A5025650071- Analytical chemistry methods development
- Water Quality Monitoring and Analysis
- Pesticide Residue Analysis and Safety
- Electrochemical Analysis and Applications
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Analytical Chemistry and Sensors
- Analytical Chemistry and Chromatography
- Pharmaceutical and Antibiotic Environmental Impacts
- Laser-induced spectroscopy and plasma
- Molecular Sensors and Ion Detection
- Spectroscopy and Chemometric Analyses
- Coal and Its By-products
- Mass Spectrometry Techniques and Applications
- Virus-based gene therapy research
- DNA and Nucleic Acid Chemistry
- Advanced Chemical Sensor Technologies
- Radiation Effects and Dosimetry
- Water Quality and Pollution Assessment
- Heavy metals in environment
- Lipid Membrane Structure and Behavior
- Surfactants and Colloidal Systems
- Pesticide Exposure and Toxicity
- Effects and risks of endocrine disrupting chemicals
- Pesticide and Herbicide Environmental Studies
Université Européenne de Bretagne
2010-2024
Université de Bretagne Occidentale
2012-2024
Tsinghua University
2023-2024
Laboratoire des Sciences et Techniques de l’Information de la Communication et de la Connaissance
1998-2023
Université du littoral côte d'opale
2022
Université Alioune Diop de Bambey
2022
Laboratoire Chimie Electrochimie Moléculaires et Chimie Analytique
1998-2016
Centre National de la Recherche Scientifique
2002-2015
Inserm
2007
Département de Chimie Moléculaire
2000
Cationic lipophosphoramidates constitute a class of cationic lipids we have previously reported to be efficient for gene transfection. Here, synthesized and studied novel lipophosphoramidate derivative characterized by an arsonium headgroup linked, via phosphoramidate linker, unconventional lipidic moiety consisting two diunsaturated linoleic chains. Physicochemical studies allowed us comparatively evaluate the specific fluidity fusogenicity properties liposomes formed. Although...
The DNA compacting properties of polyamines (especially spermine) are well-known, hence the use spermine as cationic part in several synthetic carriers. Here, we describe synthesis modified spermines, with a "lipophosphoramidate" lipidic part, and their for efficient vitro transfection. Physicochemical measurements (particle size, zeta potentials, pKa determination) gel retardation assays were also performed. Theoretical membrane-disrupting ability was established by FRET. Taken together,...
The synthesis of cationic lipo-thiophosphoramidates, a new family lipids designed for gene delivery, is reported herein. This class less polar than its oxygenated equivalent the lipo-phosphoramidates. Fluorescence anisotropy and FRET were used to determine fluidity fusogenicity lipo-phosphoramidates 3a-b lipo-thiophosphoramidates 7a-b. determination both size zeta potential nano-objects (liposomes lipoplexes) DNA binding ability liposomes have completed physico-chemical characterizations...
Flumethrin and tau-fluvalinate pyrethroid insecticides were determined in natural water using photochemically induced fluorescence (PIF). As these pesticides are not naturally fluorescent, PIF ultraviolet irradiation was employed to produce highly fluorescent derivatives. This method optimized for interval, solvent pH. The calibration curves linear with limits of detection (LOD) from 0.5 73.8 ng mL−1 without matrix effects. Applications carried out aqueous solutions on tap water, seawater,...
Tau -fluvalinate and inclusion example in β-cyclodextrin.
A new method was developed for determining trace amounts of pesticides, using an ultraviolet (UV) lamp to obtain photo-induced fluorescent (PIF) compounds, and then laser excitation (LE) by a tunable source excite simultaneously characterize their fluorescence over short acquisition time intensified charge-coupled device camera. This UV-PIF-LE applied determine isoproturon, oxadiazon, fipronil in natural waters. approach represents improvement on the previously published direct (DL-PIF) that...
To detect irradiated foodstuffs, we used the Nawar relation between lipid structure and radiolysis compounds, such as alkanes alkenes. We first applied this method to sunflower, olive peanut oils. Alkanes alkenes were analyzed by gas chromatography with a head‐space system for desorption concentration of volatile compounds. The detection limit, obtained both estimation chromatogram area blind trial, is better than 0.15 kGy. continuity storage time was also studied. have compared these...
Abstract Diflubenzuron (DFB) and fenuron (FEN) are benzoylurea phenylurea pesticides, widely used in Senegal, that do not exhibit any natural fluorescence, but can be determined by means of photoinduced fluorescence (PIF) methods. Photodegradation DFB FEN yielded a number fluorescent non‐fluorescent photoproducts. For both at least 10 photoproducts were detected identified gas chromatography–mass spectrometry (GC/MS). To identify the formed photoproducts, their spectra compared with those...
Abstract Fluorescent amphiphilic phospholipids (neutral or cationic) in which fluorescent probes are contained the lipid domain were synthesized via phosphoramide intermediates possessing two distinct chains. One of these chains is ω‐functionalized with an azide alkyne group, and this subsequently used to introduce a probe by Huisgen cycloaddition. Five different (naphthalimide, dansyl, fluoresceine, Nile red, coumarin) considered study. These neutral cationic lipids included at 1 % molar...