A5000109296- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- Head and Neck Cancer Studies
- Sleep and related disorders
- Respiratory Support and Mechanisms
- Hearing Loss and Rehabilitation
- Tracheal and airway disorders
- Voice and Speech Disorders
- Dysphagia Assessment and Management
- Nasal Surgery and Airway Studies
- Reconstructive Surgery and Microvascular Techniques
- Ear Surgery and Otitis Media
- Global Healthcare and Medical Tourism
- Esophageal Cancer Research and Treatment
- Neonatal Respiratory Health Research
- Airway Management and Intubation Techniques
- Management of metastatic bone disease
- Diversity and Career in Medicine
- Circadian rhythm and melatonin
- Sinusitis and nasal conditions
- Salivary Gland Tumors Diagnosis and Treatment
- Gastroesophageal reflux and treatments
- Head and Neck Surgical Oncology
- Cardiovascular and Diving-Related Complications
Harvard University
2018-2025
Massachusetts Eye and Ear Infirmary
2018-2025
Brigham and Women's Hospital
2019-2024
Circadian (United States)
2022-2024
Yale University
2017-2019
VA Connecticut Healthcare System
2019
Yale Cancer Center
2019
Patients with Down syndrome have a high incidence of persistent obstructive sleep apnea (OSA) and limited treatment options. Upper airway hypoglossal stimulation has been shown to be effective for adults OSA but not yet evaluated pediatric populations.
Obstructive sleep apnea is associated with neurobehavioral dysfunction, but the relationship between disease severity as measured by apnea-hypopnea index and morbidity unclear. The objective of our study to compare mild sleep-disordered breathing versus obstructive apnea.Children 3-12 years old recruited for (snoring index<3) into Pediatric Adenotonsillectomy Trial Snoring were compared children 5-9 (obstructive 2-30) Childhood Trial. Baseline demographic, polysomnographic, outcomes using...
BACKGROUND The growing epidemic of human papillomavirus‐positive (HPV+) oropharyngeal cancer and the favorable prognosis this disease etiology have led to a call for deintensified treatment some patients with HPV+ cancers. One proposed methods deintensification is avoidance chemotherapy concurrent definitive/adjuvant radiotherapy. To authors' knowledge, safety form de‐escalation unknown current literature in area sparse. authors investigated outcomes after various combinations stratified by...
Though described as an important prognostic indicator, facility case volume thresholds for patients with head and neck squamous cell carcinoma (HNSCC) have not been previously developed to date.To identify of facilities that manage HNSCC.Retrospective analysis 351 052 HNSCC cases reported from January 1, 2004, through December 31, 2014, by Commission Cancer-accredited cancer centers the US National Cancer Database. Data were analyzed August 2018, April 5, 2019.Treatment at varying...
Importance The literature indicates that health care utilization (HCU) of children with untreated moderate-to-severe obstructive sleep apnea is greater than matched controls before diagnosis, and treatment associated a decline in HCU not observed those who remain untreated. Research on this topic has been limited to retrospective analyses observational cohort studies; little known about among the many snoring mild sleep-disordered breathing (SDB). Objective To determine whether...
ABSTRACT Objectives To assess the impact of connected sleep remote on early adherence to therapy with hypoglossal nerve stimulation therapy. Methods Prospective cohort study. Objective data was extracted from a cloud‐based database consecutive patients undergoing implantation unilateral before and after introduction remote. Results We identified 121 original 126 in 12 months remote, respectively. Overall usage first 7 days 7.9 h, used 95.3% nights 0.6 pauses per night. Usage 30 7.7 94.0% h...
Subscription RequiredScientific InvestigationsComparison of clinical pathways for hypoglossal nerve stimulation management: in-laboratory titration polysomnography versus home-based efficacy sleep testing David Kent, MD, Phillip Huyett, Phoebe Yu, MPH, Asim Roy, Reena Mehra, MS, Jessica Vensel Rundo, Stephanie Stahl, Shalini Manchanda, MD Vanderbilt University Medical Center, Nashville, TN , Massachusetts Eye & Ear, Boston MA MPH Ohio Sleep Medicine Institute, Columbus, OH MS Cleveland...
The need for intensive care unit (ICU) admission and mechanical ventilation after head neck microvascular free flap reconstructive surgery remains controversial. Our institution has maintained a longstanding practice of immediately taking patients off with subsequent transfer to intermediate, non-ICU level specialized otolaryngologic nursing. objective was describe postoperative outcomes large cohort undergoing this protocol examine the routine ICU transfer.We performed retrospective review...
Importance: Functional septorhinoplasty (FSRP) has been shown to improve both global and disease-specific quality of life (QOL). However, the mechanism by which FSRP improves QOL not fully defined. We reasoned that NAO may impact sleep and, therefore, studied relationship using validated patient-reported outcome measures. Objective: To investigate correlation between Nasal Obstruction Symptom Evaluation (NOSE) Outcomes Sleep Quality (FOSQ-10) questionnaires, evaluate effect on quality....
Objectives/Hypothesis Patients with Down syndrome have a high incidence of obstructive sleep apnea (OSA) and limited treatment options. Hypoglossal stimulation has shown efficacy but not yet been approved for pediatric populations. Our objective is to characterize the therapy response adolescent patients down severe OSA who underwent hypoglossal stimulation. Study Design Prospective longitudinal trial. Methods We are conducting multicenter single‐arm trial OSA. Interim analysis was performed...
Introduction Mild sleep-disordered breathing (mSDB) in children is associated with both neurobehavioral morbidity and reduced quality of life (QOL). However, the association between symptom burden QOL executive function not well understood, it known whether may help identify neurocognitive dysfunction. Objective To assess associations among function, QOL, mSDB. Design, Setting, Participants This cross-sectional study was a secondary analysis multicenter Pediatric Adenotonsillectomy Trial for...
Using health utility values (HUVs) as an outcome measure for surgical procedures, including rhinoplasty, allows a standardized measurement of the qualitative and financial benefit that procedure on overall health.To use Euroqol 5-Dimension (EQ-5D)-derived HUVs to evaluate nasal obstruction outcomes following surgery between primary rhinoplasty (PSRP) with previous (RNS) in prospective cohort study.A single-institution study 2013 2017 was carried out 185 patients who underwent RNS before...
Abstract Objective Caregivers frequently report poor quality of life (QOL) in children with sleep‐disordered breathing (SDB). Our objective is to assess the correlation between caregiver‐ and child‐reported QOL mild SDB identify factors associated differences caregiver child report. Study Design Analysis baseline data from a multi‐institutional randomized trial Setting Pediatric Adenotonsillectomy Trial for Snoring, where (obstructive apnea‐hypopnea index <3) were observation or...
Extracapsular extension (ECE) is a well-established prognostic feature in squamous cell cancers of the head and neck. Although some extrapolate data from mucosal neck cancer to include ECE as high-risk salivary gland cancers, lacking about ECE's value for these malignancies. We investigate whether significant indicator pathologic node-positive major glands.A retrospective study adult cases diagnosed 2004 2013 NCDB was conducted. Demographic, tumor, treatment, survival variables were included...
Objective Sleep medicine is a multidisciplinary field that includes otolaryngology. After 2011, sleep board eligibility required completion of dedicated fellowship. The objective our study to describe the characteristics and geographic distribution dual board‐certified otolaryngology workforce assess impact 2011 change. Methods A cross‐sectional analysis sleep‐certified otolaryngologists registered with American Board Otolaryngology‐Head Neck Surgery in 2019 was performed characterize...
Background: Increased body mass index (BMI) has been associated with postoperative complications in multiple surgical specialties. In otologic surgery involving the stapes, where appropriate patient positioning and dexterity are necessary for proper prosthesis placement, patients higher BMI could make more challenging. The purpose of this study is to evaluate impact on outcomes after stapes surgery. Methods: Medical records were examined from January 2015 December 2017 undergoing...
Patients with obstructive sleep apnea (OSA) are at an increased risk for perioperative cardiopulmonary complications. Our objective was to assess the postoperative effects of hypoglossal nerve stimulation implantation (HGNS) and expansion pharyngoplasty (EP) on longitudinal measures as a surrogate respiratory
Hypoglossal nerve stimulation (HGNS) is an implantable therapy for obstructive sleep apnea (OSA). Therapy efficacy currently confirmed by a formal study after empiric adjustment the patient at home based on their subjective experience with device. Home-based longitudinal hypopnea index (AHI) measurements have potential to refine HGNS therapeutic amplitude selection objective data. Our was compare AHI derived from routine studies and two different devices in new recipients.