A5044221431- HIV Research and Treatment
- Immune Cell Function and Interaction
- Reproductive System and Pregnancy
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Hepatitis C virus research
- Hepatitis Viruses Studies and Epidemiology
- Diabetes and associated disorders
- Inflammasome and immune disorders
- HIV-related health complications and treatments
- Immunodeficiency and Autoimmune Disorders
- Hepatitis B Virus Studies
- Reproductive tract infections research
- Diverse Scientific Research Studies
National Institute for Research in Reproductive Health
2013-2021
National Institute of Immunohaematology
2020
Indian Council of Medical Research
2015-2018
Background . NK cells have anti-HIV activity mediated through killer cell immunoglobulin-like receptors (KIRs). The current prospective cohort study evaluated whether variation in KIR genes is associated with HIV infection discordant couples (DCs), where one spouse remains seronegative (HSN) despite repeated exposure to the HIV. Methods was genotyped using PCR SSP. Viral load and CD4 counts were estimated commercially available reagents. Data analyzed SPSS software. Results Among 47 DCs, HSN...
Natural killer (NK) cells have antiviral activity mediated through immunoglobulin receptors (KIRs). Studies shown the importance of KIR in HIV infection. However reports on association genes infection from Indian population are limited, not a single study is reported exposed uninfected (EU) and infected infants. This compared gene repertoire HIV-1 positive (n = 29) with EU 76) infants to elucidate its transmission. genotyping was analysed using PCR-SSP method. Viral load mothers, CD4 count...
The pro-inflammatory (Th1) cytokines namely interleukin (IL)-2, IL-6, IL-12, interferon (IFN)-γ, tumor necrosis factor-α (TNF-α) are vital in the clearance of HIV infection. This prospective cohort study aimed to evaluate polymorphisms Th1 cytokine genes and their corresponding plasma levels HIV-1 positive exposed uninfected (EU) infants born mothers. CD4 count, viral load mothers was done using commercially available reagents. Cytokine genotyping analysis were 20 54 EU infants. PCR-SSP...
Abstract Background Vertical HIV transmission does not occur in all exposed infants. Many infants remain uninfected even after exposure. This is partly attributed to the host genes involving cytokine production, which rarely documented vertical transmission. Methods Here, an observational cohort study evaluated whether polymorphisms cytokine, receptor and antagonist are associated with perinatal Single nucleotide polymorphism (SNP) genotyping was performed via polymerase chain reaction...
HIV pathogenesis is known to be highly influenced by host genetic factors, such as human leucocyte antigens (HLAs) HLA-A and HLA-B. However, the role of HLA-C remains largely unexplored. We evaluated distribution in 186 HIV-1-infected individuals compared them ethnically matched data derived from Allele Frequency Net Database using Chi-square test with Fisher’s exact two-tailed test. The frequency HLA-C*05 HLA-C*15 was higher infected group, whereas HLA-C*04 HLA-C*14 control group. HLA-C*17,...
Hepatitis-B is a health problem of global importance. India falls in the low intermediate endemicity zone (prevalence rate 2-4%) for hepatitis-B virus infection. Intrafamilial transmission HBV has an important role maintaining our country. Here we report interesting case intrafamilial clustering infection from western India. Out 14 family members, 12 members (85.7%) were infected (overt or occult). This highlights that vertical also route transmission. Screening and contacts HBsAg positive...
Background Human leukocyte antigens (HLA) an important host genetic factor is responsible for influencing human immunodeficiency virus/acquired syndrome (HIV/AIDS) transmission and disease progression. Contributions of HLA I II alleles have not been reported in the Indian population with respect to vertical HIV transmission. Aim In current study we determined frequencies class a cohort children exposed through their mothers. Method this exploratory perinatally HIV-1 who fit criteria had...