A5044652692- Syphilis Diagnosis and Treatment
- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Cardiac, Anesthesia and Surgical Outcomes
- Blood disorders and treatments
- Infective Endocarditis Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Esophageal and GI Pathology
- Clinical Nutrition and Gastroenterology
- Blood transfusion and management
- Heart Rate Variability and Autonomic Control
- Pancreatitis Pathology and Treatment
- Esophageal Cancer Research and Treatment
- Hemoglobinopathies and Related Disorders
- Autoimmune and Inflammatory Disorders
- Gastroesophageal reflux and treatments
- Reproductive tract infections research
- Poisoning and overdose treatments
- Drug-Induced Hepatotoxicity and Protection
- Anesthesia and Pain Management
- Cardiac Imaging and Diagnostics
- Gastric Cancer Management and Outcomes
- Drug-Induced Adverse Reactions
- Dysphagia Assessment and Management
The University of Texas Medical Branch at Galveston
2019-2023
Brigham and Women's Hospital
2023
Galveston College
2018-2023
University of Haifa
2022
Swedish Medical Center
2016-2020
Society of Thoracic Surgeons
2018
Hadassah Medical Center
2016
Rutgers, The State University of New Jersey
2010-2014
Rutgers New Jersey Medical School
2010-2012
Tel Aviv University
2004
Gut barrier failure has been implicated in the progression from single-organ injury to multiple-organ failure. The unstirred mucus layer is a major component of physiological gut barrier; its role acute pancreatitis (AP) not clearly defined. Rats underwent biliopancreatic duct ligation-induced AP; two controls were used: ligation with drainage and sham ligation. After 4.5 h, serum ascitic amylase activity was measured. Mucus analyzed for reactive nitrogen intermediate-mediated damage, oxygen...
In Brief Objective: To test whether the mucus layer, luminal digestive enzymes, and intestinal mast cells are critical components in pathogenesis of trauma shock–induced gut lung injury. Background: Gut origin sepsis studies have highlighted importance systemic component (ischemia-reperfusion) injury, whereas intraluminal is less well studied. Methods: rats subjected to hemorrhagic shock (T/HS) or sham shock, role pancreatic enzymes injury was tested by diversion via duct exteriorization...
We tested if vagus nerve stimulation (VNS) would prevent gut injury, mesenteric lymph toxicity, and systemic multiple organ dysfunction syndrome following trauma-hemorrhagic shock (T/HS). Four groups of experiments were performed. The first whether VNS (5 V for 10 min) protect against T/HS-induced increases in lung permeability as well neutrophil priming. In the second experiment, was collected from rats subjected to T/HS or trauma-sham with without then injected into naive mice assess its...
Abstract A standard therapy used today for prostate cancer is androgen ablation by gonadotropin-releasing hormone analogs (GnRH-a). Although most patients respond to as an initial systemic therapy, nearly all cases will develop resistance, the management of which still a major challenge. Here, we report that GnRH-a can directly induce apoptosis androgen-independent cancer-derived DU145 and PC3 cell lines. Using specific inhibitors, found apoptotic effect mediated c-Jun NH2-terminal kinase...
Recent studies demonstrate that mechanisms underlying gut barrier failure include systemic processes and less studied luminal processes. We thus tested the hypothesis mucus layer oxidation is a component of trauma/hemorrhagic shock-induced injury dysfunction. Male Sprague-Dawley rats underwent shock. Controls trauma only. Mucus from terminal 30 cm ileum was collected, processed, analyzed for reactive nitrogen intermediates (RNI)-mediated damage, oxygen species (ROS)-induced total antioxidant...
BACKGROUND Hemorrhagic shock is known to disrupt the gut barrier leading end-organ dysfunction. The vagus nerve can inhibit detrimental immune responses that contribute organ damage in hemorrhagic shock. Therefore, we explored whether stimulation of protect and recover lung permeability trauma-hemorrhagic (THS). METHODS Male Sprague-Dawley rats were subjected left cervical at 5 V for 10 minutes. right internal jugular femoral artery cannulated blood withdrawal pressure monitoring,...
Purpose: Retinitis pigmentosa (RP) is a group of clinically and genetically heterogeneous hereditary retinal diseases that result in blindness due to photoreceptor degeneration. Mutations the rhodopsin (RHO) gene are most common cause autosomal dominant RP (adRP) responsible for 16% 35% adRP cases Western population. Our purpose was investigate contribution RHO Israeli Palestinian populations. Methods: Thirty-two families participated study. Mutation detection performed by whole exome...
The efficacy of plasma exchanges (PE) during the course scleroderma has only been investigated for short periods. aim this study was to follow patients over a long enough period observe clinical and paraclinical symptoms in short, medium, term. Forty patients, 24 women 16 men, were treated by PE observed 1–3, 3–12 12 months. Immunological, biological any undesirable side effects evaluated using detailed questionnaire. Concomitant therapies reported most frequently consisted corticosteroids,...
Return of circuit blood after discontinuing extracorporeal membrane oxygenation (ECMO) is an important conservation strategy for reducing the need transfusion. This follows current standard salvaging cardiopulmonary bypass (CPB). There a variety strategies and techniques salvage described associated with CPB but not ECMO. We describe simplified technique to in ECMO that requires no special equipment, safe, maximizes salvage.