A5045635107- Nasal Surgery and Airway Studies
- interferon and immune responses
- Cancer Genomics and Diagnostics
- Facial Nerve Paralysis Treatment and Research
- Cell death mechanisms and regulation
- Facial Rejuvenation and Surgery Techniques
- Spine and Intervertebral Disc Pathology
- RNA modifications and cancer
- Reconstructive Facial Surgery Techniques
- Spinal Fractures and Fixation Techniques
- Cancer-related Molecular Pathways
- Ubiquitin and proteasome pathways
- Digital Imaging in Medicine
- Obstructive Sleep Apnea Research
- Circular RNAs in diseases
- Cleft Lip and Palate Research
- Musculoskeletal pain and rehabilitation
- Hair Growth and Disorders
- Facial Trauma and Fracture Management
- Head and Neck Cancer Studies
- Cervical and Thoracic Myelopathy
- Craniofacial Disorders and Treatments
- Bone fractures and treatments
- Viral Infections and Outbreaks Research
- Cancer Cells and Metastasis
Loma Linda University
2023-2025
Loma Linda University Medical Center
2025
Harvard University
2019-2023
Massachusetts Eye and Ear Infirmary
2019-2023
National Institute on Deafness and Other Communication Disorders
2016-2023
National Institutes of Health
2016-2023
Johns Hopkins University
2022
Centre Hospitalier Universitaire Sainte-Justine
2020
Université de Montréal
2020
Cleveland Clinic Lerner College of Medicine
2013-2020
Study Design: A multicenter, retrospective review of C5 palsy after cervical spine surgery. Objective: Postoperative is a known complication decompressive spinal The goal this study was to the incidence, patient characteristics, and outcome in patients undergoing Methods: We conducted 13 946 across 21 centers who received surgery (levels C2 C7) between January 1, 2005, December 31, 2011, inclusive. P values were calculated using 2-sample t test for continuous variables χ 2 tests or Fisher...
Comparison of tumors from The Cancer Genome Atlas (TCGA) reveals that head and neck squamous cell carcinomas (HNSCC) harbor the most frequent genomic amplifications Fas-associated death domain (FADD), with or without Baculovirus inhibitor apoptosis repeat containing BIRC2 (cIAP1), affecting about 30% patients in association worse prognosis. Here, we identified HNSCC lines harboring FADD/BIRC2 overexpression by exome sequencing, RT-PCR, Western blotting. In vitro, FADD siRNA knockdown...
Objectives The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) established a standardized, tiered reporting system salivary gland fine‐needle aspiration (FNA) that has gained international acceptance among cytologists. Our goal was to review the key features of MSRSGC familiarize surgical community with this and its application FNA evaluation masses. Methods A comprehensive in clinical practice. Results consists six major diagnostic categories: 1) nondiagnostic, 2)...
Background: Gender-affirming surgery may be pursued by individuals experiencing gender dysphoria. Although genital and chest procedures are classified as medically necessary, facial feminization surgeries (FFSs) often considered cosmetic. Insurance companies limit coverage of these procedures, especially in states less supportive transgender individuals. Objectives: To determine insurance ease finding policy information for FFSs, to analyze differences based on state advocacy. Methods:...
Abstract Purpose: Human papillomavirus–negative (HPV−) head and neck squamous cell carcinomas (HNSCC) harbor frequent genomic amplification of Fas-associated death domain, with or without concurrent Baculovirus inhibitor apoptosis repeat containing (BIRC2/3) genes encoding cellular proteins 1/2 (cIAP1/2). Antagonists targeting cIAP1 have been reported to enhance sensitivity HPV−, but not HPV+ tumors, TNF family ligands (TNF TRAIL) radiation. Experimental Design: We tested a novel dual...
Background: Nonflaccid facial palsy is a debilitating entity characterized by hypertonicity, synkinesis, and hypomobility. Patients with nonflaccid often have smile asymmetry restriction because of disruption normal vector forces on the modiolus. Excision depressor anguli oris can lead to improved oral commissure excursion, angle, dental show, symmetry. Methods: All resection cases between January 8, 2018, December 26, 2019, were reviewed. postoperative photographs included in this cohort...
Few studies have examined the general correlation between socioeconomic status and imaging. This study is first to analyze this relationship in spine patient population.To assess effect of on frequency with which imaging lumbar are ordered completed.Patients that were diagnosed radiculopathy and/or myelopathy had at least 1 subsequent magnetic resonance (MRI), computed tomography (CT), or X-ray retrospectively identified. Demographic information number completed among data collected. Patient...
Purpose of review Wounds within the face, head, and neck region can have devastating aesthetic, functional, potentially fatal outcomes for patients often require multimodality treatment. Here we discuss role hyperbaric oxygen a variety wounds head clinically associated outcomes. Recent findings Hyperbaric (HBO) treatment be useful in management infections region. While there are few randomized controlled clinical trials evaluating effectiveness HBO therapy, is large amount retrospective...
Purpose of review To the utility negative pressure wound therapy (NPWT) in management head and neck wounds. Recent findings NPWT has broad applications demonstrated success treatment fistulas necrotizing soft tissue infections. Immediate application after free flap reconstruction is also shown to be safe, with benefits reduced edema promotion healing. can further used prepare chronic wounds for reconstruction, particularly patients who have undergone radiotherapy. The addition intermittent...
The reaction of the methylidyne radical (CH) with acetone ((CH3)2CO) is studied at room temperature and a pressure 4 Torr (533.3 Pa) using multiplexed photoionization mass spectrometer coupled to tunable vacuum ultraviolet synchrotron radiation Advanced Light Source Lawrence Berkeley National Laboratory. CH radicals are generated by 248 nm multiphoton photolysis bromoform react in an excess helium nitrogen gas flow. main observed exit channel elimination hydrogen atom form C4H6O isomers....
Multicenter retrospective case series. To determine the rate of thoracic duct injury during cervical spine operations. A series study was conducted among 21 high-volume surgical centers to identify instances anterior surgery. Staff at each center abstracted data for identified into report forms. All forms were collected by AOSpine North America Clinical Research Network Methodological Core processing, cleaning, and analysis. Of a total 9591 patients reviewed that underwent surgery, 2 (0.02%)...
A retrospective 1-year cost-utility analysis.To determine the cost-effectiveness of using recombinant human bone morphogenic protein (rhBMP-2) in addition to autograft for 1- and 2-level lumbar fusions.rhBMP-2 has been studied extensively identify its benefits, risks, patient outcomes, costs relative [local or iliac crest graft (ICBG)]. This study seeks analyze adding rhBMP-2 versus without fusions.Thirty-three patients receiving either local ICBG (rhBMP-2 cohort) 42 only (control dorsal...
Background: In the care of facial paralysis (FP) patient, outcomes have historically focused on function rather than psychosocial burden disease state. Yet, FP patients often describe impact their domains health. These patient concerns motivated clinicians to formally recognize and treat nonfunctional sequelae disease. Dermal filler therapy (DFT) is a minimally invasive reversible procedure that can be used asymmetry improve well-being in patients. However, there are no data describing DFT...
Circulating tumor cells have emerged as prognostic biomarkers in the treatment of metastatic cancers epithelial origins viz., breast, colorectal and prostate. These tumors express Epithelial Cell Adhesion Molecule (EpCAM) on their cell surface which is used an antigen for immunoaffinity capture. However, EpCAM capture technologies are limited utility non-epithelial such melanoma. We report a method to enrich Melanoma Cells (CMCs) that does not presuppose malignant characteristics. CMCs were...
Study Design. A consecutive retrospective cohort study from 2008 to 2013 at a single tertiary-care institution was conducted. Objective. The aim of the characterize recovery pain and neurologic deficit after surgery for vertebral osteomyelitis (VO), identify incidence postoperative adverse events. Summary Background Data. minority patients with VO require surgery. Although prior studies have characterized outcomes medical management, morbidity is poorly defined. Methods. primary outcome...