A5032096385- Fungal Biology and Applications
- Herbal Medicine Research Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Medicinal Plants and Bioactive Compounds
- High Altitude and Hypoxia
- Biomedical Text Mining and Ontologies
- AI in cancer detection
- Pulmonary Hypertension Research and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Neurobiology and Insect Physiology Research
- Cancer, Hypoxia, and Metabolism
- Phytochemicals and Antioxidant Activities
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Radiomics and Machine Learning in Medical Imaging
Institute of Genomics and Integrative Biology
2024
Symbiosis International University
2024
Defence Institute of Physiology and Allied Sciences
2012-2022
Ministry of Defence
2015-2022
Exposure to high altitude induces physiological responses due hypoxia. Lungs being at the first level face alterations in oxygen levels are critical counter and balance these changes. Studies have been done analysing pulmonary proteome response exposure hypobaric However, such studies reported specific time points do not reflect gradual proteomic These also identify various biochemical pathways induced after immediate resolution of effects challenge In present study, using 2-DE/MS approach,...
Abstract INPP4A has been shown to be involved in the regulation of cell proliferation and apoptosis multiple types including fibroblasts. Previous reports from our group have demonstrated role inositol polyphosphate 4‐phosphatase Type I A (INPP4A) these functions. Though existing evidences suggest a critical for maintenance lung homeostasis, its chronic diseases is relatively under explored. In current study, we made an attempt understand idiopathic pulmonary fibrosis (IPF). Through...
Abstract Background The tissue-specific Unigene Sets derived from more than one million expressed sequence tags (ESTs) in the NCBI, GenBank database offers a platform for identifying significantly and differentially genes by in-silico methods. Digital differential display (DDD) rapidly creates transcription profiles based on EST comparisons numerically calculates, as fraction of pool ESTs, relative abundance known novel genes. However, process most likely tissue specific disease which to...
The current study presents application of chemometrics to high performance thin layer chromatography (HPTLC) fingerprints Indian medicinal mushrooms, Cordyceps sinensis (CS) and Ganoderma lucidum (GL). These mushrooms possess numerous bio-active constituents that endow them with several properties. Five CS extracts using different compositions water ethanol nine sequentially extracted GL were prepared employing the accelerated solvent extraction technique. A rapid convenient HPTLC method was...
Oriental medicinal mushroom Ganoderma lucidum has been widely used for the promotion of health and longevity owing to its various bioactive constituents. Therefore, comprehending metabolomics different G. parts could be paramount importance investigating their pharmacological properties. Ultra-performance convergence chromatography (UPC2) along with mass spectrometry (MS) is an emerging technique that not yet applied metabolite profiling lucidum. This study undertaken establish aqueous...
This study demonstrated the protective efficiency of extracts Indian variety Ophiocordyceps sinensis (=Cordyceps sinensis) (CSEs) in HT22 (murine hippocampal) cells under hypoxic conditions. Various parameters such as cell viability, reactive oxygen species, levels endogenous antioxidants, inflammatory cytokines, transcription factors, and oxidation macromolecules were analyzed. In addition, radical scavenging abilities hydroxyl radicals, nitric oxide, superoxide radicals also studied....