A5017234439- Cerebral Palsy and Movement Disorders
- Cardiovascular and exercise physiology
- Dialysis and Renal Disease Management
- Muscle metabolism and nutrition
- Nutrition and Health in Aging
- Adipose Tissue and Metabolism
- Cardiovascular Function and Risk Factors
- Spinal Dysraphism and Malformations
- Sports Performance and Training
- Congenital heart defects research
- Diet and metabolism studies
- Sports injuries and prevention
- Shoulder Injury and Treatment
- Hip disorders and treatments
- Cardiomyopathy and Myosin Studies
- Mitochondrial Function and Pathology
- Muscle activation and electromyography studies
- Foot and Ankle Surgery
- Body Composition Measurement Techniques
- Cardiovascular Effects of Exercise
- Long-Term Effects of COVID-19
- Knee injuries and reconstruction techniques
- Hydrogen's biological and therapeutic effects
- Bone fractures and treatments
- Family and Disability Support Research
Sapporo Medical University
2021-2024
National Hospital Organization Hokkaido Medical Center
2020-2023
Abstract The initiation of heartbeat is an essential step in cardiogenesis the heart primordium, but it remains unclear how intracellular metabolism responds to increased energy demands after initiation. In this study, embryos Wistar rats at embryonic day 10, which begins rats, were divided into two groups by primordium before and their metabolic characteristics assessed. Metabolome analysis revealed that levels ATP, a main product glucose catabolism, reduced glutathione, by-product pentose...
Abstract Although platelet‐rich plasma (PRP) has been widely used regardless of the severity muscle strain, there have very few basic studies in which its effects on injury were examined by using models that accurately mimic clinical strain process. Therefore, aim this study was to confirm physiological and structural analyses whether PRP purified a general preparation method healing effect damage caused eccentric contraction (ECC). Male Wistar rats subjected induced ECC bilateral plantar...
Interval training (IT) results in improved fatigue resistance skeletal muscle mainly due to an increased aerobic capacity, which involves mitochondrial content and/or function. We hypothesized that IT with high-intensity contractions is more effective increasing function, and hence resistance, than low-intensity contractions. To study this hypothesis without interference from differences fiber recruitment obliged occur during voluntary contractions, was performed situ supramaximal electrical...
Chronic kidney disease (CKD)-related cachexia increases the risks of reduced physical activity and mortality. However, physiological phenotype skeletal muscle fatigue changes in intramuscular metabolites during CKD-related remain unclear. In present study, we performed detailed evaluation, analysis mitochondrial function, comprehensive metabolic before after a 5/6 nephrectomized rat model CKD. Wistar rats were randomized to sham-operation (Sham) group that served as control or nephrectomy...
Background Exercise, especially high-intensity interval training (HIIT), can increase mitochondrial respiratory capacity and enhance muscular endurance, but its systemic burden makes it difficult to safely continuously prescribe for patients with chronic kidney disease (CKD)-related cachexia who are in poor general condition. In this study, we examined whether HIIT using electrical stimulation (ES), which does not require whole-body exercise, improves muscle endurance the skeletal of 5/6...
In high-intensity and sprint interval training, the frequency of contractions is typically higher compared to moderate-intensity continuous but it remains unclear whether this contributes effective increase in fatigue resistance mechanisms. Here, we investigated role contraction training on endurance adaptations mouse skeletal muscle. Male C57BL/6 mice were divided into groups based high (0.25 s every 0.5 s) low 4.5 frequencies, with either 360 per session (Hi360 Lo360) or 30 (Hi30 Lo30)....
Myofibrillogenesis is an essential process for cardiogenesis and closely related to excitation-contraction coupling the maintenance of heartbeat. It remains unclear whether formation myofibrils sarcomeres associated with heartbeat initiation in early embryonic heart development. Here, we investigated association between ultrastructure assessed by transmission electron microscopy their proteomic profiling data-independent acquisition mass spectrometry (DIA-MS) rat primordia before after at...
Quantitative data assessment on the basis of three-dimensional gait analysis has been routinely used in evaluation pathological children with cerebral palsy. However, a similar quantitative methodology not applied for spina bifida patients whom atypical patterns are thought to correlate various levels neurological paralysis. The purpose this study is investigate differences among between different lesions using methods: Gait profile score (GPS) and variable scores (GVS), scoring subject's...
Background: There are numerous etiologies relating to physeal arrest. The clinical manifestations of arrest may include limb length discrepancy (LLD) and bone malalignment, especially in younger children with more growth ahead them.