A5108036290- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Porphyrin and Phthalocyanine Chemistry
- Photodynamic Therapy Research Studies
- Synthesis and biological activity
- Quinazolinone synthesis and applications
- Crystallography and molecular interactions
- Luminescence and Fluorescent Materials
- Synthesis and Characterization of Heterocyclic Compounds
- Phenothiazines and Benzothiazines Synthesis and Activities
- Photochemistry and Electron Transfer Studies
- Synthesis and Biological Evaluation
- Lanthanide and Transition Metal Complexes
- Metal complexes synthesis and properties
- Free Radicals and Antioxidants
- Microwave-Assisted Synthesis and Applications
Babeș-Bolyai University
2007-2024
Newly synthesized 2-(2-((1H-indol-5yl)methylene)-hydrazinyl)-thiazole derivatives were evaluated for their in vitro cytotoxicity on two carcinoma cell lines A2780 and HeLa. Significant cytotoxic activity 2-(2-((1H-indol-5-yl)methylene)hydrazinyl)-4-methylthiazole (1) 2-(2-((1H-indol-5-yl)methylene)hydrazinyl)-4-phenylthiazole (3), both [IC50: 11.6 μM (1), 12.4 (3)] HeLa 22.4 19.4μM is reported. Their antioxidant potential was by spectrophotometric method, using DPPH radical or Fe (TPTZ)3+...
New and known arylidene-hydrazinyl-thiazole derivatives have been synthesized by a convenient Hantzsch condensation. All compounds were evaluated for their in vitro cytotoxicity on two carcinoma cell lines, MDA-MB231 HeLa. Significant antiproliferative activity 2-(2-benzyliden-hydrazinyl)-4-methylthiazole both MDA-MB-231 (IC50: 3.92 µg/mL) HeLa 11.4 2-[2-(4-methoxybenzylidene) hydrazinyl]-4-phenylthiazole 11.1 line is reported. Electrophoresis experiments showed no plasmid DNA (pTZ57R)...
Application of a dynamic microwave power system in the chemical synthesis ofsome phenothiazine and quinoline derivatives is described. Heterocyclic ring formation,aromatic nucleophilic substitution heterocyclic aldehydes/ketones condensationreactions were performed on solid support, or under solvent free reaction conditions. Themicrowave-assisted Duff formylation was achieved. Comparison ofmicrowave-assisted with conventional synthetic methods demonstratesadvantages related to shorter times...
The molecular frame of the reported series new polyheterocyclic compounds was intended to combine potent phenothiazine and benzothiazole pharmacophoric units. synthetic strategy applied based on oxidative cyclization N-(phenothiazin-3-yl)-thioamides it validated by preparation 2-alkyl- 2-aryl-thiazolo[5,4-b]phenothiazine derivatives. Optical properties were experimentally emphasized UV-Vis absorption/emission spectroscopy structural features theoretically modelled using density functional...
We report here the synthetic procedure applied for preparation of new AB3-type and trans-A2B2 type meso-halogenophenothiazinyl-phenyl-porphyrin derivatives, their metal core complexation peripheral modification using Suzuki–Miyaura cross coupling reactions with various (hetero)aryl (phenothiazinyl, 7-formyl-phenothiazinyl, (9-carbazolyl)-phenyl 4-formyl-phenyl, phenyl) boronic acid derivatives. The meso-phenothiazinyl-phenyl-porphyrin (MPP) dyes family was thus extended by a series novel...
Synthesis, structural characterization and photophysical properties for a series of new trans-A2B2- A3B-type ethynyl functionalized meso-phenothiazinyl-phenyl porphyrin derivatives are described. The compounds displayed the characteristic absorption spectra slightly modified by weak auxochromic effects substituents fluorescence emission in range 651–659 nm with 11–25% quantum yields. changes recorded UV-vis presence trifluoroacetic acid (TFA) consistent protonation two internal nitrogen...
New meso -substituted AB 3 -type phenothiazinyl porphyrins and ferrocenylvinyl porphyrin were synthesised by Suzuki–Miyaura Mizoroki–Heck cross-coupling reactions, respectively.
Monocationic arene ruthenium complexes (RuL1–RuL4) incorporating phenothiazinyl-hydrazinyl-thiazole ligands (L1–L4) have been synthesized, characterized and evaluated as anticancer agents. Their cytotoxicity, antiproliferative activity alteration of apoptotic gene expression were studied on three cancer cell lines, a double positive breast line MCF-7 two triple negative lines Hs578T MDA-MB-231. All able to reduce the viability with highest cytotoxicities being recorded for...