A5052165199- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- Optical Coherence Tomography Applications
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Photoacoustic and Ultrasonic Imaging
- Coronary Interventions and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Advanced Fluorescence Microscopy Techniques
- Renal and Vascular Pathologies
- Cellular Mechanics and Interactions
- 3D Printing in Biomedical Research
- Health and Wellbeing Research
- Photonic and Optical Devices
- Physical Activity and Health
- Peripheral Artery Disease Management
- Semiconductor Lasers and Optical Devices
- Shoulder and Clavicle Injuries
- Ocular Diseases and Behçet’s Syndrome
- Cell Image Analysis Techniques
- Musculoskeletal synovial abnormalities and treatments
- Acute Kidney Injury Research
- Optical Imaging and Spectroscopy Techniques
- Microfluidic and Bio-sensing Technologies
- Cerebral Venous Sinus Thrombosis
Korea Advanced Institute of Science and Technology
2021-2023
Kyungpook National University Hospital
2022
Sangmyung University
2018-2021
Massachusetts Institute of Technology
1999-2020
IIT@MIT
2012-2019
Harvard–MIT Division of Health Sciences and Technology
2016-2017
Tufts Medical Center
2016
Carl Zeiss (United States)
2016
University of Miami
2016
Friedrich-Alexander-Universität Erlangen-Nürnberg
2016
To investigate the potential of ultrahigh-speed swept-source optical coherence tomography angiography (OCTA) to visualize retinal and choroidal vascular changes in patients with exudative age-related macular degeneration (AMD).
To investigate the utility of ultrahigh speed, swept source optical coherence tomography angiography in visualizing retinal microvascular and choriocapillaris (CC) changes diabetic patients.The study was prospective cross-sectional. A 1,050 nm wavelength, 400 kHz A-scan rate prototype used to perform volumetric CC vasculatures patients normal subjects. Sixty-three eyes from 32 subjects, 9 7 with proliferative retinopathy, 29 16 nonproliferative 51 28 without retinopathy were imaged.Retinal...
Mechanical properties of cells have been shown to a significant role in disease, as many instances cell stiffness changes when is no longer healthy. We present high-throughput microfluidics-based approach that exploits the connection between travel time through narrow passage and stiffness. The system resolves both relative diameter while retaining information on level. show stiffer transit times than less stiff ones size significantly influences times. Experiments with untreated HeLa made...
In Brief Purpose: To investigate choriocapillaris (CC) alteration in patients with nascent geographic atrophy (nGA) and/or drusen-associated (DAGA) using swept-source optical coherence tomography angiography (OCTA). Methods: A 1,050-nm wavelength, 400 kHz A-scan rate prototype was used to perform volumetric over 6 mm × fields of view nGA DAGA. The resulting (OCT) and OCTA data were analyzed a combination en face cross-sectional techniques. Variable interscan time analysis (VISTA)...
In Brief Purpose: Currently available optical coherence tomography angiography systems provide information about blood flux but only limited flow speed. The authors develop a method for mapping the previously proposed variable interscan time analysis (VISTA) algorithm into color display that encodes relative Methods: Optical was performed with 1,050 nm, 400 kHz A-scan rate, swept source system using 5 repeated B-scan protocol. Variable used to compute signal from pairs having 1.5 millisecond...
PURPOSE.To investigate the appearance of choriocapillaris (CC) flow under drusen by comparing long-wavelength (1050 nm) swept-source optical coherence tomography (SS-OCT) angiography with shorter-wavelength (840 spectral-domain (SD) OCT angiography. METHODS.Patients imaged on both devices same day were selected and graded.Ambiguous (OCTA) signal loss was defined as low OCTA en face CC image that also had in corresponding area B-scans.Unambiguous did not have B-scans.False-positive impairment...
In Brief Purpose: To develop a robust, sensitive, and fully automatic algorithm to quantify diabetes-related capillary dropout using optical coherence tomography (OCT) angiography (OCTA). Methods: A 1,050-nm wavelength, 400 kHz A-scan rate swept-source prototype was used perform volumetric imaging over 3 mm × fields in normal controls (n = 5), patients with diabetes without diabetic retinopathy (DR) 7), nonproliferative (NPDR) 9), proliferative (PDR) 5); for each patient, one eye imaged....
In this paper, we present a 1050 nm electrically-pumped micro-electro-mechanically-tunable vertical-cavity-surface-emitting-laser (MEMS-VCSEL) with record dynamic tuning bandwidth of 63.8 nm, suitable for swept source optical coherence tomography (SS-OCT) imaging. These devices provide reduced cost & complexity relative to previously demonstrated optically pumped by obviating the need pump laser and associated hardware. We demonstrate ophthalmic SS-OCT imaging MEMS-VCSEL at 400 kHz axial...
Purpose: To combine advances in high-speed, wide-field optical coherence tomography angiography (OCTA) with image processing methods for semiautomatic quantitative analysis of capillary nonperfusion patients diabetic retinopathy (DR). Methods: Sixty-eight (73 eyes), either without or different degrees retinopathy, were prospectively recruited volumetric swept-source OCTA imaging using 12 mm × fields centered at the fovea. A custom, software algorithm was used to quantify areas nonperfusion....
To examine outer retinal band changes after flash stimulus and subsequent dark adaptation with ultrahigh-resolution optical coherence tomography (UHR-OCT).Five dark-adapted left eyes of five normal subjects were imaged 3-μm axial-resolution UHR-OCT during 30 minutes following 96%, 54%, 23%, 0% full-field 54% half-field rhodopsin bleach. We identified the ellipsoid zone inner segment/outer segment (EZ[IS/OS]), cone interdigitation (CIZ), rod (RIZ), pigment epithelium (RPE), Bruch's membrane...
Polarization sensitive optical coherence tomography (PS-OCT) is a functional extension of conventional OCT and can assess depth-resolved tissue birefringence in addition to intensity.Most existing PS-OCT systems are relatively complex their clinical translation remains difficult.We present simple robust all-fiber system based on swept source technology polarization depth-encoding.Polarization multiplexing was achieved using maintaining fiber.Polarization signals were detected fiber beam...
The recent clinical adoption of optical coherence tomography (OCT) angiography (OCTA) has enabled non-invasive, volumetric visualization ocular vasculature at micron-scale resolutions. Initially limited to 3 mm × and 6 fields-of-view (FOV), commercial OCTA systems now offer 12 mm, or larger, imaging fields. While larger FOVs promise a more complete retinal disease, they also introduce new challenges the accurate reliable interpretation data. In particular, because vignetting, wide-field...
To develop an optical coherence tomography angiography (OCTA)-based framework for quantitatively analyzing the spatial distribution of choriocapillaris (CC) impairment around choroidal neovascularization (CNV) secondary to age-related macular degeneration.In a retrospective, cross-sectional study, 400-kHz swept-source OCTA images from 7 eyes 6 patients with CNV degeneration were analyzed using custom software. A lesion-centered zonal analysis technique-which portioned field-of-view into...
Purpose: To develop high-speed, extended-range, ultrahigh-resolution spectral-domain optical coherence tomography (UHR SD-OCT) and demonstrate scan protocols for clinical retinal imaging. Methods: A UHR SD-OCT operating at 840-nm with 150-nm bandwidths was developed. The axial imaging range extended by dynamically matching reference arm length to the contour during acquisition. Two were demonstrated healthy participants patients dry age-related macular degeneration. high-definition raster...
Purpose: To use a novel optical coherence tomography angiography (OCTA) algorithm termed variable interscan time analysis (VISTA) to evaluate relative blood flow speeds in polypoidal choroidal vasculopathy (PCV).Methods: Prospective cross-sectional study enrolling patients with confirmed diagnosis of PCV.OCTA the retina and choroid was obtained prototype swept-source OCT system.The acquired volumes were centered on branching vascular network (BVN) polyps as determined by indocyanine-green...
Alterations in ocular blood flow play an important role the pathogenesis and progression of diabetic retinopathy (DR). However, measurement retinal clinical studies has been challenging. En face Doppler optical coherence tomography (OCT) provides effective method for measuring total (TRBF) clinic.To investigate TRBF eyes with DR varying severity, or without macular edema (DME), using en OCT.This was a cross-sectional study conducted from May 23, 2014, to January 11, 2016, which analyzed 41...
To utilize optical coherence tomography (OCT) and OCT angiography (OCTA) to describe alterations in the retinal choriocapillaris vasculature following remote laser photocoagulation. Lesions are classified on basis of alteration as evaluated en face OCTA.This was a retrospective, cross-sectional study analyzing 28 photocoagulation scars from 8 patients treated for diabetic macular edema. All eyes were analyzed using combination OCTA, OCT, fundus photography. Two masked readers scored images...
The records of 138 patients (222 hands) who had been evaluated by preoperative nerve conduction study (NCS) and consecutive self-administered questionnaires were analyzed to determine diagnostic relations in carpal tunnel syndrome. Hands categorized into six grades (extreme, severe, moderate, mild, minimal, negative) according the three modalities: NCS data median sensory nerve, Symptom Severity Scale score, Functional Status score. authors correlation, independence, homogeneity, association...
We propose methods to align interferograms affected by trigger jitter a reference interferogram based on the information (amplitude/phase) at fixed-pattern noise location reduce residual fixedpattern and improve phase stability of swept source optical coherence tomography (SS-OCT) systems.One proposed method achieved this introducing wavenumber shift (k-shift) in interest searching for k-shift that minimized amplitude.The other calculated relative using location.Repeating alignment procedure...