A5053571182- COVID-19 Impact on Reproduction
- Epigenetics and DNA Methylation
- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Cancer Genomics and Diagnostics
- Neuroblastoma Research and Treatments
- Cancer-related gene regulation
- Bacterial Genetics and Biotechnology
- RNA regulation and disease
- Prenatal Screening and Diagnostics
- Neuroinflammation and Neurodegeneration Mechanisms
- Inflammasome and immune disorders
- DNA Repair Mechanisms
- RNA modifications and cancer
- Genomics and Chromatin Dynamics
Hong Kong University of Science and Technology
2021-2024
University of Hong Kong
2021-2024
Epigenomics (Germany)
2021
SETDB1 is an essential histone methyltransferase that deposits H3 lysine 9 trimethylation (H3K9me3) to transcriptionally repress genes and repetitive elements. The function of differential H3K9me3 enrichment between cell-types remains unclear. Here, we demonstrate mutual exclusivity CTCF across mouse tissues from different developmental timepoints. We analyze depleted cells discover prevents aberrant binding independently DNA methylation H3K9me2. Such sites are enriched with SINE B2...
Abstract The Origin Recognition Complex (ORC) is an evolutionarily conserved six-subunit protein complex that binds specific sites at many locations to coordinately replicate the entire eukaryote genome. Though highly in structure, ORC’s selectivity for replication origins has diverged tremendously between yeasts and humans adapt vastly different life cycles. In this work, we demonstrate determinant of ORC DNA binding lies a 19-amino acid insertion helix Orc4 subunit, which present yeast but...
During pregnancy the maternal-fetal interface plays vital roles in fetal development. Its disruption is frequently found complications. Recent studies show increased incidences of adverse outcomes patients with COVID-19; however, mechanism remains unclear. Here we analysed molecular impacts SARS-CoV-2 infection on interface. Generating bulk and single-nucleus transcriptomic epigenomic profiles from COVID-19 control samples, discovered aberrant immune activation angiogenesis patterns distinct...
Adult-onset neurodegenerative diseases are often accompanied by evidence of a chronic inflammation that includes activation microglial cells and altered levels brain cytokines. Aspects this response likely secondary reactions to neurodegeneration, but for many illnesses the may itself be an early even causative disease event. In such cases, is referred as “sterile” it occurs in absence actual bacterial or viral pathogen. A potent trigger sterile CNS microglia has been shown presence DNA...
Hepatocellular carcinoma (HCC) exhibits widespread epigenetic alterations, yet their impact on cis-regulatory elements (CREs) and retrotransposons remains poorly understood. Here, we present an integrated epigenomic transcriptomic analysis of HCC tumors matched tumor-adjacent normal tissues. We identified extensive DNA hypomethylation coupled with changes in histone modifications at partially methylated domains, CREs, retrotransposons. These aberrations were associated dysregulated...
Abstract During pregnancy, the maternal-fetal interface plays vital roles in fetal development. Its disruption is frequently found pregnancy complications. Recent works show increased incidences of adverse outcomes COVID-19 patients; however, mechanism remains unclear. Here, we analyzed molecular impacts SARS-CoV-2 infection on interface. Generating bulk and single-nucleus transcriptomic epigenomic profiles from patients control samples, discovered aberrant immune activation angiogenesis...