Cytologic screening has been widely used for detecting the cervical cancers. In this study, a semiautomatic PC-based cellular image analysis system was developed segmenting nuclear and cytoplasmic contours computing morphometric textual features to train support vector machine (SVM) classifiers classify four different types of cells discriminate dysplastic from normal cells. A software program incorporating function, including reviewing standardized denomination file names, also designed...

The proper prediction of the location disulfide bridges is efficient in helping to solve protein folding problem.Most previous works on connectivity pattern use prior knowledge bonding state cysteines.The DBCP web server provides without method used this improves accuracy (Q p ) over studies reported literature.

Objective. Few studies have examined the relationship between gout and erectile dysfunction (ED). We investigated whether patients with exhibited an increased risk of ED. Methods. This longitudinal nationwide cohort study incidence ED in 19,368 men who were newly diagnosed January 2002 December 2008. A total 77,472 controls without randomly selected from general population frequency-matched according to age sex. The followed up date on which they included event, censoring, or 31, 2010....

More than 1 billion people suffer from chronic respiratory diseases worldwide, accounting for more 4 million deaths annually. Inhaled corticosteroid is a popular medication treating diseases. Its side effects include decreased bone mineral density and osteoporosis. The aims of this study are to investigate the association inhaled corticosteroids fracture design clinical support system prediction. data patients aged 20 years older, who had visited healthcare centers been prescribed with...

Lack of sleep can compromise the immune system, which may reactivate latent varicella-zoster virus. Studies on disorders and risk herpes zoster (HZ) are scant. We conducted a population-based cohort study to evaluate HZ in patients with potential factors for development. identified without apnea from 2002 2005 by using Taiwan Longitudinal Health Insurance Database. The were randomly selected frequency matched according age, sex, index year. estimated follow-up time person-years entry date...

Erectile dysfunction (ED) affects millions of men worldwide. Men with ED generally complain failure to attain or maintain an adequate erection during sexual activity. The prevalence is strongly correlated age, affecting about 40% at age 40 and nearly 70% 70. A variety chronic diseases, including diabetes, ischemic heart disease, congestive failure, hypertension, depression, renal obstructive sleep apnea, prostate gout, disorder, were reported be associated ED. In this study, data retrieved...

Bronchiectasis is characterized by permanent dilatation of the bronchial tree caused recurrent airway infection and inflammation. The association atherosclerosis inflammation well established. However, studies on relationship between bronchiectasis stroke are scant.We conducted a population-based cohort study to investigate incidence risk ischemic in patients with bronchiectasis.Data 1,295 newly diagnosed as 2000 2008 were retrieved from Taiwan National Health Insurance Research Database. A...

Interstitial cystitis/bladder pain syndrome (IC/BPS) has several well-known comorbid psychiatric manifestations, including insomnia, anxiety, and depression. We hypothesized that somatoform disorder, which is a psychosomatic disease, can be used as sensitive phenotype of IC/BPS. investigated whether disorder increases the risk A nested case-control study retrospective cohort were followed up over 12-year period (2002–2013) in Taiwan Health Insurance Reimbursement Database. In study, 1612...

Few studies have investigated the relationship between sleep disorders (SD) and erectile dysfunction (ED). Therefore, this study explored whether patients with SD in an Asian population are at increased risk of developing ED.This longitudinal nationwide population-based cohort incidence ED 34,548 men newly diagnosed 2002 2008 from National Health Insurance Research Database. A total 138,192 controls without were randomly recruited general frequency matched according to age sex. The follow-up...

A model with capability for precisely predicting readmission is a target being pursued worldwide. The objective of this study to design predictive models using artificial intelligence methods and data retrieved from the National Health Insurance Research Database Taiwan identifying high-risk pneumonia patients 30-day all-cause readmissions. An integrated genetic algorithm (GA) support vector machine (SVM), namely IGS, were used optimized three functions. In GA was selecting salient features...

The main purpose of this study is to develop an APP by integrating GPS provide the digitized information local cultural spots guide tourists for tourism promotion and mountaineering trails monitor energy expenditure (EE) health promotion. provided also adopted educational purpose. Extended Technology Acceptance Model (TAM) was used evaluate usefulness behavior intention functions in developed system. Most users agreed that system useful promotion, folk-culture education. They showed strong...

Objectives Somatic symptoms are somatic complaints accompanied by disproportionate thoughts, feelings, and behaviors related to such symptoms. The study investigated five International Classification of Diseases, Ninth Revision, Clinical Modification diagnoses hallmarked hypothesized an increased risk interstitial cystitis/bladder pain syndrome in patients with Methods raw data were obtained from a nationwide health insurance reimbursement database over 12-year period 2002 2013. followed...

Patient readmission may be attributed to unsuccessful treatments, new diseases, or worsening comorbidities, which manifest degraded healthcare quality and increased cost of a hospital. Clinical decision support systems (CDSSs) provide useful information expert knowledge improve diagnostic performance, treatment outcomes, in clinical settings. The objectives this study is design CDSS based on the data retrieved from National Health Insurance Research Database (NHIRD) for assisting physicians...

Prediction of the protein structure is one most important problems in computational biology, and it remains biggest challenges structural biology. Disulfide bonds play an import role stabilizing conformations. For protein-folding prediction, a correct prediction disulfide bridges can greatly reduce search space. The bonding pattern helps, to certain degree, predicts 3D hence its function since imposes geometrical constraints on backbones. Then, related features called normalized pair...