A5001115106- Mitochondrial Function and Pathology
- Histone Deacetylase Inhibitors Research
- ATP Synthase and ATPases Research
- Cellular transport and secretion
- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- Calcium signaling and nucleotide metabolism
- Autophagy in Disease and Therapy
- Protein Structure and Dynamics
Instituto de Investigaciones Químicas
2022-2024
Centro de Investigaciones Científicas Isla de la Cartuja
2022-2024
Universidad de Sevilla
2024
Abstract Post‐translational modifications (PTMs) of proteins are ubiquitous processes present in all life kingdoms, involved the regulation protein stability, subcellular location and activity. In this context, cytochrome c (C ) is an excellent case study to analyze structural functional changes induced by PTMS as C a small, moonlighting playing different roles cell compartments at cell‐cycle stages. actually key component mitochondrial electron transport chain (ETC) under homeostatic...
The human microbiota plays an important role in health and disease, through the secretion of metabolites that regulate key biological functions. We propose represent unexplored chemical space small drug-like molecules search new hits for drug discovery. Here, we describe generation a set complex chemotypes inspired on selected metabolites, which have been synthesized using asymmetric organocatalytic reactions. Following primary screening CSC models, identified novel compound UCM-13369 (4b)...
Mitochondria play crucial roles as both the powerhouse and signaling center of cells, balancing cell survival death to maintain homeostasis. Disruption this balance can lead various diseases. Therefore, exploring components involved in mitochondrial metabolism presents a significant challenge. In context, respiratory supercomplexes are evolutionarily conserved, stable associations between membrane complexes molecules, including proteins lipids, within inner membrane. These dynamically...