A5019566370- Nerve injury and regeneration
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Autism Spectrum Disorder Research
- Medicinal Plants and Neuroprotection
- Nuclear Receptors and Signaling
- Anesthesia and Neurotoxicity Research
- Aluminum toxicity and tolerance in plants and animals
- RNA Interference and Gene Delivery
- Curcumin's Biomedical Applications
- Organ Transplantation Techniques and Outcomes
- Obsessive-Compulsive Spectrum Disorders
- RNA Research and Splicing
- Photoreceptor and optogenetics research
- Liver physiology and pathology
- Virus-based gene therapy research
- Neuroscience and Neuropharmacology Research
- DNA and Nucleic Acid Chemistry
- Origins and Evolution of Life
- Complementary and Alternative Medicine Studies
- Pharmacological Effects of Medicinal Plants
- Neurological Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Inflammation biomarkers and pathways
- Photosynthetic Processes and Mechanisms
Universidad Veracruzana
2024
International Development Research Centre
2023
Rajiv Gandhi University of Knowledge Technologies
2019-2022
Sri Venkateswara University
2020
Sri Padmavati Mahila Visvavidyalayam
2018-2019
ORCID
2018
Christian Medical College & Hospital
2017
Christian Medical College
2017
Instituto Politécnico Nacional
2014-2015
Institut Català de Nanociència i Nanotecnologia
2014
The neurotrophin Brain-Derived Neurotrophic Factor (BDNF) influences nigral dopaminergic neurons via autocrine and paracrine mechanisms. reduction of BDNF expression in Parkinson's disease substantia nigra (SN) might contribute to the death because inhibiting SN causes parkinsonism rat. This study aimed demonstrate that increasing rats with one week 6-hydroxydopamine lesion recovers from parkinsonism. plasmids phDAT-BDNF-flag phDAT-EGFP, coding for enhanced green fluorescent protein, were...
The anti-inflammatory effect of the cerebral dopamine neurotrophic factor (CDNF) was shown recently in primary glial cell cultures, yet such remains unknown both vivo and 6-hydroxydopamine (6-OHDA) models Parkinson's disease (PD). We addressed this issue by performing an intranigral transfection human CDNF (hCDNF) gene critical period inflammation after a single intrastriatal 6-OHDA injection rat. At day 15 lesion, plasmids p3xNBRE-hCDNF or p3xNBRE-EGFP, coding for enhanced green florescent...
Asymmetric hydrocarbon chains influence the efficiency of cationic lipids based liposomes in nucleic acid delivery. A systematic investigation role asymmetry transfection efficiency.
Living Donor Liver Transplantation (LDLT) is a promising approach to treating end-stage liver diseases, however, some post-operatory complications such as pneumonia, bacteremia, urinary tract infections, and hepatic dysfunction have been reported. In murine models using partial hepatectomy (PHx), model that emulates LDLT, it has determined the synthesis of cell proliferation factors are associated with noradrenaline produced in locus coeruleus (LC). addition, studies shown PHx decreases GABA...
Neurotensin (NTS)-polyplex is a multicomponent nonviral vector that enables gene delivery via internalization of the neurotensin type 1 receptor (NTSR1) to dopaminergic neurons and cancer cells. An approach improving its therapeutic safety replacing viral karyophilic component (peptide KPSV40; MAPTKRKGSCPGAAPNKPK), which performs nuclear import activity, by shorter synthetic peptide (KPRa; KMAPKKRK). We explored this issue mechanism plasmid DNA translocation through expression green...
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Overexpression of neurotrophic factors in nigral dopamine neurons is a promising approach to reverse neurodegeneration the nigrostriatal system, hallmark Parkinson’s disease. The human cerebral factor (hCDNF) has recently emerged as strong candidate for disease therapy. This study shows that hCDNF expression using neurotensin-polyplex nanoparticle system reverses 6-hydroxydopamine-induced morphological, biochemical, and behavioral alterations. Three independent electron microscopy techniques...
Los iones metálicos con actividad biológica como el cobalto, cobre, cromo, hierro y magnaneso participan en la nutrición, respiración, mantenimiento comunicación celular. Otros arsénico, cadmio, mercurio plomo, que si bien son importantes para dinámica de suelos ecosistemas, no parte del homeostásis celular, por contrario su acumulación exacerbada organismo puede favorecer alteraciones patofisiológicas. En los últimos años, exposición a tóxicos ha ido aumento debido consumo alimentos, o...
The peripheral inflammatory stimulus could induce cell damage in organs and activate microglial cells the brain. One such was given to adult male Wistar rats by injecting different concentrations of lipopolysaccharide (LPS; 50, 300, 500 g/kg 5 mg/kg i.p.). To verify systemic effect LPS administration, serum content C-reactive protein (CRP), variation body weight cellular changes spleen, liver kidney were determined. Motor impairment evaluated rotarod open field tests. Microglia activation...
Pharmacognosy Research,2020,12,4,380-386.DOI:10.4103/pr.pr_18_20Published:January 2021Type:Original ArticleAuthors:Swathi Ganna, Rajasekhara Reddy Gutturu, Rajesh Megala, Rasajna Nadella, Deva Prasad Raju Borelli, and John Sushma Nannepaga Author(s) affiliations:Swathi Ganna1, Gutturu2, Megala3, Nadella4, Borelli3, Nannepaga1 1Department of Biotechnology, Sri Padmavati Mahila Visvavidyalayam, Tirupati, Andhra Pradesh, INDIA. 2Department Instrumentation, Venkateswara University, 3Department...
Sunlight that is harvested by photosynthetic organisms provides a blueprint for the solar energy storage systems. Substantial use of to meet several needs humanity will require huge storage, which one greatest barriers adoption renewable and this an area where proteins can play key role. One such protein identified so far bacteriorhodopsin (bR), produced salt marsh archaea, Halobacterium salinarum; generate via photosynthesis. The optical electrical properties bR produce unique...
Abstract Background Dasapatrachurnam (DPC), a multicurative powder prepared from the leaves of 10 green leafy vegetables, was developed recently with known ethnobotanical and ethnopharmacological significance. However, its functional role in curing disease is not yet scientifically proven. The present study aims at performing phytochemical screening DPC exploring possible activity as bacteriostatic, antineoplastic anti-inflammatory. Methods We performed qualitative Fourier transform infrared...