A5017482073- Synthesis and biological activity
- Click Chemistry and Applications
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Biological Evaluation
- Ionic liquids properties and applications
- Multicomponent Synthesis of Heterocycles
- Microwave-Assisted Synthesis and Applications
- Corrosion Behavior and Inhibition
- Computational Drug Discovery Methods
- Concrete Corrosion and Durability
- Phenothiazines and Benzothiazines Synthesis and Activities
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Metal complexes synthesis and properties
- Toxoplasma gondii Research Studies
- Metal-Organic Frameworks: Synthesis and Applications
- Crystal structures of chemical compounds
- Electrochemical Analysis and Applications
- Pneumocystis jirovecii pneumonia detection and treatment
- Chemistry and Chemical Engineering
- Catalytic Cross-Coupling Reactions
- Cancer therapeutics and mechanisms
- Adenosine and Purinergic Signaling
- Protease and Inhibitor Mechanisms
- Structural and Chemical Analysis of Organic and Inorganic Compounds
Taibah University
2016-2025
Université des Sciences et de la Technologie d'Oran Mohamed Boudiaf
2009-2020
University of the Sciences
2014
Alexandria University
2006-2009
Mustansiriyah University
2005
New conjugates of substituted 1,2,3-triazoles linked to 1,2,4-triazoles were synthesized starting from the appropriate S-propargylated 7 and 8. Ligation 1,2,3-triazole core was performed through Cu(I)-catalyzed cycloaddition 1,2,4-triazole-based alkyne side chain and/or 8 with several un/functionalized alkyl- aryl-substituted azides 9–15 afford desired 1,4-disubstituted 16–27, using both classical microwave methods. After their spectroscopic characterization (infrared, 1H, 13C nuclear...
COVID-19 infection is now considered one of the leading causes human death. As an attempt towards discovery novel medications for pandemic, nineteen compounds containing 1,2,3-triazole side chains linked to phenylpyrazolone scaffold and terminal lipophilic aryl parts with prominent substituent functionalities were designed synthesized via a click reaction based on our previous work. The assessed using in vitro effect growth SARS-CoV-2 virus-infested Vero cells different compound...
SARS-CoV-2 and its variants, especially the Omicron variant, remain a great threat to human health. The need discover potent compounds that may control virus pandemic emerged mutants is rising. A set of 1,2,3-triazole and/or 1,2,4-triazole was synthesized either from benzimidazole or isatin precursors. Molecular docking studies in vitro enzyme activity revealed most investigated demonstrated promising binding scores against spike proteins, comparison reference drugs. In particular, compound...
A new class of C 3-symmetry porous ionic polymers, tethering triazine (benzene) core hybrids, was successfully prepared and used for room-temperature CO 2 sensing.
In the present study, a new series of 2,5-disubstituted-1,3,4-thiadiazole tethered 1,2,4-triazole, 1,3,4-thiadiazole, 1,3,4-oxadiazole and Schiff base derivatives were synthesized characterized by IR, 1H-NMR, 13C-NMR, MS elemental analyses. All compounds screened for their antibacterial, antifungal antiproliferative activity. Some have displayed promising biological
A library of novel regioselective 1,4-di and 1,4,5-trisubstituted-1,2,3-triazole based benzothiazole-piperazine conjugates were designed synthesized using the click synthesis approach in presence absence Cu(I) catalyst. Some these 1,2,3-triazole hybrids possess their structures different heterocyclic scaffold including 1,2,4-triazole, benzothiazole, isatin and/or benzimidazole. The newly assessed for antiproliferative inhibition potency against four selected human cancer cell lines (MCF7,...
A novel synthesized chromene-1,2,3-triazole benzene sulfonamide exhibited potent apoptosis induction through carbonic anhydrase-IX inhibition against prostate cancer.
1,2,4-Triazoles and 1,2,3-triazoles have gained significant importance in medicinal chemistry.
Newer imidazolium ionic liquid (IL) halides 4a–f appending variety of fluorinated phenylacetamide side chains were designed and synthesized through quaternization 1-methyl and/or 1,2-dimethylimidazole with appropriate 2-chloro-N-(fluorinatedphenyl)acetamides. The resulting ILs converted to their respective analogues carrying counteranions (PF6–, BF4–, CF3COO–) 5a–r. All newly fully characterized using several spectroscopic experiments such as 1H, 13C, 11B, 19F, 31P NMR, mass analysis....
The highly contagious nature of Covid-19 attracted us to this challenging area research, mainly because the disease is spreading very fast and until now, no effective method a safe treatment or vaccine developed. A library novel 1,2,3-triazoles based 1,2,4-triazole, 1,3,4-oxadiazole and/or 1,3,4-thiadiazole scaffolds were designed successfully synthesized. Different spectroscopic tools efficiently characterized all newly synthesized hybrid molecules. An interesting finding that some...
Tuberculosis (TB) caused by Mycobacterium tuberculosis is still a serious public health concern around the world. More treatment strategies or more specific molecular targets have been sought researchers. One of most important M. tuberculosis' enoyl-acyl carrier protein reductase InhA which considered promising, well-studied target for anti-tuberculosis medication development. Our team has made it goal to find new lead structures that could be useful in creation antitubercular drugs. In this...
A library of novel imidazole-1,2,3-triazole hybrids were designed and synthesized based on the hybrid pharmacophore approach. Therefore, copper(I)catalyzed click reaction thiopropargylated-imidazole 2 with several organoazides yielded two sets carrying different un/functionalized alkyl/aryl side chains 4a–k 6a–e. After full spectroscopic characterization using spectral techniques (IR, 1H, 13C NMR) elemental analyses, resulted adducts screened for their anticancer activity against four cancer...
Schiff bases encompassing a 1,2,3-triazole motif were synthesized using an efficient multi-step synthesis. The formations of targeted base ligands confirmed by different spectroscopic techniques (FT-IR, 1H NMR, 13C and CHN analysis). spectral data analysis revealed that the newly designed hydrazones exist as mixture trans-E cis-E diastereomers. Densityfunctional theory calculations (DFT) for showed trans-trans form has lowest energy structure with maximum stability compared to other possible...