target prediction, validation function analysis. Methods: MiR-125a-5p determined by real-time RT-PCR from nine lines. In silico tools were used find transcripts an miR-125-5p complementary site...
The main treatment alternative for cervical cancer is cisplatin chemotherapy. However, the resistance of tumor cells to cisplatin, in addition side effects, limits its use. flavonoid naringenin has shown cytotoxic effects on and may be considered as a coadjuvant cancer. In present study, effect cell viability, cytotoxicity, proliferation, apoptosis invasion was evaluated HeLa spheroid cultures. Naringenin impaired viability indicated by low ATP levels caused concentration- time-dependent...