A5101645149- Healthcare and Venom Research
- Autophagy in Disease and Therapy
- Acupuncture Treatment Research Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Plant-based Medicinal Research
- Immune Response and Inflammation
- Endoplasmic Reticulum Stress and Disease
- Inflammasome and immune disorders
- Respiratory Support and Mechanisms
- Pain Management and Opioid Use
- Mechanical Circulatory Support Devices
- Traditional Chinese Medicine Studies
- Sirtuins and Resveratrol in Medicine
- Pharmacological Receptor Mechanisms and Effects
- NF-κB Signaling Pathways
- Ubiquitin and proteasome pathways
- Pediatric health and respiratory diseases
- Ferroptosis and cancer prognosis
- Long-Term Effects of COVID-19
- Berberine and alkaloids research
- Airway Management and Intubation Techniques
- Adipose Tissue and Metabolism
- Thermal Regulation in Medicine
- Pneumonia and Respiratory Infections
- Inflammation biomarkers and pathways
Zhongnan Hospital of Wuhan University
2010-2024
Wuhan University
2010-2024
Shandong University
2019
Shandong Provincial Hospital
2019
Alveolar epithelial barrier dysfunction in response to inflammatory reaction contributes pulmonary edema acute lung injury(ALI).Irisin,a newly-found myokine,exerts the anti-inflammatory effects. This study aims investigate protective effects of irisin on lipopolysaccharide (LPS)-induced ALIin vivo and vitro, explore its underlying mechanism. Male SD rats A549 cells were divided into 4 groups: control group, LPS Irisin pretreated Irisin/Compound C(a special inhibitor AMPK)-treated group. The...
DnaJ/Hsp40 homolog, subfamily B, member 6 (DNAJB6) is significantly down-regulated in esophageal squamous cell carcinoma (ESCC), while its complicated molecular mechanisms are still unknown. To investigate the relationship between DNAJB6 and ESCC. The expression of was detected ESCC patient by Western blot immunohistochemistry. overexpress DNAJB6a lentivirus infection, colony-forming, CCK-8, transwell, mouse xenograft assays were utilized to verify proliferous, invasive, migratory role...
Blunt chest trauma with hemorrhagic shock (THS) frequently induces pulmonary inflammation that leads to acute lung injury (ALI). Penehyclidine hydrochloride (PHC) possesses anti‑inflammatory properties may attenuate the systemic inflammatory response. The present study aimed evaluate molecular mechanism of PHC in modifying THS‑induced ALI rats. Rats underwent either THS or a sham procedure. At 6 h subsequent blunt trauma, arterial blood was drawn for gas and pro‑inflammatory factors...
Nucleotide-binding oligomerization domain 2 (NOD2) is the innate receptor of muramyl dipeptide (MDP). Our previous study revealed that MDP could enhance thermal injury-induced inflammatory cytokine production and organ function injury in rats. The present was to determine effect on autophagy NOD2/receptor-interacting serine/threonine protein kinases (RICK) signaling pathway lung after injury.Forty male Sprague-Dawlay rats were randomly divided into four groups: normal control (NC) group,...
The aim of the present study was to investigate effect penehyclidine hydrochloride (PHC) pretreatment on mice with lipopolysaccharide (LPS)‑induced acute lung injury (ALI) and its possible underlying mechanisms. Mice were randomly separated into six groups: i) Sham group; ii) LPS iii) + PHC iv) tumor necrosis factor a‑induced protein 8‑like 2 (TIPE2) v) TIPE2 vi) group. ALI model induced using through intratracheal injection. received adenovirus gene induce overexpression TIPE2. After...
Objective To investigate the effect of electro- acupuncture at zusanli on scald sepsis in rats. Methods Sixty specific pathogen free(SPF)male Sprague- Dawley rats, weighing 200-250 g, aged 2-3 months were randomly divided into six groups(n= 10 each):control group(C group), muramyl dipeptide(MDP)group, lectro- zusanli(E) group, lectric stimulation nonacupoint(NE)group, zusanli+α- bungarotoxin(α- BGT) group and only scard (S)group. Sepsis after was induced MDP, E, NE andα- BGT groups....
Cytokin storms play a key role in the pathogenesis of acute lung injury (ALI) caused by sepsis, which pulmonary macrophage PANoptosis is involved. At present, main treatment methods for sepsis-induced ALI are antibiotics and fluid resuscitation, but efficacy these unsatisfactory enough; therefore, development new therapeutic urgently needed. In this study, we developed novel bionic nanoparticle (R@ZQC NPs) using ZIF-8 nanoparticles as carrier, internally supported with ginsenoside Rb1,...
：Objective To investigatethe effect of electro-acupuncture at zusanli on Severe thermal injury-induced acute lunginjury in rats.Methods Forty male SD rats weighing 200-250 g were used thisstudy.Thirty percent the total body surface (TBS) was shaved chemically with 20% sodiumsulfate and then exposed to 99-100℃ water for 12 s.The animalswith third degree injury involving 30% TBS randomly divided into 5 groups(n=8each):group Ⅰ control(group C);groupⅡ injury;group Ⅲelectro-acupunctureat...
Objective To. investigate the effect of electroacupuncture at acupoint Zusanli (ST36) on liver injury during early stage after bum in rats. Methods Forty adult male SD rats weighing 220-250 g were randomly divided into 5 groups ( n = 8 each) : group sham operation (group Ⅰ ) ; burn Ⅱ Ⅲ ); non-acupoint stimulation Ⅳ and ST36 + alphabungarotoxin (alpha7 nicotinic acetylcholine receptor antagonist) Ⅴ ). Rats subjected to 3rd degree covering 30% total body surface area. resuscitated with...