Manipulation of immune checkpoints such as CTLA4 or PD-1 with targeted antibodies has recently emerged an effective anticancer strategy in multiple malignancies. Sarcomas are a heterogeneous group diseases need more treatments. Different subtypes soft tissue and bone sarcomas have been shown to express ligand. We retrospectively analyzed cohort patients (pts) relapsed metastatic/unresectable sarcomas, who were treated nivolumab provided under patient assistance program from the manufacturer....

Acute myeloid leukemia (AML) is a hematologic malignancy with poor prognosis, often presenting systemic and extramedullary manifestations. Leukemia cutis (LC), the infiltration of leukemic cells into skin, rare clinically significant complication AML. It signals disease involvement, may precede relapse, associated survival outcomes. We report case 36-year-old female AML who developed recurrent, reddish-brown nodular skin lesions on face, trunk, extremities, consistent LC. Despite achieving...

Prior research has shown substantial shifts in procedure shares between specialty groups providing lumbar punctures. Our aim was to analyze national trends punctures among the Medicare population from 2010 2018.Medicare Part B Physician/Supplier Procedure Summary Master Files 2018 were analyzed for all Current Procedural Terminology, Version 4 codes related (62270 and 62272). Lumbar puncture volume utilization rates assessed stratified by place of service background providers.From 2018,...

Multiple myeloma is a plasma cell neoplasm, which may present as solitary plasmacytoma and, uncommonly, an extramedullary plasmacytoma. Intracranial plasmacytomas manifest in central nervous system involvement cranial nerve palsies. Cranial six palsy the most common cases of malignancy. However, isolated abducens presenting multiple recurrence very uncommon. Here, we detail two intracranial lesions were within region Dorello canal, resulting acute unilateral diplopia from disease absence...

Multiple myeloma is a plasma cell neoplasm, which may present as solitary plasmacytoma and, uncommonly, an extramedullary plasmacytoma. Intracranial plasmacytomas manifest in central nervous system involvement cranial nerve palsies. Cranial six palsy the most common cases of malignancy. However, isolated abducens presenting multiple recurrence very uncommon. Here, we detail two intracranial lesions were within region Dorello canal, resulting acute unilateral diplopia from disease absence...

Solitary fibrous tumors are fibroblastic mesenchymal neoplasms that also include what was previously known as hemangiopericytoma. Dedifferentiation of solitary is rare and usually manifests a high-grade sarcoma. We report case dedifferentiation an intracranial leptomeningeal tumor to rhabdomyosarcoma in 65-year-old female. The initial biopsy demonstrated purely STAT6 positive anaplastic hemangiopericytoma overlying the occipital lobe with no evidence rhabdomyosarcomatous component. Four...

We aim to assess the functional magnetic resonance (fMRI) utilization trends among Medicare population from 2007-2018. Part B Physician/Supplier Procedure Summary master files 2010-2018 and National Data Files 2007-2018 were analyzed for all Current Procedural Terminology, version 4 (CPT-4) codes related fMRI (70554, 70555, 96020). The provided total procedure volume payments. specialty used determine provider specialty. place-of-service identify locations where services provided. rate...

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a small vessel disease that commonly presents ischemic episodes, cognitive deficits, migraine aura, psychiatric disturbances.It caused by mutations in the NOTCH3 gene of which several specific point have been identified.We report 59year-old female confirmed CADASIL diagnosis, an atypical presentation, unreported mutation.She presented stroke-like symptoms MRI was initially read as subacute...

Evaluation for intracranial hemorrhage is a common indication when performing imaging of the head in emergency setting. We present rare case active, spontaneous extravasation blood into brain parenchyma, which evolved during magnetic resonance examination. A 70-year-old woman who had no previous history hypertension or trauma underwent confusion and dysarthria. Initial sequences did not demonstrate an acute cerebral hemorrhage; however, subsequent fluid-attenuated inversion recovery, T2-...

The novel coronavirus disease-2019 (COVID-19) illness and deaths, caused by the severe acute respiratory syndrome coronavirus-2, continue to increase. Multiple reports highlight thromboembolic complications, such as pulmonary embolism (PE), in COVID-19. Imaging plays an essential role diagnosis management of COVID-19 patients with PE. There continues be a rapid evolution knowledge related associated This review summarizes current understanding prevalence, pathophysiology, diagnostic imaging...

ABSTRACT Aim and objective Magnetic resonance imaging (MRI) of pelvis as a one-stop shop modality for locoregional staging carcinoma the cervix. Compare MRI with clinical Materials methods We conducted pelvic examinations on histological proved 83 cases cervical 1.5 T scanner. Results demonstrated mass in 79 out (95%) patients. No lesion was 4 patients, who were clinically diagnosed stage I. X 2 test value 43.6 p < 0.01 indicating significant difference between by that staging. Z score...