A5062852618- Dialysis and Renal Disease Management
- Acute Kidney Injury Research
- Pharmacological Effects and Toxicity Studies
- Salivary Gland Disorders and Functions
- Renal Transplantation Outcomes and Treatments
- Obstructive Sleep Apnea Research
- Chronic Kidney Disease and Diabetes
- Cardiac electrophysiology and arrhythmias
- Analytical chemistry methods development
- Metabolomics and Mass Spectrometry Studies
- Hemodynamic Monitoring and Therapy
- Thyroid Disorders and Treatments
- Pharmacogenetics and Drug Metabolism
- Trace Elements in Health
- Analytical Chemistry and Chromatography
- Celiac Disease Research and Management
- Muscle and Compartmental Disorders
- Forensic Toxicology and Drug Analysis
- Dental Health and Care Utilization
- Ion channel regulation and function
- Pharmacological Effects and Assays
- Bone health and treatments
- Bone Metabolism and Diseases
- Renal function and acid-base balance
- Cardiovascular and Diving-Related Complications
Medical University of Warsaw
2015-2025
Idiopathic nephrotic syndrome (NS) is associated with immune dysfunction and increased susceptibility to infections. Oral health may influence systemic inflammation disease progression. This study aimed evaluate the salivary levels of interleukin-6 (IL-6) interleukin-18 (IL-18) in children NS their association dental health, particularly caries prevalence consequences untreated caries. A cross-sectional was conducted on 86 aged 5–17 years, including 40 patients 46 healthy controls. Clinical...
Background Neutrophil gelatinase‐associated lipocalin (NGAL) is a new useful biomarker for the early diagnosis of acute kidney injury. The aim study was to compare two analytical methods measurement urinary NGAL: enzyme‐linked immunosorbent assay (ELISA) and chemiluminescent microparticle immunoassay (CMIA). Methods Two assays were used measure ELISA kit (R&D Systems) ARCHITECT Urine NGAL (Abbott Laboratories). material urine obtained from 30 healthy subjects (mean age 56.4 ± 15.2)....
Asymmetric dimethylarginine (ADMA) and symmetric (SDMA) are endogenous inhibitors of nitric oxide (NO) synthesis, play a critical role in the process endothelial dysfunction, considered markers oxidative stress. The aim present study was to explore relationships between ADMA and/or SDMA occurrence OSA obese patients as well effect synthase (eNOS) gene polymorphism, which may modify influence or on NO production. A total 518 unrelated subjects were included this study. Body weight, height...
Cloud-point extraction (CPE) is rarely combined with liquid chromatography coupled to mass spectrometry (LC-MS) in drug determination due the matrix effect (ME). However, we have recently shown that ME not a limiting factor CPE. Low efficiency may be improved by salt addition, but none of salts used CPE are suitable for LC-MS. It first time influences volatile salt-ammonium acetate (AA)-on and been studied. Our modification included also use ethanol instead acetonitrile reduce sample...
Acute kidney injury (AKI) is described as a relatively common complication of exercise. In clinical practice the diagnosis AKI based on serum creatinine, level which dependent not only glomerular filtration rate but also muscle mass and injury. Therefore, overestimated after physical The aim this study was to determine changes in uremic toxins: urea, uric acid, asymmetric dimethylarginine (ADMA), symmetric (SDMA), trimethylamine N-oxide (TMAO) urinary makers AKI: albumin, neutrophil...
Background p-Cresol sulfate (pCS) and indoxyl (IS) are uremic toxins, high concentrations of which related to renal failure progression. Saliva could become the first-line diagnostic sample choice, especially for monitoring purposes. Recently, a method determination pCS IS in saliva was developed. Since no data exist on correlations between levels toxins serum, applicability as material is yet be established. Here, we present study assessment utility testing estimation toxin serum. Methods...
The aim of this study was to develop magnetic molecularly imprinted nano-conjugate sorbent for effective dispersive solid phase extraction antazoline (ANT) and its metabolite, hydroxyantazoline (ANT-OH) in analytical method employing liquid chromatography coupled with mass spectrometry method. core–shell material characterized terms adsorption properties, morphology structure. heterogeneous population sites towards ANT-OH by two Kd Bmax values: (1) = 0.319 µg L−1 0.240 μg g−1, (2) 34.6 5.82...
Acute kidney injury (AKI) is a significant risk factor for developing chronic disease and progression to end-stage renal in elderly patients. AKI also relatively common complication after transplantation (KTx) associated with graft failure. Since the lifespan of transplanted limited, loss/deterioration function (DoGF) should be estimated apply preventive treatment. The collection saliva urine more convenient than collecting blood can performed at home. study aimed verify whether non-invasive...
Antazoline (ANT) was recently shown to be an effective and safe antiarrhythmic drug in the termination of atrial fibrillation. However, is still not listed clinical guidelines. No data on ANT metabolism humans available. We used liquid chromatography coupled with tandem mass spectrometry identify characterize metabolites ANT. analyzed plasma volunteers following a single intravenous administration 100 mg mesylate vitro cultures human hepatocytes. revealed that transformed into at least 15 we...
Wiele substancji endogennych oraz egzogennych wykazuje zdolność do wiązania się z białkami osocza, głównie ludzką albuminą surowicy α-1-kwaśną glikoproteiną. Substancje te w krwioobiegu występują zarówno formie wolnej jak i związanej białkami. Białko posiada na swojej powierzchni miejsca charakterystyczne dla danego związku, różniące wielkością, kształtem powinowactwem. Wiązanie następuje wyniku oddziaływań hydrofobowych, van der Waalsa elektrostatycznych. Stopień związania osocza zależy od...
Kidney diseases are characterized by deterioration of the function this organ, often leading to irreversible failure, where transplantation is only alternative permanent dialysis. Proteolytic enzymes, including cathepsins B, cleave peptide bond hydrolysis reaction. They also involved in pathological processes such as carcinogenesis and inflammatory processes. The aim study was determine activity cathepsin B serum patients after kidney assess correlation with glucocorticosteroids treatment.In...
Introduction. The pathogenesis of oral diseases may be associated with oxidative stress. Salivary antioxidant system constitutes one the key salivary defence mechanisms against pathogens and a protective factor for cavity. Aim. To investigate relationship between health (hygiene level, gingival dental health), age gender capacity parameters in children adolescents permanent dentition. Material methods. A total 87 patients were examined. DMFT/DMFS white spot lesions (WSL), hygiene level...
Choroby nerek stanowią wyzwanie dla współczesnej medycyny. Obecnie przewlekła choroba klasyfikowana jest jako „choroba cywilizacyjna”. W związku ze starzeniem się społeczeństwa problem chorób wciąż narasta, ponieważ osoby w wieku podeszłym są grupą szczególnie narażoną na pogorszenie funkcji nerek. Dodatkowo, występowanie współistniejących, takich jak choroby sercowo-naczyniowe, znacząco utrudnia terapię oraz zwiększa śmiertelność chorych. Przewlekła ma charakter postępujący i ostatecznie...